The Registry of Toxic Effects of Chemical Substances
Castor oil RTECS #: FI4100000
CAS #: 8001-79-4
The Registry of Toxic Effects of Chemical Substances
Castor oil |
| UPDATE: August 2003 | MW: N/R | MF: N/R |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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eye | rabbit
500 mg
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mild
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AJOPAA 29,1363,1946
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skin | guinea pig
100 mg/24 hour
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mild
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CTOIDG 94(8),41,1979
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skin | man
50 mg/48 hour
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mild
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CTOIDG 94(8),41,1979
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skin | rat
100 mg/24 hour
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mild
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CTOIDG 94(8),41,1979
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skin | rabbit
100 mg/24 hour
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severe
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CTOIDG 94(8),41,1979
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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N/R
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N/R
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N/R
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N/R
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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intramuscular | rat
lowest published toxic dose: 1 mL/kg (1 day prior to copulation)
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Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
EKFAE9 57,49,1994
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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intramuscular | rat
lowest published toxic dose: 1 mL/kg
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Endocrine: Effect on menstrual cycle | Reproductive: Maternal effects: Oogenesis Reproductive: Maternal effects: Uterus, cervix, vagina
EKFAE9 57,49,1994
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oral | rat
lowest published toxic dose: 10 mL/kg
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Gastrointestinal: Hypermotility, diarrhea
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JPETAB 299,247,2001
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF
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PESTICIDES: Active registration
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RBREV* -,358,1998
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Occupational Hazard Survey 1974
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National Occupational Hazard Survey 1974: Hazard Code: M1030; | Number of Industries 259; Total Number of Facilities 34,810; Number of Occupations 134; Total Number of Employees Exposed 487,959
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: M1030 |
 ;Number of Industries 195; Total Number of Facilities 32,342; Number of Occupations 136; Total Number of Employees Exposed 444,011; Total Number of Female Employees Exposed 172,359 | ||||
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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Used as a chemical intermediate, cosmetic, perfume ingredient, pharmaceutical
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EPA TSCA Section 8(d) unpublished health/safety studies
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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NTP Toxicity studies, RPT# TOX-12, October 2000
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REFERENCES:
CODEN
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REFERENCE
AJOPAA
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American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415,
Chicago, IL 60611) Series 3: V.1- 1918-
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CTOIDG
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Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976-
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EKFAE9
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Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology.
(Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992-
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JPETAB
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Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E.
Preston St., Baltimore, MD 21202) V.1- 1909/10-
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RBREV*
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Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report),
Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental
Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
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