The Registry of Toxic Effects of Chemical Substances
Clay (kaolin) |
UPDATE: November 2004 | MW: N/R | MF: N/R |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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N/R
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N/R
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N/R
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N/R
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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oral | rat
lowest published toxic dose: 590 gm/kg (37 day prior to copulation/1-22 day pregnant)
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Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
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JONUAI 107,2020,1977
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oral | rat
lowest published toxic dose: 370 gm/kg (37 day prior to copulation/1-22 day pregnant)
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Reproductive: Other effects on female | Reproductive: Effects on newborn: Other neonatal measures or effects
JONUAI 107,2020,1977
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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intracerebral | rat
lowest published toxic dose: 125 mg/kg/2 minute
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Brain and Coverings: Changes in cerebral spinal fluid | Brain and Coverings: Other degenerative changes Immunological Including Allergic: Increase in cellular immune response
IJNUB7 92,9,1997
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intrapleural | guinea pig
lowest published toxic dose: 150 mg/kg
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Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)
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INHEAO 19,85,1981
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intratracheal | guinea pig
lowest published toxic dose: 150 mg/kg/2 minute
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Lung, Thorax, or Respiration: Fibrosis (interstitial)
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INDHE* 19,85,1981
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | hamster
lowest published toxic concentration: 30 mg/m3/72 week- intermittent
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Lung, Thorax, or Respiration: Fibrosis (interstitial) | Lung, Thorax, or Respiration: Other changes Gastrointestinal: Tumors
8COLD* 1,480,1993
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inhalation | hamster
lowest published toxic concentration: 30 mg/m3/72 week- intermittent
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Lung, Thorax, or Respiration: Fibrosis (interstitial) | Lung, Thorax, or Respiration: Tumors
EPASR* 89-900000360
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inhalation | hamster
lowest published toxic concentration: 30 mg/m3/24 week- intermittent
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Lung, Thorax, or Respiration: Other changes | Lung, Thorax, or Respiration: Fibrosis (interstitial)
EVHPAZ 102,207,1994
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inhalation | hamster
lowest published toxic concentration: 30 mg/m3/48 week- intermittent
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Lung, Thorax, or Respiration: Fibrosis (interstitial) | Lung, Thorax, or Respiration: Tumors
INHTE5 7,503,1995
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inhalation | rat
lowest published toxic concentration: 300 mg/m3/12 week- intermittent
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Lung, Thorax, or Respiration: Other changes
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17IPC* -,897,1990
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inhalation | rat
lowest published toxic concentration: 30 mg/m3/96 week- intermittent
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Lung, Thorax, or Respiration: Fibrosis (interstitial) | Lung, Thorax, or Respiration: Other changes Lung, Thorax, or Respiration: Tumors
8COLD* 1,480,1993
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inhalation | rat
lowest published toxic concentration: 9 mg/m3/96 week- intermittent
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Lung, Thorax, or Respiration: Fibrosis (interstitial)
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8COLD* 1,480,1993
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inhalation | rat
lowest published toxic concentration: 30 mg/m3/72 week- intermittent
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Lung, Thorax, or Respiration: Tumors
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EPASR* 89-900000360
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inhalation | rat
lowest published toxic concentration: 30 mg/m3/48 week- intermittent
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Lung, Thorax, or Respiration: Fibrosis (interstitial)
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EPASR* 89-900000360
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inhalation | rat
lowest published toxic concentration: 30 mg/m3/96 week- intermittent
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Lung, Thorax, or Respiration: Other changes | Lung, Thorax, or Respiration: Tumors
EVHPAZ 102,207,1994
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oral | rat
lowest published toxic dose: 370 gm/kg/37 day- intermittent
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Blood: Normocytic anemia | Blood: Other changes Blood: Changes in erythrocyte (RBC) count
JONUAI 107,2020,1977
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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time-weighted average 2 mg/m3 (E,R)
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DTLVS* TLV/BEI,2003
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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Not Classifiable as a Human Carcinogen
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DTLVS* TLV/BEI,2003
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD
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NUISANCE PARTICULATES
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DTLWS* 3,21,1973
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)
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8 hour time-weighted average 15 mg/m3, total dust
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CFRGBR 29,1910.1000,1994
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)
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8 hour time-weighted average 5 mg/m3, respirable fraction
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CFRGBR 29,1910.1000,1994
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)
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8 hour time-weighted average 15 mg/m3, total dust
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CFRGBR 29,1926.55,1994
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)
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8 hour time-weighted average 5 mg/m3, respirable fraction
