The Registry of Toxic Effects of Chemical Substances

Carbazic acid, 3 - (2 - quinoxalinylmethylene) - , methyl ester, N (sup 1) ,N (sup 4) - dioxide

RTECS #: FE2779000

CAS #: 6804-07-5

UPDATE: November 2004 MW: 262.25 MF: C11H10N4O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STANDARDS AND REGULATIONS:
  8. REFERENCES:

SYNONYMS:

  1. Carbadox
  2. 3 - (2 - Chinoxalinylmethylen - 1,4 - dioxid) methylkarbazat (Czech)
  3. 2 - Formylquinoxaline 1,4 - dioxide carbomethoxyhydrazone
  4. Fortigro
  5. Getroxel
  1. GS 6244
  2. Hydrazinecarboxylic acid, (2 - quinoxalinylmethylene) - , methyl ester, N,N' - dioxide (9CI)
  3. Karbadox (Czech)
  4. Mecadox
  5. Methyl 3 - (2 - quinoxalinylmethylene) carbazate - N1,N4 - dioxide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis oral
mouse 		100 mg/kg MUREAV 117,311,1983
DNA inhibition human other cell types 50 mg/L JTEHD6 10,143,1982
DNA repair Bacillus subtilis 1 µg/disc MUREAV 90,49,1981
DNA repair Salmonella typhimurium 100 µg/disc MUREAV 90,49,1981
unscheduled DNA synthesis rat liver 38 µmol/L MUREAV 221,263,1989
mutation in microorganisms Escherichia coli 2 µg/plate (+enzymatic activation step) MUREAV 217,203,1989
mutation in microorganisms Salmonella typhimurium 50 nmol/plate (+/-enzymatic activation step) CPBTAL 28,1347,1980
micronucleus test oral
mouse 		100 mg/kg MUREAV 144,81,1985
micronucleus test intraperitoneal
mouse 		100 mg/kg MUREAV 144,81,1985
micronucleus test intraperitoneal
rat 		10 mg/kg MUREAV 116,129,1983
other mutation test systems Escherichia coli 100 µg/L MUREAV 131,101,1984
sister chromatid exchange hamster lung 2 mg/L MUREAV 139,199,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 800 mg/kg (8-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TOLED5 129,115,2002
oral
rat 		lowest published toxic dose: 200 mg/kg (8-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOLED5 129,115,2002
oral
rat 		lowest published toxic dose: 800 mg/kg (8-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death 		TOLED5 129,115,2002


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 5,475 mg/kg/1 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		IGSBAL 127,283,1993


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lethal dose (50 percent kill): 2,810 mg/kg N/R CKFRAY 30,26,1981
oral
rat 		lethal dose (50 percent kill): 850 mg/kg N/R CKFRAY 30,26,1981


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 80 mg/kg/8 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOLED5 129,115,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.003 mg/m3, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
CKFRAY Cesko-Slovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1-42, 1952-93. For publisher information, see CSLFEK
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958-
IGSBAL Igaku to Seibutsugaku. Medicine and Biology. (c/o Ogato Igaku Kagaku Kenkyusho, 2-3-5 Bakuro-cho, Nihonbashi, Chuo-ku, Tokyo 103, Japan) V.1- 1942-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector

ALT CAS #: 39310-25-3
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