The Registry of Toxic Effects of Chemical Substances

Carbonochloridic acid, methyl ester

RTECS #: FG3675000

CAS #: 79-22-1

UPDATE: July 2000 MW: 94.50 MF: C2H3ClO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Chlorameisensaeure methylester (German)
  2. Chlorocarbonate de methyle (French)
  3. Chlorocarbonic acid methyl ester
  4. Chloroformiate de methyle (French)
  5. Chloroformic acid methyl ester
  6. Formic acid, chloro - , methyl ester
  7. MCF
  8. Methoxycarbonyl chloride
  1. Methylchloorformiaat (Dutch)
  2. Methyl chlorocarbonate
  3. Methylester kyseliny chlormravenci (Czech)
  4. Methylester kyseliny chloruhlicite (Czech)
  5. Metilcloroformiato (Italian)
  6. RCRA waste number U156
  7. TL 438


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published lethal concentration: 1,500 mg/m3/30 minute N/R GISAAA 42(5),97,1977
inhalation
man 		lowest published toxic concentration: 5 mg/m3 Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes 		GISAAA 42(5),97,1977
inhalation
mouse 		lethal concentration (50 percent kill): 185 mg/m3/2 hour Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Behavioral: Muscle weakness 		GISAAA 42(5),97,1977
inhalation
rat 		lethal concentration (50 percent kill): 88 ppm/1 hour N/R TXAPA9 42,417,1977
intraperitoneal
mouse 		lethal dose (50 percent kill): 40 mg/kg N/R NTIS** AD691-490
oral
guinea pig 		lethal dose (50 percent kill): 140 mg/kg N/R GISAAA 42(5),97,1977
oral
mouse 		lethal dose (50 percent kill): 67 mg/kg N/R GISAAA 42(5),97,1977
oral
rat 		lethal dose (50 percent kill): 60 mg/kg N/R GISAAA 42(5),97,1977
skin
mouse 		lethal dose (50 percent kill): 1,750 mg/kg N/R GISAAA 42(5),97,1977
skin
rabbit 		lethal dose (50 percent kill): 7,120 mg/kg N/R TXAPA9 42,417,1977


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 640 µg/m3/17 week- intermittent Blood: Other changes

Nutritional and Gross Metabolic: Body temperature decrease 		GISAAA 42(5),97,1977
inhalation
rat 		lowest published toxic concentration: 34,360 µg/m3/6 hour/4 week- intermittent Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0570775
inhalation
rat 		lowest published toxic concentration: 720 µg/m3/17 week- intermittent Cardiac: Changes in heart weight

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Body temperature decrease 		GISAAA 42(5),97,1977


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 0.05 mg/m3, Skin, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4785;
Number of Industries 2;
Total Number of Facilities 257;
Number of Occupations 4;
Total Number of Employees Exposed 3,949;
Total Number of Female Employees Exposed 408


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in synthesis of pharmaceuticals, herbicides, plastics and other organic chemicals
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used in synthesis of pharmaceuticals, herbicides, plastics and other organic chemicals

RTECS Compound Description:
   Human Data

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