The Registry of Toxic Effects of Chemical Substances
Cobalt, di - mu - carbonylhexacarbonyldi - , (Co - Co) |
UPDATE: November 2004 | MW: 341.94 | MF: C8Co2O8 |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
N/R | N/R | N/R | N/R |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation mouse | lethal concentration (50 percent kill): 26,900 痢/m3/2 hour |
Olfaction: Other olfaction effects Eye: Other eye effects Lung, Thorax, or Respiration: Dyspnea | VRDEA5 (2),101,1969 |
inhalation rat | lethal concentration (50 percent kill): 165 mg/m3 | Lung, Thorax, or Respiration: Acute pulmonary edema | VRDEA5 (2),101,1969 |
oral mouse | lethal dose (50 percent kill): 378 mg/kg | N/R | GISAAA 38(1),97,1973 |
oral rat | lethal dose (50 percent kill): 754 mg/kg | N/R | GISAAA 38(1),97,1973 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
oral rat | lowest published toxic dose: 3,468 mg/kg/23 day- intermittent |
Cardiac: Cardiomyopathy including infarction Endocrine: Hyperglycemia Blood: Pigmented or nucleated red blood cells | GISAAA 38(1),97,1973 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | time-weighted average 0.1 mg(Co)/m3 | DTLVS* TLV/BEI,2003 |
International Agency for Research on Cancer (IARC) Cancer Review | Human Inadequate Evidence | IMEMDT 52,363,1991 |
International Agency for Research on Cancer (IARC) Cancer Review | Group 2B | IMEMDT 52,363,1991 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Occupational Exposure Limit - AUSTRALIA | time-weighted average 0.01 mg/m3, JAN1993 | |
Occupational Exposure Limit - BELGIUM | time-weighted average 0.1 mg/m3, JAN1993 | |
Occupational Exposure Limit - DENMARK | time-weighted average 0.1 mg(Co)/m3, JAN1999 | |
Occupational Exposure Limit - FRANCE | VME 0.1 mg/m3, JAN1999 | |
Occupational Exposure Limit - HUNGARY | time-weighted average 0.01 mg/m3, short term exposure limit 0.02 mg/m3, JAN1993 | |
Occupational Exposure Limit - JAPAN | Occupational Exposure Limit 0.05 mg(Co)/m3, 2B Carcinogen, JAN1999 | |
Occupational Exposure Limit - UNITED KINGDOM | time-weighted average 0.1 mg(Co)/m3, SEP2000 | |
Occupational Exposure Limit - THE NETHERLANDS | MAC-TGG 0.1 mg/m3, 2003 | |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; time-weighted average 0.1 mg(Co)/m3 | |
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg(Co)/m3 |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO COBALT CARBONYL-air | 10 hour time-weighted average 0.1 mg/m3 | NIOSH* DHHS #95-121,1995 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
OSHA ANALYTICAL METHOD #ID-125G |
REFERENCES: | |
CODEN |
REFERENCE |
DTLVS* | The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 |
GISAAA | Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- |
IMEMDT | IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- |
NIOSH* | National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. |
VRDEA5 | Vrachebnoe Delo. Medical Practice. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1918- |