The Registry of Toxic Effects of Chemical Substances

Copper (II) sulfate, pentahydrate (1:1:5)

RTECS #: GL8900000

CAS #: 7758-99-8

UPDATE: November 2003 MW: 249.70 MF: O4S•Cu•5H2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Blue copper AS
  2. Copper sulphate pentahydrate
  3. Copper (2+) sulfate pentahydrate
  4. Copper (II) sulfate pentahydrate
  5. Cupric sulfate pentahydrate
  6. Kupfersulfat - pentahydrat (German)
  1. Kupfervitriol (German)
  2. Salzburg vitriol
  3. Sulfuric acid copper (2+) salt (1:1) , pentahydrate (8CI,9CI)
  4. Sulfuric acid, copper (2+) salt, pentahydrate
  5. Vencedor


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis oral
chicken 		10 mg/kg MUREAV 367,57,1996
cytogenetic analysis intraperitoneal
chicken 		7,500 µg/kg MUREAV 367,57,1996
cytogenetic analysis intraperitoneal
mouse 		1,100 µg/kg MUREAV 243,1,1990
cytogenetic analysis rat
Ascites tumor 		300 mg/kg GANNA2 54,155,1963
DNA inhibition human lymphocyte 76 µmol/L IAAAAM 79,83,1986
unscheduled DNA synthesis rat liver 31 µmol/L CBTOE2 5,15,1989
micronucleus test intraperitoneal
chicken 		7,500 µg/kg MUREAV 367,57,1996
micronucleus test oral
chicken 		10 mg/kg MUREAV 367,57,1996
micronucleus test intraperitoneal
mouse 		5 mg/kg CYTOAN 52,801,1987
sperm morphology intraperitoneal
mouse 		5 mg/kg/5 day- intermittent CYTOAN 52,801,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mammal (species unspecified) 		lethal dose (50 percent kill): 7,500 µg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Nausea or vomiting 		JANSAG 55,337,1982
intraperitoneal
mouse 		lethal dose (50 percent kill): 33 mg/kg N/R BCPCA6 14,289,1965
intraperitoneal
rat 		lethal dose (50 percent kill): 18,700 µg/kg N/R GISAAA 53(4),78,1988
oral
wild bird 		lowest published lethal dose: 300 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Coma

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		AUVJA2 16,147,1940
oral
chicken 		lethal dose (50 percent kill): 693 mg/kg N/R VCVN1* -,67,1998
oral
duck 		lowest published lethal dose: 600 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Coma

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		AUVJA2 16,147,1940
oral
dog 		lowest published lethal dose: 60 mg/kg N/R HBAMAK 4,1289,1935
oral
dog 		lowest published toxic dose: 20 mg/kg Gastrointestinal: Nausea or vomiting JPETAB 292,1002,2000
oral
domestic animal 		lowest published lethal dose: 5 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Blood: Hemorrhage 		JCVPAR 82,47,1972
oral
human 		lowest published toxic dose: 272 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Other hemolysis with or without anemia 		IPRAA8 18,807,1965
oral
human 		lowest published lethal dose: 1,088 mg/kg Behavioral: Coma

Liver: Other changes

Blood: Other hemolysis with or without anemia 		IPRAA8 18,807,1965
oral
mammal (species unspecified) 		lowest published toxic dose: 100 mg/kg Gastrointestinal: Nausea or vomiting EJPHAZ 453,299,2002
oral
man 		lowest published toxic dose: 429 mg/kg Behavioral: Sleep

Vascular: BP lowering not characterized in autonomic section

Nutritional and Gross Metabolic: Body temperature decrease 		YAKUD5 41,193,1999
oral
mouse 		lethal dose (50 percent kill): 43 mg/kg N/R VCVN1* -,67,1998
oral
pigeon 		lowest published lethal dose: 1 gm/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Coma

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		AUVJA2 16,147,1940
oral
rat 		lethal dose (50 percent kill): 300 mg/kg N/R VCVN1* -,67,1998
subcutaneous
guinea pig 		lowest published lethal dose: 62 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Coma

Gastrointestinal: Hypermotility, diarrhea 		BMJOAE 2,217,1913
skin
rat 		lethal dose (50 percent kill): >2 gm/kg N/R NNGADV 18,S161,1993
unreported route
man 		lowest published lethal dose: 221 mg/kg N/R 85DCAI 2,73,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
mammal (species unspecified) 		lowest published toxic dose: 190 mg/kg/95 day- intermittent Behavioral: Food intake (animal)

Behavioral: Muscle weakness

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JCVPAR 108,191,1993
oral
mammal (species unspecified) 		lowest published toxic dose: 1 gm/kg/5 day- intermittent Behavioral: Food intake (animal)

