The Registry of Toxic Effects of Chemical Substances

Chromium (III) chloride, hexahydrate (1:3:6)

RTECS #: GB5450000

CAS #: 10060-12-5

UPDATE: August 2004 MW: 266.47 MF: Cl3Cr•6H2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Chromium chloride, hexahydrate (8CI,9CI)
  2. Chlorid chromity hexahydrat (Czech)
  3. Chromic chloride hexahydrate
  4. Hexaaquachromium chloride
  1. Hexaaquachromium (III) chloride
  2. Chromium sesquichloride
  3. Chromium trichloride hexahydrate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human lymphocyte 2,500 µg/L MUREAV 191,207,1987
cytogenetic analysis human leukocyte 400 mg/L SAIGBL 18,136,1976
DNA adduct hamster kidney 500 mg/L CBINA8 37,309,1981
DNA adduct intraperitoneal
rat 		80 mg/kg CNREA8 45,1146,1985
DNA damage cattle other cell types 0.1 mmol/L/1 hour EVHPAZ 108,399,2000
DNA damage hamster lung 10 µmol/L MUREAV 117,279,1983
DNA repair Escherichia coli 31 µg/well MUREAV 133,161,1984
other mutation test systems hamster kidney 500 mg/L CBINA8 37,309,1981
other mutation test systems human other cell types 500 mg/L BJCAAI 44,219,1981
sister chromatid exchange hamster lung 39 mg/L CRNGDP 4,605,1983
sister chromatid exchange hamster fibroblast 32 mg/L MUREAV 104,141,1982


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 134 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Specific developmental abnormalities: Central nervous system 		TXCYAC 26,257,1983
intraperitoneal
mouse 		lowest published toxic dose: 266 mg/kg (1 day male) Reproductive: Other reproductive system tumors TXAPA9 158,161,1999
intraperitoneal
mouse 		lowest published toxic dose: 266.5 mg/kg (1 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)

Reproductive: Effects on newborn: Biochemical and metabolic 		EVHPAZ 110,801,2002
intraperitoneal
mouse 		lowest published toxic dose: 26.6 mg/kg (1 day male) Reproductive: Effects on newborn: Biochemical and metabolic EVHPAZ 110,801,2002


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 285 mg/kg N/R TXAPA9 63,461,1982
intraperitoneal
mouse 		lowest published toxic dose: 266.47 mg/kg Endocrine: Hyperglycemia

Endocrine: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		EVHPAZ 110,801,2002
intravenous
frog 		lowest published lethal dose: 374 mg/kg N/R AIPTAK 62,330,1939
intravenous
mouse 		lowest published lethal dose: 1,602 mg/kg N/R AIPTAK 62,330,1939
intravenous
rabbit 		lowest published lethal dose: 576 mg/kg N/R AIPTAK 62,330,1939
oral
rat 		lethal dose (50 percent kill): 1,790 mg/kg N/R MarJV# 29MAR1977
oral
rat 		lowest published toxic dose: 895 mg/kg Biochemical: Metabolism (intermediary): Lipids including transport TXCYAC 180,5,2002


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 mg(Cr)/m3 DTLVS* TLV/BEI,1999
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as a human carcinogen DTLVS* TLV/BEI,1999
TOXICOLOGY REVIEW
85DHAX Cr,22,1974


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 mg(Cr)/m3 DTLVS* 3,35,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 mg(Cr)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 mg(Cr)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 mg(Cr)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 mg(Cr)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRIA Suspected Carcinogen, JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 0.5 mg(Cr)/m3, JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.5 mg(Cr)/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.5 mg(Cr)/m3, JAN1999
Occupational Exposure Limit - POLAND time-weighted average 0.5 mg(Cr)/m3, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 0.5 mg(Cr)/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 mg(Cr)/m3, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 mg(Cr)/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as a human carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as a human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9134;
Number of Industries 1;
Total Number of Facilities 41;
Number of Occupations 2;
Total Number of Employees Exposed 573;
Total Number of Female Employees Exposed 203


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-mammalian oocyte


REFERENCES:

CODEN
REFERENCE
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MarJV# Personal Communication from J.V. Marhold, VUOS, 539-18, Pardubice, Czechoslavakia, Mar. 29, 1977
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

RTECS Compound Description:
   Mutagen
   Reproductive Effector

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