The Registry of Toxic Effects of Chemical Substances

Chromic acid, zinc salt

RTECS #: GB3290000

CAS #: 13530-65-9

UPDATE: November 2004 MW: 181.37 MF: CrO4•Zn


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Buttercup Yellow
  2. C.I. 77955
  3. Chromium zinc oxide (ZrCrO4)
  4. ZTO
  5. Zinc Chrome Yellow
  6. Zinc chromate (ACGIH:OSHA)
  7. Zinc chromate AM
  8. Zinc chromate C
  9. Zinc chromate O
  10. Zinc chromate T
  11. Zinc chromate Z
  1. Zinc chromate (VI) hydroxide
  2. Zinc chromates
  3. Zinc chromates (ACGIH)
  4. Zinc chrome
  5. Zinc chrome (anti - corrosion)
  6. Zinc chromium oxide (ZrCrO4)
  7. Zinc hydroxychromate
  8. Zinc tetraoxychromate
  9. Zinc tetraoxychromate 76A
  10. Zinc tetraoxychromate 780B
  11. Zincro ZTO


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 5 mg/L BJCAAI 44,219,1981
cytogenetic analysis human other cell types 500 mg/L BJCAAI 44,219,1981
DNA inhibition hamster kidney 50 mg/L BJCAAI 44,219,1981
mutation in microorganisms Salmonella typhimurium 800 ng/plate (+enzymatic activation step) MUREAV 156,219,1985
mutation in mammalian somatic cells hamster lung 4 mg/L MUREAV 67,55,1979
morphological transform hamster kidney 14 mg/L TECSDY 12,185,1986
morphological transform hamster embryo 10 µmol/L CNREA8 39,193,1979
other mutation test systems hamster kidney 50 mg/L BJCAAI 44,219,1981
other mutation test systems human other cell types 500 mg/L BJCAAI 44,219,1981
sister chromatid exchange hamster ovary 100 µg/L MUREAV 156,219,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
man 		lowest published toxic concentration: 5 mg/m3/8 hour/7 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma 		BJIMAG 32,62,1975
implant
rat 		lowest published toxic dose: 12,928 µg/kg Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma 		BJIMAG 43,243,1986
subcutaneous
rat 		lowest published toxic dose: 135 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		PBPHAW 14,47,1978


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
mouse 		lowest published lethal dose: 30 mg/kg N/R AQMOAC #70-15,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.01 mg(Cr)/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 23,205,1980
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 49,49,1990
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 23,205,1980
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 49,49,1990
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMEMDT 49,49,1990
TOXICOLOGY REVIEW
85DHAX Cr,22,1974


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 0.1 mg(CrO3)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg(CrO3)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 0.1 mg(CrO3)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 0.1 mg(CrO3)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.01 mg/m3, Carcinogen, JAN1993
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.01 mg/m3, Carcinogen, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.02 mg(Cr)/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.05 mg(Cr)/m3, JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.05 mg(Cr)/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.02 mg(CrO3)/m3, JAN1999
Occupational Exposure Limit - POLAND time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 0.02 mg(Cr)/m3, Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.01 mg(Cr)/m3, Carcinogen, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 mg(Cr)/m3, Carcinogen, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ZINC CHROMATE-air Carcinogen;
10 hour time-weighted average 0.001 mg/m3 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0900;
Number of Industries 108;
Total Number of Facilities 9,236;
Number of Occupations 57;
Total Number of Employees Exposed 79,219
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0900;
Number of Industries 71;
Total Number of Facilities 5,081;
Number of Occupations 57;
Total Number of Employees Exposed 58,924;
Total Number of Female Employees Exposed 4,190


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an anti-corrosion pigment in primers and as a coloring agent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 4, 1975/1976
NTP 10th Report on Carcinogens,2002:Known to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued.
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PBPHAW Progress in Biochemical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1965-
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-

Used as an anti-corrosion pigment in primers and as a coloring agent

NIOSH PROFILE (ZINC AND ITS COMPOUNDS), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

ALT CAS #: 1308-13-0
ALT CAS #: 1328-67-2
ALT CAS #: 14675-41-3
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