The Registry of Toxic Effects of Chemical Substances

Cesium hydroxide

RTECS #: FK9800000

CAS #: 21351-79-1

UPDATE: November 2004 MW: 149.92 MF: CsHO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Cesium hydrate
  2. Cesium hydroxide (ACGIH)
  1. Cesium hydroxide dimer


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		5 mg/5 minute rinse severe TXAPA9 32,239,1975
skin
rabbit 		5 mg/24 hour mild TXAPA9 32,239,1975


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		lowest published toxic concentration: 0.4 pph N/R VCVN1* -,59,1998
eye
rabbit 		lowest published toxic concentration: 0.4 pph Eye: Conjunctiva irritation

Eye: Corneal damage

Eye: Other eye effects 		VCVN1* -,59,1998
inhalation
human 		lethal concentration (50 percent kill): 5.02 mg/m3 Skin: After topical application: Primary irritation VCVN1* -,58,1998
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 20.5 mg/m3 Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough 		VCVN1* -,58,1998
intraperitoneal
rat 		lethal dose (50 percent kill): 100 mg/kg N/R AIHOAX 1,637,1950
oral
mouse 		lethal dose (50 percent kill): 800 mg/kg Behavioral: Tetany 20PKA3 -,-,1967
oral
mouse 		lethal dose (50 percent kill): 759 mg/kg N/R VCVN1* -,58,1998
oral
rat 		lethal dose (50 percent kill): 570 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Other changes 		GTPZAB 21(1),29,1977
oral
rat 		lethal dose (50 percent kill): 570 mg/kg N/R VCVN1* -,58,1998
skin
rabbit 		lowest published toxic concentration: 4 pph Eye: Conjunctiva irritation

Eye: Corneal damage

Eye: Other eye effects 		VCVN1* -,59,1998


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 10,110 µg/m3/17 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes 		GTPZAB 21(1),29,1977
inhalation
rat 		lowest published toxic concentration: 10 mg/m3/16 week- continuous Blood: Pigmented or nucleated red blood cells

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in leukocyte (WBC) count 		VCVN1* -,59,1998


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 mg/m3 DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 mg/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 2 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 2 mg/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 2 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 2 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.3 mg/m3, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 2 mg/m3, 2003
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2 mg/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 2 mg/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 2 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CESIUM HYDROXIDE-air 10 hour time-weighted average 2.0 mg/m3 NIOSH* DHHS #95-121,1995


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
20PKA3 "Novye Dannye Po Toksikologii Redkikh Metalov Ikh Soedinenii," New Data on the Toxicology of Rare Metals and Their Compounds, Izrael'son, Z.I., ed., Moscow, Izdatel'stvo "Meditsina," 1967
AIHOAX Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.1-2(3), 1950. For publisher information, see AEHLAU.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

RTECS Compound Description:
   Human Data
   Primary Irritant

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