The Registry of Toxic Effects of Chemical Substances

Carbamic acid, diisopropylthio - , S - (2,3,3 - trichloroallyl) ester

RTECS #: EZ8575000

CAS #: 2303-17-5

UPDATE: February 2004 MW: 304.68 MF: C10H16Cl3NOS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 2,3,3 - Trichlorallyl - N,N - (diisopropyl) - thiocarbamat (German)
  2. 2,3,3 - Trichloroallyl diisopropylthiocarbamate
  3. 2 - Propene - 1 - thiol, 2,3,3 - trichloro - , diisopropylcarbamate
  4. Avadex BW
  5. CP 23426
  6. Diisopropyltrichloroallylthiocarbamate
  7. Dipthal
  8. Far - Go
  1. N,N - Diisopropyl - 2,3,3 - trichlorallyl - thiolcarbamat (German)
  2. N - Diisopropylthiocarbamic acid S - 2,3,3 - trichloro - 2 - propenyl ester
  3. S - 2,3,3 - Trichloroallyl N,N - diisopropylthiocarbamate
  4. S - 2,3,3 - Trichloroallyl diisopropylthiocarbamate
  5. Thiocarbamic acid, N - diisopropyl - , S - 2,3,3 - trichloroallyl ester
  6. Triallat (German)
  7. Triallate
  8. Triamyl


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 100 µmol/L MUREAV 85,45,1981
DNA inhibition human lymphocyte 100 mg/L ARTODN 45,101,1980
DNA inhibition rat other cell types 100 mg/L ARTODN 45,101,1980
mutation in microorganisms Bacillus subtilis 100 µg/plate (+enzymatic activation step) JAFCAU 29,268,1981
mutation in microorganisms Escherichia coli 5 mg/L (-enzymatic activation step) GNKAA5 22,2416,1986
mutation in microorganisms other microorganisms 4,800 µg/plate (-enzymatic activation step) CBINA8 22,297,1978
mutation in microorganisms Salmonella typhimurium 4,800 µg/plate (+enzymatic activation step) MUREAV 57,277,1978
mutation in microorganisms Salmonella typhimurium 100 nmol/plate (-enzymatic activation step) BCPCA6 32,3739,1983
gene conversion and mitotic recombination Saccharomyes cerevisiae 40 ppm NTIS** PB84-138973
mutation in mammalian somatic cells mouse lymphocyte 10 mg/L NTIS** PB84-138973
sister chromatid exchange hamster ovary 20 µmol/L MUREAV 85,45,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
unreported route
mammal (species unspecified) 		lowest published toxic dose: 30 mg/kg (multigenerations) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) 		FEREAC 65,58376,2000


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published lethal concentration: 400 mg/m3/4 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal) 		GISAAA 33(7),37,1968
oral
mouse 		lethal dose (50 percent kill): 930 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Muscle contraction or spasticity 		GISAAA 33(7),37,1968
oral
quail 		lethal dose (50 percent kill): 2,251 mg/kg N/R PEMNDP 9,835,1991
oral
rat 		lethal dose (50 percent kill): 800 mg/kg N/R 85JFAN A403,1984
skin
rat 		lowest published lethal dose: 3,500 mg/kg N/R GISAAA 33(7),37,1968
skin
rabbit 		lethal dose (50 percent kill): 2,225 mg/kg N/R 28ZEAL 5,226,1976
unreported route
dog 		lethal dose : >20 gm/kg N/R 85JFAN A403,1984
unreported route
mouse 		lethal dose (50 percent kill): 832 mg/kg N/R TGANAK 16(1),45,1982
unreported route
rat 		lethal dose (50 percent kill): 1,471 mg/kg N/R EQSSDX 3,618,1975
unreported route
rat 		lowest published toxic dose: 300 mg/kg Behavioral: Food intake (animal)

Behavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FEREAC 65,58377,2000


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 40 mg/m3/4 hour/17 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) GISAAA 33(7),37,1968
oral
rat 		lowest published toxic dose: 17,493 mg/kg/17 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field GISAAA 33(7),37,1968


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,214,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
Used for preemergence control of wild oats
On EPA IRIS database


REFERENCES:

CODEN
REFERENCE
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GNKAA5 Genetika (Moscow). For English translation, see SOGEBZ. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1965-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967-

Used for preemergence control of wild oats

RTECS Compound Description:
   Agricultural Chemical
   Mutagen

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