The Registry of Toxic Effects of Chemical Substances

Chromic acid, disodium salt

RTECS #: GB2955000

CAS #: 7775-11-3

UPDATE: May 2005 MW: 161.98 MF: CrO4•2Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Chromate of soda
  2. Chromium disodium oxide
  3. Disodium chromate
  4. Neutral sodium chromate
  1. Sodium chromate
  2. Sodium chromate (VI)
  3. Chromium sodium oxide (CrNa2O4)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 2,500 nmol/L MUREAV 260,19,1991
cytogenetic analysis hamster ovary 250 µg/L TXCYAC 17,219,1980
cytogenetic analysis human fibroblast 0.5 µmol/L/24 hour MUREAV 560,79,2004
DNA damage chicken embryo 2,500 nmol/L CRNGDP 4,959,1983
DNA damage hamster lung 200 µmol/L/2 hour- continuous CNREA8 48,1100,1988
DNA damage inhalation
rat 		0.18 mg/m3/6 hour MUREAV 539,109,2003
DNA repair Bacillus subtilis 50 mmol/L TOLED5 7,439,1981
DNA repair inhalation
rat 		0.9 mg/m3/6 hour MUREAV 539,109,2003
DNA repair Salmonella typhimurium 50 mmol/L TOLED5 7,439,1981
mutation in microorganisms Escherichia coli 50 nmol/plate (-enzymatic activation step) NATUAS 250,493,1974
mutation in microorganisms Saccharomyes cerevisiae 25 mmol/L (-enzymatic activation step) TECSDY 23,101,1989
gene conversion and mitotic recombination Saccharomyes cerevisiae 25 mmol/L TECSDY 23,101,1989
mutation in mammalian somatic cells hamster lung 2,500 nmol/L MUREAV 260,19,1991
sister chromatid exchange hamster ovary 250 µg/L TXCYAC 17,219,1980
sister chromatid exchange hamster lung 32 µg/L CRNGDP 4,605,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 5 mg/kg (5 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		TOLED5 51,269,1990


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intradermal
guinea pig 		lowest published lethal dose: 382 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes 		JAPHAR 11,285,1877
intradermal
rabbit 		lowest published lethal dose: 250 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Other changes 		JAPHAR 11,285,1877
intraperitoneal
guinea pig 		lowest published lethal dose: 206 mg/kg N/R AEHLAU 11,201,1965
intraperitoneal
mouse 		lethal dose (50 percent kill): 32 mg/kg N/R COREAF 257,791,1963
intraperitoneal
rat 		lethal dose (50 percent kill): 57 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Coma 		AIPTAK 154,243,1965
intravenous
cat 		lethal dose (50 percent kill): 164 mg/kg Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory depression 		AGSOA6 8,51,1967
intravenous
dog 		lowest published lethal dose: 235 mg/kg N/R EQSSDX 1,1,1975
intravenous
rabbit 		lowest published lethal dose: 32 mg/kg N/R EQSSDX 1,1,1975
oral
rat 		lethal dose (50 percent kill): 136 mg/kg Behavioral: Somnolence (general depressed activity)

Cardiac: Other changes

Skin and Appendages: Other: Hair 		IJTOFN 19,338,2000
subcutaneous
guinea pig 		lowest published lethal dose: 30 mg/kg N/R EQSSDX 1,1,1975
subcutaneous
rabbit 		lowest published lethal dose: 243 mg/kg N/R EQSSDX 1,1,1975
skin
guinea pig 		lowest published lethal dose: 206 mg/kg N/R AEHLAU 11,201,1965


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg(Cr)/m3 DTLVS* TLV/BEI,1999
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed human carcinogen DTLVS* TLV/BEI,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 23,205,1980
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 49,49,1990
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 23,205,1980
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMEMDT 49,49,1990
TOXICOLOGY REVIEW
85DHAX Cr,22,1974


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,101,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg(Cr)/m3 DTLVS* 3,35,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 0.1 mg(CrO3)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 0.1 mg(CrO3)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 0.1 mg(CrO3)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 0.1 mg(CrO3)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - UNITED KINGDOM Carcinogen, SEP2000


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHROMIUM(VI)-air Carcinogen;
10 hour time-weighted average 0.001 mg(Cr)/m3 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 68900;
Number of Industries 69;
Total Number of Facilities 3,942;
Number of Occupations 48;
Total Number of Employees Exposed 34,156
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 68900;
Number of Industries 66;
Total Number of Facilities 3,561;
Number of Occupations 59;
Total Number of Employees Exposed 80,015;
Total Number of Female Employees Exposed 3,487


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive/dose response: TRP reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in leather tanning, wood preservation, corrosion inhibition and pigment manufacture
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen


REFERENCES:

CODEN
REFERENCE
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AGSOA6 Agressologie. Revue Internationale de Physio-Biologie et de Pharmacologie Appliquees aux Effets de l'Agression. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1960-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JAPHAR Journal of Anatomy and Physiology. (London, UK) V.1-50, 1916. For publisher information, see JOANAY.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used in leather tanning, wood preservation, corrosion inhibition and pigment manufacture

NIOSH PROFILE (INORGANIC CHROMIUM COMPOUNDS), SRC, 2/82

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

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