The Registry of Toxic Effects of Chemical Substances

Carbamoyl chloride, dimethyl -

RTECS #: FD4200000

CAS #: 79-44-7

UPDATE: May 2005 MW: 107.55 MF: C3H6ClNO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. (Dimethylamino) carbonyl chloride
  2. Carbamic acid, dimethyl - (9CI)
  3. Carbamyl chloride, N,N - dimethyl -
  4. Chlorid kyseliny dimethylkarbaminove (Czech)
  5. Chloroformic acid dimethylamide
  6. Dimethyl carbamoyl chloride
  7. Dimethyl carbamoyl chloride (ACGIH)
  8. Dimethylamid kyseliny chlormravenci (Czech)
  9. Dimethylcarbamic acid chloride
  10. Dimethylcarbamic chloride
  11. Dimethylcarbamidoyl chloride
  1. Dimethylcarbamoyl chloride
  2. Dimethylcarbamyl chloride
  3. Dimethylchloroformamide
  4. Dimethylkarbamoylchlorid (Czech)
  5. N,N - Dimethylaminocarbonyl chloride
  6. N,N - Dimethylcarbamic acid chloride
  7. N,N - Dimethylcarbamidoyl chloride
  8. N,N - Dimethylcarbamoyl chloride
  9. N,N - Dimethylcarbamyl chloride
  10. RCRA waste number U097
  11. TL 389


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 33 µL/L PMRSDJ 1,551,1981
DNA repair Escherichia coli 10 mg/L JJIND8 62,873,1979
DNA repair Saccharomyes cerevisiae 136 µmol/L CNJGA8 24,771,1982
DNA repair Schizosaccharomyces pombe 136 µmol/L CNJGA8 24,771,1982
unscheduled DNA synthesis human fibroblast 32 µg/L PMRSDJ 1,528,1981
host-mediated assay mouse
Salmonella typhimurium 		1 gm/kg JJIND8 62,911,1979
mutation in microorganisms Escherichia coli 100 µg/plate (+/-enzymatic activation step) ENMUDM 6(Suppl 2),1,1984
mutation in microorganisms mouse lymphocyte 187 mg/L (+enzymatic activation step) MUREAV 97,49,1982
mutation in microorganisms Salmonella typhimurium 33 µg/plate (+enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms Salmonella typhimurium 300 ng/plate (-enzymatic activation step) ENMUDM 6(Suppl 2),1,1984
mutation in microorganisms Saccharomyes cerevisiae 89 mg/L (+enzymatic activation step) PMRSDJ 1,414,1981
mutation in microorganisms Schizosaccharomyces pombe 2 mg/L (+/-enzymatic activation step) PMRSDJ 1,424,1981
micronucleus test intraperitoneal
mouse 		1,400 µg/kg PMRSDJ 1,698,1981
gene conversion and mitotic recombination Saccharomyes cerevisiae 2 gm/L PMRSDJ 1,481,1981
mutation in mammalian somatic cells mouse lymphocyte 1,200 mg/L PMRSDJ 1,580,1981
morphological transform hamster kidney 80 µg/L BJCAAI 37,873,1978
morphological transform hamster embryo 100 µg/L IJCNAW 19,642,1977
other mutation test systems Escherichia coli 540 pmol/tube MUREAV 147,79,1985
phage inhibition capacity Escherichia coli 500 µL/L PMRSDJ 1,224,1981
sister chromatid exchange hamster ovary 100 µmol/L MUREAV 118,103,1983
sister chromatid exchange hamster lung 100 µmol/L MUREAV 118,103,1983
sex chromosome loss and nondisjunction parenteral
Drosophila melanogaster 		10 pph ENMUDM 7,349,1985
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 100 mg/L PMRSDJ 1,468,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
hamster 		lowest published toxic concentration: 1 ppm/6 hour/89 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JEPTDQ 4(1),107,1980
inhalation
hamster 		toxic concentration (other than lowest) : 1 ppm/6 hour/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors 		JEPTDQ 4(1),107,1980
inhalation
rat 		lowest published toxic concentration: 1 ppm/6 hour/6 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors 		CALEDQ 33,175,1986
inhalation
rat 		toxic concentration (other than lowest) : 1 ppm/6 hour/6 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		PAACA3 21,106,1980
inhalation
rat 		toxic concentration (other than lowest) : 1 ppm Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors 		OHSLAM 6,5,1976
intraperitoneal
mouse 		lowest published toxic dose: 2,560 mg/kg/64 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application 		JNCIAM 53,695,1974
subcutaneous
mouse 		lowest published toxic dose: 894 mg/kg/52 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		JACTDZ 6(4),479,1987
subcutaneous
mouse 		toxic dose : 8 gm/kg/40 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application 		JNCIAM 53,695,1974
subcutaneous
mouse 		toxic dose : 5,200 mg/kg/26 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application 		JNCIAM 48,1539,1972
skin
mouse 		lowest published toxic dose: 17,280 mg/kg/72 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		JACTDZ 6(4),479,1987
skin
mouse 		toxic dose : 13 gm/kg/55 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors 		JNCIAM 48,1539,1972
skin
mouse 		toxic dose : 13 gm/kg/55 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		JNCIAM 53,695,1974


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published lethal concentration: 1,000 mg/m3/10 minute N/R NDRC** NDCrc-132,OCT1942
inhalation
rat 		lethal concentration (50 percent kill): 180 ppm/6 hour N/R JEPTDQ 4(1),107,1980
intraperitoneal
mouse 		lethal dose (50 percent kill): 300 mg/kg Behavioral: Somnolence (general depressed activity) ZAARAM 24,71,1974
oral
rat 		lethal dose (50 percent kill): 1 gm/kg Behavioral: Somnolence (general depressed activity) ZAARAM 24,71,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average L DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Suspected Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 12,77,1976
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,531,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 12,77,1976
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 71,531,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2A IMEMDT 71,531,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA Carcinogen, JAN1993
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM Carcinogen, JAN1993
Occupational Exposure Limit - FINLAND Carcinogen, JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND Carcinogen, JAN1999
Occupational Exposure Limit - UNITED KINGDOM Carcinogen, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Suspected Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Suspected Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIMETHYLCARBAMOYLCHLORIDE-air Carcinogen lowest feasible conc. NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay; Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a chemical intermediate in the production of drugs and pesticides
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 11, 1976
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CNJGA8 Canadian Journal of Genetics and Cytology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 1959-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NDRC** National Defense Research Committee, Office of Scientific Research and Development, Progress Report.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
OHSLAM Occupational Health and Safety Letter. (Environews, Inc., 1097 National Press Bldg., Washington, DC 20045) V.1- 1970-
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981-
ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed. Rep. Ger.) V.1-25, 1951-75.

Used as a chemical intermediate in the production of drugs and pesticides

NIOSH PROFILE (DIMETHYL and DIETHYL CARBAMOYL CHLORIDE), SRC, 4/7

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen

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