The Registry of Toxic Effects of Chemical Substances

Cobalt (2+) oxide

RTECS #: GG2800000

CAS #: 1307-96-6

UPDATE: November 2003 MW: 74.93 MF: CoO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. C.I. 77322
  2. C.I. Pigment Black 13
  3. Cobalt Black
  4. Cobalt monooxide
  1. Cobalt monoxide
  2. Cobaltous oxide
  3. Monocobalt oxide
  4. Zaffre


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rat 		lowest published toxic dose: 135 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		CNREA8 22,152,1962
intramuscular
rat 		toxic dose : 90 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Musculoskeletal: Tumors

Tumorigenic: Tumors at site of application 		CNREA8 22,158,1962


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
mouse 		lowest published lethal dose: 400 mg/kg N/R CNREA8 22,152,1962
intratracheal
rat 		lowest published lethal dose: 50 mg/kg N/R VCVN5* -,452,1989
intratracheal
rat 		lowest published toxic dose: 25 mg/kg Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Fibrosing alveolitis 		VCVN5* -,452,1989
oral
dog 		lowest published lethal dose: 89 mg/kg N/R EQSSDX 1,1,1975
oral
rat 		lethal dose (50 percent kill): 202 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FCTOD7 20,311,1982
oral
rat 		lethal dose (50 percent kill): 202 mg/kg Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Hemorrhage 		VCVN5* -,453,1989
subcutaneous
mouse 		lethal dose (50 percent kill): 125 mg/kg N/R ZVKOA6 19,186,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic dose: 50 mg/m3/8 hour/35 day- intermittent Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0555434
inhalation
rat 		lowest published toxic concentration: 50 mg/m3/8 hour/19 day- intermittent Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0555434
inhalation
rabbit 		lowest published toxic concentration: 50 mg/m3/8 hour/35 day- intermittent Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0555434
oral
rat 		lowest published toxic dose: 783 mg/kg/90 day- continuous Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0555434
subcutaneous
mouse 		lowest published toxic dose: 125 mg/kg/5 day- intermittent Behavioral: Tetany

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVN5* -,458,1989
subcutaneous
rat 		lowest published toxic dose: 1,144 mg/kg/9 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Endocrine: Changes in adrenal weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		GISAAA 26(10),27,1961
subcutaneous
rat 		lowest published toxic dose: 100 mg/kg/5 day- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal) 		VCVN5* -,458,1989
subcutaneous
rat 		lowest published toxic dose: 300 mg/kg/15 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVN5* -,458,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 52,363,1991
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 52,363,1991
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 52,363,1991
TOXICOLOGY REVIEW
FCTXAV 9,105,1971


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: A1683;
Number of Industries 4;
Total Number of Facilities 77;
Number of Occupations 12;
Total Number of Employees Exposed 3,559;
Total Number of Female Employees Exposed 1,767


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in electronics and ceramics
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
ZVKOA6 Zhurnal Vsesoyuznogo Khimicheskogo Obshchestva im. D.I. Mendeleeva. Journal of the D.I. Mendeleeva All-Union Chemical Society. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.5- 1960-

Used in electronics and ceramics

NIOSH PROFILE (COBALT and ITS COMPOUNDS), SRI, 10/77

RTECS Compound Description:
   Tumorigen

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