The Registry of Toxic Effects of Chemical Substances

Chromic acid, lead (2+) salt (1:1)

RTECS #: GB2975000

CAS #: 7758-97-6

UPDATE: May 2005 MW: 323.19 MF: CrO4•Pb


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Chromate de plomb (French)
  2. Lead chromate
  3. Lead chromate (VI)
  1. Lead chromate (ACGIH)
  2. Lead chromium oxide
  3. Plumbous chromate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 5 mg/L BJCAAI 44,219,1981
cytogenetic analysis human lymphocyte 13 µmol/L MUREAV 77,157,1980
cytogenetic analysis human other cell types 500 mg/L BJCAAI 44,219,1981
DNA damage hamster ovary 1 µmol/L MUREAV 280,129,1992
DNA damage hamster ovary 350 µmol/L/24 hour TXAPA9 146,270,1997
DNA inhibition hamster kidney 150 mg/L BJCAAI 44,219,1981
mutation in microorganisms Escherichia coli 2 µmol/L (-enzymatic activation step) MUREAV 91,33,1981
mutation in microorganisms Salmonella typhimurium 200 µg/plate (+/-enzymatic activation step) MUREAV 66,357,1979
micronucleus test intraperitoneal
mouse 		500 mg/kg TJEMAO 146,373,1985
gene conversion and mitotic recombination Saccharomyes cerevisiae 62,500 µg/L MUREAV 66,357,1979
mutation in mammalian somatic cells hamster ovary 8 µmol/L CRNGDP 13,2053,1992
morphological transform hamster kidney 156 mg/L TECSDY 12,185,1986
morphological transform hamster embryo 40 µmol/L CNREA8 39,193,1979
morphological transform human fibroblast 500 nmol/L CNREA8 47,3815,1987
morphological transform mouse fibroblast 25 µmol/L CNREA8 48,5280,1988
other mutation test systems hamster kidney 150 mg/L BJCAAI 44,219,1981
other mutation test systems human other cell types 500 mg/L BJCAAI 44,219,1981
sister chromatid exchange hamster ovary 100 µg/L MUREAV 156,219,1985
sister chromatid exchange human lymphocyte 20 µmol/L MUREAV 77,157,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rat 		lowest published toxic dose: 324 mg/kg/39 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Tumorigenic: Tumors at site of application 		CNREA8 36,1779,1976
subcutaneous
rat 		lowest published toxic dose: 135 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application 		TUMOAB 57,213,1971
subcutaneous
rat 		toxic dose : 135 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		PBPHAW 14,47,1978


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
guinea pig 		lethal dose (75 percent kill): 156 mg/kg N/R 85KYAH 11,852,1989
oral
mouse 		lethal dose (50 percent kill): >12 gm/kg N/R OYYAA2 2,76,1968


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 11,250 mg/kg/90 day- continuous Behavioral: Ataxia

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 37,160,1976
oral
rat 		lowest published toxic dose: 108 gm/kg/90 day- continuous Kidney, Ureter, and Bladder: Other changes

Blood: Other changes

Blood: Changes in leukocyte (WBC) count 		NTIS** OTS0571260


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.012 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Suspected Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 23,205,1980
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 49,49,1990
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 23,205,1980
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 49,49,1990
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMEMDT 49,49,1990


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 0.1 mg(CrO3)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 0.1 mg(CrO3)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 0.1 mg(CrO3)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 0.1 mg(CrO3)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 mg/m3, Carcinogen, JAN1993
Occupational Exposure Limit - AUSTRIA Suspected Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.05 mg/m3, Carcinogen, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.02 mg(Cr)/m3, JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg(Pb)/m3, JAN1999
Occupational Exposure Limit - FINLAND Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE VME 0.05 mg(Cr)/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.15 mg(Pb)/m3, JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.01 mg(Cr)/m3, JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 mg(Pb)/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg(CrO3)/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.05 mg(Pb)/m3, JAN1999
Occupational Exposure Limit - POLAND time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.05 mg(Pb)/m3, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 0.02 mg(Cr)/m3, Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 mg(Cr)/m3, Carcinogen, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.05 mg(Cr)/m3, Carcinogen, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Suspected Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Suspected Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHROMIUM(VI)-air Carcinogen;
10 hour time-weighted average 0.001 mg(Cr)/m3 		NIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO LEAD, INORGANIC-air 10 hour time-weighted average <0.1 mg(Pb)/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81876;
Number of Industries 173;
Total Number of Facilities 12,060;
Number of Occupations 87;
Total Number of Employees Exposed 131,959
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81876;
Number of Industries 33;
Total Number of Facilities 1,628;
Number of Occupations 28;
Total Number of Employees Exposed 31,932;
Total Number of Female Employees Exposed 8,639


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Cell transform.-SA7/SHE
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used to make paint pigments for wood and metal
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 4, 1975/1976
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen


REFERENCES:

CODEN
REFERENCE
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PBPHAW Progress in Biochemical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1965-
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-
TJEMAO Tohoku Journal of Experimental Medicine. (Maruzen Co. Ltd., Export Dept., P.O. Box 5050, Tokyo Int., 100-31 Tokyo, Japan) V.1- 1920-
TUMOAB Tumori. (Casa Editrice Ambrosiana, Via G. Frua 6, 20146 Milan, Italy) V.1- 1911-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used to make paint pigments for wood and metal

NIOSH PROFILE (INORGANIC CHROMIUM COMPOUNDS), SRC, 2/82

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen

ALT CAS #: 8049-64-7
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