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JCVPAR 108,191,1993
oral
mouse 		lowest published toxic dose: 3,390 mg/kg/2 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NIH-93-3352
oral
mouse 		lowest published toxic dose: 67 gm/kg/13 week- continuous Liver: Changes in liver weight NTPTR* NIH-93-3352
oral
rat 		lowest published toxic dose: 1,427 mg/kg/1 year- intermittent Liver: Other changes

Blood: Other changes

Nutritional and Gross Metabolic: Changes in: Fe 		KHZDAN 30(3),34,1987
oral
rat 		lowest published toxic dose: 2,625 mg/kg/2 week- continuous Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTPTR* NIH-93-3352
oral
rat 		lowest published toxic dose: 24 gm/kg/13 week- continuous Gastrointestinal: Other changes

Blood: Pigmented or nucleated red blood cells

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		NTPTR* NIH-93-3352
oral
rat 		lowest published toxic dose: 10 gm/kg/5 day/4 week- intermittent Liver: Liver function tests impaired VHTODE 42,261,2000
oral
rat 		lowest published toxic dose: 5 gm/kg/5 day/2 week- intermittent Liver: Other changes

Blood: Other changes 		VHTODE 42,261,2000
subcutaneous
turkey 		lowest published toxic dose: 100 mg/kg/14 week- intermittent Gastrointestinal: Hypermotility, diarrhea

Liver: Other changes

Blood: Other changes 		PSEBAA 128,627,1968


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,105,1998
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 mg(Cu)/m3 (fume), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.2 mg(Cu)/m3 (fume), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 mg(Cu)/m3 (dust), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg(Cu)/m3 (fume), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 1 mg(Cu)/m3 (dust), JAN1993
Occupational Exposure Limit - FINLAND time-weighted average 0.2 mg(Cu)/m3 (fume), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 1 mg(Cu)/m3 (dust), JAN1999
Occupational Exposure Limit - FRANCE VME 0.2 mg(Cu)/m3 (fume), JAN1993
Occupational Exposure Limit - FRANCE VME 1 mg(Cu)/m3, short term exposure limit 2 mg(Cu)/m3 (dust), JAN1993
Occupational Exposure Limit - GERMANY MAK 0.1 mg(Cu)/m3 (fume), JAN1999
Occupational Exposure Limit - GERMANY MAK 1 mg(Cu)/m3 (dust), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 0.2 mg(Cu)/m3, short term exposure limit 0.4 mg(Cu)/m3 (dust), JAN1993
Occupational Exposure Limit - INDIA time-weighted average 0.2 mg(Cu)/m3 (fume), JAN1993
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1.0 mg(Cu)/m3 (fume), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.1 mg(Cu)/m3 (fume), JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 ppm (1 mg(Cu)/m3) (dust), JAN1993
Occupational Exposure Limit - SWEDEN NGV 0.2 mg(Cu)/m3 (resp. dust), JAN1999
Occupational Exposure Limit - SWEDEN NGV 1 mg(Cu)/m3 (total dust), JAN1999
Occupational Exposure Limit - SWITZERLAND time-weighted average 0.1 mg(Cu)/m3, short term exposure limit 0.2 mg(Cu)/m3 (fume), JAN1999
Occupational Exposure Limit - SWITZERLAND time-weighted average 1 mg(Cu)/m3, short term exposure limit 1 mg(Cu)/m3, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.1 mg(Cu)/m3 (fume), JAN1993
Occupational Exposure Limit - THAILAND time-weighted average 1 mg(Cu)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM LTEL 0.2 mg(Cu)/m3 (fume), JAN1993
Occupational Exposure Limit - UNITED KINGDOM LTEL 1 mg(Cu)/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5421;
Number of Industries 13;
Total Number of Facilities 979;
Number of Occupations 21;
Total Number of Employees Exposed 10,821;
Total Number of Female Employees Exposed 3,606


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
NTP Toxicity studies, RPT# TOX-29, October 2000


REFERENCES:

CODEN
REFERENCE
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
AUVJA2 Australian Veterinary Journal. (Australian Veterinary Assoc., Executive Director, 134-136 Hampden Road, Artarmon, N.S.W., Australia) V.2- 1927-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301 N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984-
CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1929-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
IAAAAM International Archives of Allergy and Applied Immunology. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1950-
IPRAA8 Indian Practitioner. (Sassoon Bldg., III Floor, 143 M. G. Rd., Bombay 400 023, India) V.1- 1947/48-
JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309 W. Clark St., Champaign, IL 61820) V.1- 1942-
JCVPAR Journal of Comparative Pathology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.75- 1965-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.9- 1966-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

Used as intermediate and wood preservative, also used in production of copper compounds

NIOSH PROFILE (COPPER and COMPOUNDS), SRC, 3/82

FDA-over the counter drug

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Human Data

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