The Registry of Toxic Effects of Chemical Substances

Chromium hydroxide sulfate

RTECS #: GB6240000

CAS #: 12336-95-7

UPDATE: September 2000 MW: 165.07 MF: CrHO5S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Basic chromic sulfate
  2. Basic chromium sulfate
  3. Cromo solfato basificato (Spanish)
  1. Monobasic chromium sulfate
  2. Peachrome
  3. Chromedol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		50 mg severe TOVEFN (2)34,1998


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 5 mg/L BJCAAI 44,219,1981
cytogenetic analysis human other cell types 500 mg/L BJCAAI 44,219,1981
DNA inhibition hamster kidney 500 mg/L BJCAAI 44,219,1981
other mutation test systems hamster kidney 500 mg/L BJCAAI 44,219,1981
other mutation test systems human other cell types 500 mg/L BJCAAI 44,219,1981
sister chromatid exchange hamster ovary 10 mg/L CRNGDP 6,1327,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lethal dose (50 percent kill): 2,900 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Behavioral: Irritability 		TOVEFN (2),34,1998
oral
rat 		lethal dose (50 percent kill): 7,760 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Behavioral: Irritability 		TOVEFN (2),34,1998
oral
woman 		lowest published lethal dose: 960 mg/kg Cardiac: Other changes

Gastrointestinal: Changes in structure or function of exocrine pancreas

Gastrointestinal: Necrotic changes 		ICMED9 20,145,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 58 mg/m3/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight 		NTIS** OTS0557882
inhalation
rat 		lowest published toxic concentration: 17 mg/m3/6 hour/5 day- intermittent Lung, Thorax, or Respiration: Other changes TOSCF2 52,278,1999
oral
rat 		lowest published toxic dose: 23,280 mg/kg/30 day- intermittent Brain and Coverings: Recordings from specific areas of CNS

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOVEFN (2),34,1998


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 49,49,1990
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 49,49,1990
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 49,49,1990


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: E0022;
Number of Industries 2;
Total Number of Facilities 51;
Number of Occupations 4;
Total Number of Employees Exposed 1,155;
Total Number of Female Employees Exposed 51


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the tanning industry
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
ICMED9 Intensive Care Medicine. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1977-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown

Used in the tanning industry

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

ALT CAS #: 39380-78-4
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