The Registry of Toxic Effects of Chemical Substances

Carbanilic acid, m - chloro - , isopropyl ester

RTECS #: FD8050000

CAS #: 101-21-3

UPDATE: May 2005 MW: 213.68 MF: C10H12ClNO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Bud Nip
  2. Bygran
  3. Carbamic acid, (3 - chlorophenyl) - , 1 - methylethyl ester (9CI)
  4. N - (3 - Chloor - fenyl) - isopropyl carbamaat (Dutch)
  5. Chlor IFC
  6. Chlor IFK
  7. Chlor IPC
  8. m - Chlorocarbanilic acid, isopropyl ester
  9. 3 - Chlorocarbanilic acid, isopropyl ester
  10. Chloro - IPC
  11. N - (3 - Chloro phenyl) carbamate d'isopropyle (French)
  12. N - (3 - Chlorophenyl) carbamic acid, isopropyl ester
  13. (3 - Chlorophenyl) carbamic acid, 1 - methylethyl ester
  14. Chloropropham
  15. N - (3 - Chlor - phenyl) - isopropyl - carbamat (German)
  16. Chlorpropham
  17. Chlorprophame (French)
  18. CI - IFK
  19. CIPC
  20. N - (3 - Cloro - fenil) - isopropil - carbammato (Italian)
  21. Elbanil
  22. ENT 18,060
  23. Fasco WY - hoe
  24. Furloe
  1. Furloe 4EC
  2. Isopropyl meta - chlorocarbanilate
  3. Isopropyl 3 - chlorocarbanilate
  4. Isopropyl - N - m - chlorophenyl - carbamate
  5. Isopropyl 3 - chlorophenylcarbamate
  6. Isopropyl - N - (3 - chlorophenyl) carbamate
  7. O - Isopropyl N - (3 - chlorophenyl) carbamate
  8. Isopropyl - N - (3 - chlorphenyl) - carbamat (German)
  9. Keim - stop
  10. Liro CIPC
  11. 1 - Methylethyl (3 - chlorophenyl) carbamate
  12. Metoxon
  13. Mirvale
  14. Nexoval
  15. Preventol
  16. Preventol 56
  17. Sprout nip
  18. Sprout - nip EC
  19. Stopgerme - S
  20. Taterpex
  21. Triherbicide CIPC
  22. Unicrop CIPC
  23. Y 3


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
unscheduled DNA synthesis human fibroblast 4 mg/L PMRSDJ 1,528,1981
unscheduled DNA synthesis human lymphocyte 30 mg/L ABILAE 92,367,1981
mutation in microorganisms Saccharomyes cerevisiae 100 mg/L (-enzymatic activation step) PMRSDJ 1,414,1981
mutation in mammalian somatic cells mouse lymphocyte 31,500 µg/L PMRSDJ 1,580,1981
morphological transform hamster kidney 2,500 µg/L PMRSDJ 1,638,1981
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 25 mg/L PMRSDJ 1,468,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 3 gm/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		REPTED 11,697,1997
subcutaneous
mouse 		lowest published toxic dose: 9 gm/kg (6-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** PB223-160


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 600 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors 		BJCAAI 12,355,1958


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 2,600 mg/kg N/R CRSBAW 175,496,1981
intraperitoneal
rat 		lethal dose (50 percent kill): 700 mg/kg N/R CRSBAW 175,496,1981
oral
mouse 		lethal dose (50 percent kill): 3,650 mg/kg N/R FACOEB 16,173,1999
oral
rat 		lethal dose (50 percent kill): 1,200 mg/kg Eye: Other eye effects

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression 		AEHLAU 19,621,1969
oral
rabbit 		lethal dose (50 percent kill): 5 gm/kg N/R PAREAQ 14,225,1962
unreported route
duck 		lethal dose (50 percent kill): >2 gm/kg N/R FMCHA2 -,C73,1991
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 3 gm/kg N/R 30ZDA9 -,200,1971
unreported route
rat 		lethal dose (50 percent kill): 3,350 mg/kg N/R EQSSDX 3,618,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 789 gm/kg/1 year- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXAPA9 2,659,1960
oral
rat 		lowest published toxic dose: 1,092 gm/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 2,659,1960
oral
rat 		lowest published toxic dose: 68,250 mg/kg/13 week- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Methemoglobinemia- Carboxhemoglobinemia 		TXCYAC 123,111,1997
oral
rat 		lowest published toxic dose: 126 gm/kg/2 week- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count 		FCTOD7 39,353,2001
oral
rat 		lowest published toxic dose: 252 gm/kg/4 week- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count 		FCTOD7 39,353,2001
oral
rat 		lowest published toxic dose: 378 gm/kg/6 week- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count 		FCTOD7 39,353,2001
oral
rat 		lowest published toxic dose: 504 gm/kg/8 week- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count 		FCTOD7 39,353,2001
oral
rat 		lowest published toxic dose: 819 gm/kg/13 week- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count 		FCTOD7 39,353,2001
oral
rat 		lowest published toxic dose: 3,276 mg/kg/13 week- continuous Blood: Changes in spleen FCTOD7 42,1469,2004
oral
rat 		lowest published toxic dose: 16.4 gm/kg/13 week- continuous Endocrine: Changes in spleen weight

Blood: Normocytic anemia

Blood: Changes in bone marrow not included in above 		FCTOD7 42,1469,2004
oral
rat 		lowest published toxic dose: 81.9 mg/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight 		FCTOD7 42,1469,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 12,55,1976
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 12,55,1976
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
RREVAH 63,1,1976


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,99,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
Used as a highly selective pre-emergence and early post-emergence herbicide
On EPA IRIS database


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
ABILAE Archives de Biologie (1880-1985). (Liege, Belgium) V.1-96(1), 1880-1985.
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
FACOEB Food Additives and Contaminants. (Taylor & Francis Inc., 242 Cherry St., Philadelphia, PA 19106) V.1- 1984-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PAREAQ Pharmacological Reviews. (Williams & Wilkins, 428 E. Preston St., Baltimore, MD 21202) V.1- 1949-
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as a highly selective pre-emergence and early post-emergence herbicide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector

ALT CAS #: 11097-02-2
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