The Registry of Toxic Effects of Chemical Substances

Carbamic acid, methyl - , 2,3 - dihydro - 2,2 - dimethyl - 7 - benzofuranyl ester

RTECS #: FB9450000

CAS #: 1563-66-2

UPDATE: February 2005 MW: 221.28 MF: C12H15NO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2,2 - Dimethyl - 2,3 - dihydro - 7 - benzofuranyl N - methylcarbamate
  2. 2,2 - Dimethyl - 7 - coumaranyl N - methylcarbamate
  3. 2,3 - Dihydro - 2,2 - dimethyl - 7 - benzofuranyl methylcarbamate
  4. 2,3 - Dihydro - 2,2 - dimethylbenzofuran - 7 - yl methylcarbamate
  5. 2,3 - Dihydro - 2,2 - dimethylbenzofuranyl - 7 - N - methylcarbamate
  6. 7 - Benzofuranol, 2,3 - dihydro - 2,2 - dimethyl - , methylcarbamate (9CI)
  7. BAY 70143
  8. C2292 - 59A
  9. Carbamic acid, methyl - , 2,2 - dimethyl - 2,3 - dihydrobenzofuran - 7 - yl ester
  10. Carbofuran
  11. Carbofuran (ACGIH)
  12. Carbofurane
  13. Chinufur
  14. Crisfuran
  15. Curaterr
  16. D 1221
  17. ENT 27,164
  18. FMC 10242
  1. Furacarb
  2. Furadan
  3. Furadan 3G
  4. Furadan 4F
  5. Furadan 75 WP
  6. Furadane
  7. Furodan
  8. Karbofuranu (Polish)
  9. ME F248
  10. Methyl carbamic acid 2,3 - dihydro - 2,2 - dimethyl - 7 - benzofuranyl ester
  11. N - Metylokarbaminian 2,3 - dwuwodoro - 2,2 - dwumetylobenzofuranylu - 7 (Polish)
  12. NIA 10242
  13. NIA 10242 75 WP
  14. Niagara 10242
  15. Niagara nia - 10242
  16. OMS - 864
  17. Yaltox


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human lymphocyte 100 mg/L TGANAK 18(1),17,1984
cytogenetic analysis oral
mouse 		3,800 µg/kg MUREAV 465,123,2000
mutation in microorganisms other microorganisms 60 mg/L (-enzymatic activation step) MILEDM 12,79,1979
mutation in microorganisms Salmonella typhimurium 10 mg/plate (+/-enzymatic activation step) MUREAV 116,185,1983
mutation in mammalian somatic cells hamster lung 500 µmol/L ENVRAL 29,48,1982
other mutation test systems oral
mouse 		5,700 µg/kg MUREAV 465,123,2000
sister chromatid exchange human lymphocyte 5 mg/L MUREAV 147,296,1985
sperm morphology intraperitoneal
mouse 		2 mg/kg MUREAV 465,123,2000


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
man 		lowest published toxic dose: 6,200 µg/kg (multigeneration) Reproductive: Effects on newborn: Delayed effects JRPFA4 113,95,1998
oral
mouse 		lowest published toxic dose: 210 µg/kg (1-21 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic JEPTDQ 2(2),357,1978
oral
mouse 		lowest published toxic dose: 10,500 µg/kg (1-21 day pregnant) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects 		JEPTDQ 4(5-6),53,1980
oral
mouse 		lowest published toxic dose: 220 mg/kg (6-16 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system JPFCD2 20,373,1985
oral
mouse 		lowest published toxic dose: 110 mg/kg (6-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		JPFCD2 20,373,1985
oral
rat 		lowest published toxic dose: 70 mg/kg (6-19 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		JPFCD2 20,373,1985
oral
rat 		lowest published toxic dose: 86 mg/kg (60 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		HETOEA 14,889,1995


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lethal concentration (50 percent kill): 52 mg/m3 Eye: Other eye effects

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Nausea or vomiting 		JJOMDZ 12,16,1970
inhalation
guinea pig 		lethal concentration (50 percent kill): 43 mg/m3/4 hour Eye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		BIOFX* N5182,1967
inhalation
rat 		lethal concentration (50 percent kill): 85 mg/m3 Eye: Other eye effects

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Nausea or vomiting 		JJOMDZ 12,16,1970
intravenous
mouse 		lethal dose (50 percent kill): 450 µg/kg N/R CSLNX* NX#11280
oral
wild bird 		lethal dose (50 percent kill): 420 µg/kg N/R TXAPA9 26,154,1973
oral
chicken 		lethal dose (50 percent kill): 6,300 µg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia 		TXAPA9 11,49,1967
oral
duck 		lethal dose (50 percent kill): 415 µg/kg N/R TXAPA9 22,556,1972
oral
dog 		lethal dose (50 percent kill): 19 mg/kg Eye: Other eye effects

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Nausea or vomiting 		JJOMDZ 12,16,1970
oral
dog 		lethal dose (50 percent kill): 19 mg/kg N/R HBPTO* 2,1094,2001
oral
man 		lowest published toxic dose: 1,428.6 µL/kg Peripheral Nerve and Sensation: Paresthesia

