The Registry of Toxic Effects of Chemical Substances
Chloric acid, sodium salt |
UPDATE: November 2003 | MW: 106.44 | MF: ClO3•Na |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
eye rabbit | 10 mg | mild | BIOFX* 24-3/1971 |
skin rabbit | 500 mg/24 hour | mild | BIOFX* 24-3/1971 |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
DNA inhibition |
oral rat | 84 mg/kg/12 week- continuous | JEPOEC 6(1),105,1985 |
mutation in microorganisms | Salmonella typhimurium | 40 µmol/plate (-enzymatic activation step) | MUREAV 90,91,1981 |
sex chromosome loss and nondisjunction |
oral Drosophila melanogaster | 250 mmol/L | MUREAV 90,91,1981 |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation rat | lethal concentration (50 percent kill): >28 gm/m3/1 hour | N/R | BIOFX* 24-3/1971 |
intraperitoneal mouse | lethal dose (50 percent kill): 596 mg/kg | N/R | HBPTO* 2,1412,2001 |
oral cat | lowest published lethal dose: 1,350 mg/kg | N/R | PCOC** -,1013,1966 |
oral cat | lethal dose (50 percent kill): 1,350 mg/kg | N/R | VCVN5* -,384,1989 |
oral dog | lowest published lethal dose: 700 mg/kg | N/R | HBAMAK 4,1289,1935 |
oral dog | lethal dose (50 percent kill): 700 mg/kg | N/R | VCVN5* -,384,1989 |
oral guinea pig | lethal dose (50 percent kill): 6,100 mg/kg | N/R | VCVN1* -,36,1998 |
oral human | lowest published lethal dose: 107.14 mg/kg | N/R | HBPTO* 2,1412,2001 |
oral human | lowest published toxic dose: 5.7 mg/kg |
Vascular: BP lowering not characterized in autonomic section Gastrointestinal: Nausea or vomiting Kidney, Ureter, and Bladder: Renal function tests depressed | VCVN5* -,384,1989 |
oral man | lowest published toxic dose: 286 mg/kg |
Lung, Thorax, or Respiration: Cyanosis Blood: Changes in cell count (unspecified) Blood: Methemoglobinemia- Carboxhemoglobinemia | CTOXAO 15,185,1979 |
oral mouse | lethal dose (50 percent kill): 3,600 mg/kg | N/R | VCVN1* -,36,1998 |
oral rat | lethal dose (50 percent kill): 1,200 mg/kg | N/R | HBPTO* 2,1412,2001 |
oral rabbit | lethal dose (50 percent kill): 7,200 mg/kg | N/R | GTPZAB 31(1),49,1987 |
oral woman | lowest published toxic dose: 800 mg/kg |
Lung, Thorax, or Respiration: Other changes Blood: Other hemolysis with or without anemia Blood: Methemoglobinemia- Carboxhemoglobinemia | 34ZIAG -,539,1969 |
skin rabbit | lethal dose (50 percent kill): >10 gm/kg | N/R | BIOFX* 24-3/1971 |
unreported route child | lethal dose (50 percent kill): 185 mg/kg | N/R | GUCHAZ 6,461,1973 |
unreported route human | lowest published lethal dose: 214 mg/kg | N/R | GUCHAZ 6,461,1973 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
oral dog | lowest published toxic dose: 1,630 mg/kg/5 day- intermittent |
Behavioral: Food intake (animal) Blood: Changes in leukocyte (WBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VETRAX 90,416,1972 |
oral rat | lowest published toxic dose: 495 mg/kg/1 year- continuous |
Blood: Pigmented or nucleated red blood cells Blood: Changes in erythrocyte (RBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JEPOEC 6(1),105,1985 |
oral rat | lowest published toxic dose: 58,819 mg/kg/13 week- continuous |
Brain and Coverings: Changes in brain weight Endocrine: Other changes Blood: Changes in erythrocyte (RBC) count | DCTODJ 18,185,1995 |
oral rat | lowest published toxic dose: 400 mg/kg/4 day- intermittent | Endocrine: Evidence of thyroid hypofunction | JTPAE7 29,250,2001 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
TOXICOLOGY REVIEW |
| JAVMA4 164,277,1974 |
TOXICOLOGY REVIEW |
| JFSCAS 45,474,2000 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 | PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 |
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF | PESTICIDES: Supported | RBREV* -,316,1998 |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Occupational Hazard Survey 1974 |
National Occupational Hazard Survey 1974: Hazard Code: 68870; Number of Industries 15; Total Number of Facilities 334; Number of Occupations 14; Total Number of Employees Exposed 3,058 | |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: 68870![]() Number of Industries 35; Total Number of Facilities 1,023; Number of Occupations 34; Total Number of Employees Exposed 28,583; Total Number of Female Employees Exposed 5,207 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
Used as a constituent of ATRATOL and PRAMITOL | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NTP Carcinogenesis studies; on test (two year studies), October 2000 |
REFERENCES: | |
CODEN |
REFERENCE |
34ZIAG | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 |
BIOFX* | BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062) |
CTOXAO | Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. |
DCTODJ | Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- |
FEREAC | Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- |
GTPZAB | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI |
GUCHAZ | Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada) |
HBAMAK | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) |
HBPTO* | Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001 |
JAVMA4 | Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915- |
JEPOEC | Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984- |
JFSCAS | Journal of Forensic Sciences. (American Soc. for Testing and Materials, 1916 Race St., Philadelphia, PA 19103) V.1- 1956- |
JTPAE7 | Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988 |
MUREAV | Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- |
PCOC** | Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS) |
RBREV* | Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998 |
VCVN1* | "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988. |
VCVN5* | "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989. |
VETRAX | Veterinary Record. (7 Mansfield St., London W1M 0AT, UK) V.1- 1888- |