The Registry of Toxic Effects of Chemical Substances

Citric acid, triethyl ester

RTECS #: GE8050000

CAS #: 77-93-0

UPDATE: January 1997 MW: 276.32 MF: C12H20O7


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Citroflex 2
  2. Triaethylcitrat (German)
  3. Ethyl citrate
  4. NSC 8907
  1. 1,2,3 - Propanetricarboxylic acid, 2 - hydroxy - , triethyl ester (9CI)
  2. TEC
  3. Triethyl citrate
  4. Triethylester kyseliny citronove (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 1,300 ppm/6 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Pleural effusion

Lung, Thorax, or Respiration: Dyspnea 		14CYAT 2,1892,1963
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,750 mg/kg Behavioral: Somnolence (general depressed activity)

Vascular: Other changes 		JPMSAE 53,774,1964
intraperitoneal
rat 		lethal dose (50 percent kill): 4 gm/kg Behavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease 		IYKEDH 16,214,1985
oral
cat 		lethal dose (50 percent kill): 3,500 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Gastrointestinal: Nausea or vomiting 		FCTXAV 17,389,1979
oral
guinea pig 		lethal dose (50 percent kill): >25 mL/kg N/R GWXXBX #2703360
oral
rat 		lethal dose (50 percent kill): 5,900 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease 		IYKEDH 16,214,1985
subcutaneous
rat 		lethal dose (50 percent kill): 6,600 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease 		IYKEDH 16,214,1985
skin
rabbit 		lethal dose (50 percent kill): >5 gm/kg N/R FCTXAV 17,389,1979


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 4,900 mg/kg/14 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JPMSAE 53,774,1964
oral
cat 		lowest published toxic dose: 15,904 mg/kg/8 week- continuous Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Behavioral: Ataxia 		TXAPA9 1,283,1959


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7556;
Number of Industries 9;
Total Number of Facilities 358;
Number of Occupations 20;
Total Number of Employees Exposed 11,496;
Total Number of Female Employees Exposed 3,993


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New York, John Wiley & Sons, Inc., 1958-63
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231)
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
   Drug

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