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CFRGBR 29,1926.55,1994
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)
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8 hour time-weighted average 15 mg/m3, total dust
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CFRGBR 29,1915.1000,1993
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)
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8 hour time-weighted average 5 mg/m3, respirable fraction
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CFRGBR 29,1915.1000,1993
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Occupational Exposure Limit - AUSTRALIA
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time-weighted average 10 mg/m3, JAN1993
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Occupational Exposure Limit - BELGIUM
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time-weighted average 10 mg/m3, JAN1993
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Occupational Exposure Limit - FRANCE
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VME 10 mg/m3, JAN1999
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Occupational Exposure Limit - SWITZERLAND
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MAK- week 6 mg/m3, JAN1999
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Occupational Exposure Limit - UNITED KINGDOM
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time-weighted average 3 mg/m3, respirable dust, SEP2000
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Occupational Exposure Limit - UNITED KINGDOM
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time-weighted average 2 mg/m3, Respirable dust, SEP2000
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Occupational Exposure Limit - THE NETHERLANDS
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MAC-TGG 10 mg/m3, 2003
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Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; | Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value |
Not Classifiable as a Human Carcinogen |
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO KAOLIN, respirable fraction-air
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10 hour time-weighted average 5 mg/m3
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NIOSH* DHHS #92-100,1992
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National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO KAOLIN, total dust-air
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10 hour time-weighted average 10 mg/m3
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NIOSH* DHHS #92-100,1992
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National Occupational Hazard Survey 1974
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National Occupational Hazard Survey 1974: Hazard Code: 41775; | Number of Industries 111; Total Number of Facilities 14,181; Number of Occupations 88; Total Number of Employees Exposed 155,396
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: X1959; | Number of Industries 1; Total Number of Facilities 3; Number of Occupations 1; Total Number of Employees Exposed 17
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: X6880; | Number of Industries 23; Total Number of Facilities 1,734; Number of Occupations 24; Total Number of Employees Exposed 25,166; Total Number of Female Employees Exposed 3,162
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: X9449; | Number of Industries 1; Total Number of Facilities 7; Number of Occupations 2; Total Number of Employees Exposed 1,354
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: X9507; | Number of Industries 1; Total Number of Facilities 62; Number of Occupations 1; Total Number of Employees Exposed 125
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: 41775; |
Number of Industries 240; Total Number of Facilities 43,700; Number of Occupations 156; Total Number of Employees Exposed 745,593; Total Number of Female Employees Exposed 114,032 |
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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Used as thickeners, opacifiers, extenders in polymer systems
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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REFERENCES:
CODEN
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REFERENCE
17IPC*
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Proceedings of the VIIth International Pneumoconioses Conference, Pittsburgh, Pennsylvania,
August 23-26, 1988. NIOSH, U.S. Department of Health and Human Services, DHHS (NIOSH).
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8COLD*
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Proceedings, Eighth International Conference on Occupational Lung Diseases, Prague,
Czechoslovakia, September 14-17, 1993
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CFRGBR
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Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents,
Washington, DC 20402)
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DTLVS*
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The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
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DTLWS*
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"Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For
publisher information, see 85INA8.
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EPASR*
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United States Environmental Protection Agency, Office of Pesticides and Toxic Substances.
(U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
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EVHPAZ
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EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents,
Washington, DC 20402) No.1- 1972-
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IJNUB7
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International Journal of Neuroscience. (Gordon & Breach Science Pub. S.A., 50 W. 23rd St.,
New York, NY 10010) V.1- 1970-
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INDHE*
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Industrial Health (journal) V.19- 1981-
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INHEAO
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Industrial Health. (National Institute of Industrial Health, 6-21-1 Nagao, Tama-ku, Kawasaki,
213 Japan) V.1- 1963-
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INHTE5
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Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P
4EE) V.1- 1989-
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JONUAI
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Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1-
1928-
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NIOSH*
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National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and
Welfare, Reports and Memoranda.
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