The Registry of Toxic Effects of Chemical Substances

Coal - tar pitch

RTECS #: GF8655000

CAS #: 65996-93-2

UPDATE: May 2005 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Coal tar pitch volatiles (ACGIH:OSHA)
  2. Pitch
  1. Pitch, coal tar


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intratracheal
rat 		lowest published toxic dose: 1 gm/kg/10 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		CRNGDP 13,233,1992
skin
mouse 		lowest published toxic dose: 36 gm/kg/18 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		AJIMD8 2,59,1981
skin
mouse 		toxic dose : 4,200 mg/kg/31 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		TXAPA9 18,41,1971
skin
mouse 		toxic dose : 82 gm/kg/52 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors 		HYSAAV 33(4-6),180,1968


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 880 mg/m3/7 day- continuous Eye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVPS* -,146,1998
inhalation
mouse 		lowest published toxic concentration: 50 mg/m3/4 week- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVPS* -,146,1998
inhalation
rat 		lowest published toxic concentration: 10 mg/m3/4 hour/8 week- intermittent Blood: Changes in erythrocyte (RBC) count

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation 		VCVPS* -,131,1998
inhalation
rat 		lowest published toxic concentration: 10 mg/m3/4 hour/17 week- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Blood: Normocytic anemia

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion) 		VCVPS* -,131,1998


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 35,83,1985
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 35,83,1985
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 3,22,1973
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMSUDL 7,174,1987
TOXICOLOGY REVIEW
JIDHAN 5,462,1924
TOXICOLOGY REVIEW
PAASAH 54,171,1959


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.2 mg/m3 DTLVS* 3,57,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.2 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.2 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.2 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.2 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - DENMARK time-weighted average 0.2 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.2 mg/m3, JAN1999
Occupational Exposure Limit - UNITED KINGDOM LTEL 0.14 mg/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO COAL TAR PRODUCTS-air 10 hour time-weighted average 0.1 mg/m3 CHE fraction MMWR** 37(S-7),9,1988
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T0535;
Number of Industries 4;
Total Number of Facilities 190;
Number of Occupations 6;
Total Number of Employees Exposed 1,354
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T0535;
Number of Industries 20;
Total Number of Facilities 1,235;
Number of Occupations 22;
Total Number of Employees Exposed 19,021;
Total Number of Female Employees Exposed 98


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
OSHA ANALYTICAL METHOD #ID-58


REFERENCES:

CODEN
REFERENCE
AJIMD8 American Journal of Industrial Medicine. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For publisher information, see AEHLAU.
MMWR** MMWR. Morbidity and Mortality Weekly Report. (Centers for Disease Control, Atlanta, GA 30333) V.25(10)- 1976- for RTECS citation, only V.34(Suppl 1S), 1985 is used.
PAASAH Publication of the American Association for the Advancement of Science. (Washington, DC) No.1-94, 1934-73. Discontinued.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVPS* "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.

NIOSH PROFILE (ALUMINUM REDUCTION PLANTS), FIRL, 4/78

RTECS Compound Description:
   Tumorigen
   Human Data

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