The Registry of Toxic Effects of Chemical Substances

Cobalt (II) sulfate (1:1)

RTECS #: GG3100000

CAS #: 10124-43-3

UPDATE: May 2005 MW: 154.99 MF: O4S•Co


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Cobalt monosulfate
  2. Cobalt (II) sulfate
  3. Cobaltous sulfate
  4. Cobalt sulfate
  1. Cobalt sulfate (1:1)
  2. Cobalt (II) sulphate
  3. Sulfuric acid, cobalt (2+) salt (1:1)
  4. Cobalt (2+) sulfate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 126 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		INJPD2 23,153,1991
intraperitoneal
rat 		lethal dose (50 percent kill): 31,600 µg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		INJPD2 23,153,1991
intravenous
dog 		lowest published lethal dose: 20 mg/kg N/R HBAMAK 4,1289,1935
intravenous
mouse 		lethal dose (50 percent kill): 27,100 µg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		INJPD2 23,153,1991
intravenous
rat 		lethal dose (50 percent kill): 18,200 µg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		INJPD2 23,153,1991
oral
mouse 		lethal dose (50 percent kill): 584 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		INJPD2 23,153,1991
oral
rat 		lethal dose (50 percent kill): 424 mg/kg Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FCTOD7 20,311,1982
oral
rat 		lethal dose (50 percent kill): 424 mg/kg Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Hemorrhage 		VCVN5* -,453,1989
oral
rabbit 		lowest published lethal dose: 1,800 mg/kg N/R HBAMAK 4,1289,1935
unreported route
rabbit 		lowest published toxic dose: 0.2 mg/kg Vascular: BP lowering not characterized in autonomic section VCVN5* -,456,1989


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 140 mg/kg/2 week- intermittent Cardiac: Other changes VCVN5* -,459,1989
oral
rabbit 		lowest published toxic dose: 140 mg/kg/2 week- intermittent Cardiac: Other changes VCVN5* -,459,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 52,363,1991
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 52,363,1991


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1023;
Number of Industries 12;
Total Number of Facilities 387;
Number of Occupations 22;
Total Number of Employees Exposed 8,273
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1023;
Number of Industries 67;
Total Number of Facilities 5,293;
Number of Occupations 41;
Total Number of Employees Exposed 44,607;
Total Number of Female Employees Exposed 11,292


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in pigments, glazes, plating, additive to soils and animal feed, water purification
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used in pigments, glazes, plating, additive to soils and animal feed, water purification

NIOSH PROFILE (COBALT and ITS COMPOUNDS), SRI, 10/77

RTECS Compound Description:
   Tumorigen
   Mutagen

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