Eye: Miosis (pupilliary constriction)

Nutritional and Gross Metabolic: Body temperature increase 		JTCTDW 38,43,2000
oral
man 		lowest published toxic dose: 1.43 mL/kg Peripheral Nerve and Sensation: Paresthesia

Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Muscle weakness 		JTCTDW 38,43,2000
oral
mouse 		lethal dose (50 percent kill): 2 mg/kg N/R HBPTO* 2,1094,2001
oral
pigeon 		lethal dose (50 percent kill): 1,330 µg/kg N/R ASTTA8 (680),157,1979
oral
quail 		lethal dose (50 percent kill): 3,160 µg/kg N/R ASTTA8 (680),157,1979
oral
rat 		lethal dose (50 percent kill): 5 mg/kg N/R PSSCBG 1,117,1970
oral
rat 		lethal dose (50 percent kill): 8 mg/kg Behavioral: Convulsions or effect on seizure threshold

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) 		EKFAE9 55,51,1992
oral
rat 		lowest published toxic dose: 0.5 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOXID9 72,305,2003
oral
woman 		lowest published toxic dose: 1,200 µg/kg Behavioral: Hallucinations, distorted perceptions

Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Sweating 		KHZDAN 24,445,1981
skin
wild bird 		lethal dose (50 percent kill): 100 mg/kg N/R TXAPA9 26,154,1973
skin
mammal (species unspecified) 		lethal dose (50 percent kill): 837 mg/kg Olfaction: Other olfaction effects

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands 		GISAAA 53(2),89,1988
skin
rat 		lethal dose (50 percent kill): 120 mg/kg N/R WRPCA2 9,119,1970
skin
rabbit 		lethal dose (50 percent kill): 885 mg/kg N/R GUCHAZ 6,81,1973
unreported route
mouse 		lethal dose (50 percent kill): 5 mg/kg N/R GISAAA 49(10),23,1984
unreported route
rat 		lethal dose (50 percent kill): 19 mg/kg N/R GISAAA 49(10),23,1984
unreported route
rat 		lethal dose (50 percent kill): 8 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) FATOAO 50,97,1987
unreported route
rabbit 		lethal dose (50 percent kill): 885 mg/kg N/R 30ZDA9 -,192,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mammal (species unspecified) 		lowest published toxic dose: 10.5 mg/kg/6 week- intermittent Blood: Other changes HBPTO* 1,776,2001
intraperitoneal
mouse 		lowest published toxic dose: 3 mg/kg/6 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		TXCYAC 38,69,1986
oral
wild bird 		lowest published toxic dose: 71,600 µg/kg/7 day- continuous Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		AECTCV 11,611,1982
oral
chicken 		lowest published toxic dose: 1,960 mg/kg/2 week- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TXAPA9 11,49,1967
oral
dog 		lowest published toxic dose: 4,550 mg/kg/1 year- continuous Blood: Other changes

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		RCTOE4 104,35,1988
oral
mouse 		lowest published toxic dose: 13,686 mg/kg/2 year- continuous Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		RCTOE4 104,35,1988
oral
mouse 		lowest published toxic dose: 39 mg/kg/30 day- intermittent Reproductive: Maternal effects: Oogenesis

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in ovarian weight 		BECTA6 71,422,2003
oral
rat 		lowest published toxic dose: 21 mg/kg/30 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS 		BCTKAG 14,289,1981
oral
rat 		lowest published toxic dose: 3,640 mg/kg/2 year- continuous Brain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		RCTOE4 104,35,1988
oral
rabbit 		lowest published toxic dose: 0.99 mg/kg/33 day- continuous Immunological Including Allergic: Decrease in humoral immune response TXAPA9 32,587,1975
oral
rabbit 		lowest published toxic dose: 1.71 mg/kg/57 day- continuous Blood: Changes in spleen TXAPA9 32,587,1975
oral
rabbit 		lowest published toxic dose: 1.32 mg/kg/44 day- continuous Immunological Including Allergic: Decreased immune response TXAPA9 32,587,1975
skin
rabbit 		lowest published toxic dose: 17 gm/kg/20 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JJOMDZ 12,16,1970


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
JAVMA4 164,277,1974
TOXICOLOGY REVIEW
TOLED5 128,45,2002
TOXICOLOGY REVIEW
MUREAV 562,77,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,94,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg/m3, JAN1993
Occupational Exposure Limit - INDIA time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.1 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, 2003
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CARBOFURAN-air 10 hour time-weighted average 0.1 mg/m3 NIOSH* DHHS #95-121,1995


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a systemic acaricide, insecticide and nematicide
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062)
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992-
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915-
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JJOMDZ JOM, Journal of Occupational Medicine. (American Occupational Medicine Assoc., 150 N. Wacker Dr., Chicago, IL 60606) V.10- 1968-
JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.B11- 1976-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.9- 1966-
MILEDM Microbios Letters. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PSSCBG Pesticide Science. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1970-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RCTOE4 Reviews of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.98- 1987-
TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used as a systemic acaricide, insecticide and nematicide

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector
   Human Data

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