The Registry of Toxic Effects of Chemical Substances
Carbamic acid, diethyldithio - , sodium salt |
UPDATE: November 2004 | MW: 171.27 | MF: C5H10NS2翝a |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
cytogenetic analysis |
oral rat | 5,200 mg/kg | MUREAV 53,212,1978 |
DNA damage | human HeLa cell | 100 痠ol/L | BBACAQ 519,65,1978 |
DNA damage | mouse lymphocyte | 1,500 痠ol/L | MUREAV 203,155,1988 |
DNA inhibition | rat other cell types | 1 mg/L | CBINA8 64,151,1987 |
DNA inhibition |
intraperitoneal rat | 500 mg/kg | CBINA8 64,151,1987 |
other mutation test systems | other microorganisms | 100 痠ol/L | BBACAQ 519,65,1978 |
specific locus test | mouse lymphocyte | 31 痢/L | EMMUEG 17,196,1991 |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
intraperitoneal dog | lowest published toxic dose: 100 mg/kg (1 day male) | Reproductive: Other effects on male | NYKZAU 75,425,1979 |
intraperitoneal dog | lowest published toxic dose: 50 mg/kg (1 day male) | Reproductive: Other effects on male | ANDRDQ 12,85,1980 |
intraperitoneal rat | lowest published toxic dose: 2,100 mg/kg (7 day male) |
Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Other effects on male Endocrine: Androgenic | ANDRDQ 17,400,1985 |
subcutaneous mouse | lowest published toxic dose: 1,935 mg/kg (6-14 day pregnant) |
Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | NTIS** PB223-160 |
subcutaneous mouse | lowest published toxic dose: 1,935 mg/kg (6-14 day pregnant) |
Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) | NTIS** PB223-160 |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
oral mouse | lowest published toxic dose: 76 gm/kg/78 week- intermittent |
Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors Liver: Tumors | NTIS** PB223-159 |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
intraperitoneal mouse | lethal dose (50 percent kill): 1,032 mg/kg | N/R | PHTOEH 64,247,1989 |
intraperitoneal rat | lethal dose (50 percent kill): 1,250 mg/kg | N/R | PHARAT 27,139,1972 |
oral mouse | lethal dose (50 percent kill): 1,500 mg/kg | N/R | DRFUD4 6,225,1981 |
oral rat | lethal dose (50 percent kill): 1,500 mg/kg | N/R | DRFUD4 6,225,1981 |
oral rabbit | lethal dose (50 percent kill): 500 mg/kg | N/R | FATOAO 32,356,1969 |
skin rat | lethal dose (50 percent kill): >1 gm/kg | N/R | WRPCA2 9,119,1970 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
oral chicken | lowest published toxic dose: 9,900 mg/kg/30 day- intermittent | Behavioral: Ataxia | PCBPBS 19,243,1983 |
oral mouse | lowest published toxic dose: 7 gm/kg/7 day- intermittent |
Endocrine: Changes in spleen weight Endocrine: Changes in thymus weight | JTEHD6 37,559,1992 |
subcutaneous mouse | lowest published toxic dose: 100 mg/kg/4 day- intermittent |
Immunological Including Allergic: Increase in humoral response Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement) Tumorigenic: Active as anti-cancer agent | FATOAO 55,46,1992 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
International Agency for Research on Cancer (IARC) Cancer Review | Animal Inadequate Evidence | IMEMDT 12,217,1976 |
International Agency for Research on Cancer (IARC) Cancer Review | Human No Adequate Data | IMEMDT 12,217,1976 |
International Agency for Research on Cancer (IARC) Cancer Review | Group 3 | IMSUDL 7,56,1987 |
TOXICOLOGY REVIEW |
| CNDQA8 10(3),43,1975 |
TOXICOLOGY REVIEW |
| CTOXAO 12,601,1978 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Occupational Exposure Limit - THE NETHERLANDS | MAC-TGG 2 mg/m3, 2003 |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Occupational Hazard Survey 1974 |
National Occupational Hazard Survey 1974: Hazard Code: 84765; Number of Industries 2; Total Number of Facilities 86; Number of Occupations 2; Total Number of Employees Exposed 732 | |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: 84765![]() Number of Industries 17; Total Number of Facilities 445; Number of Occupations 16; Total Number of Employees Exposed 7,970; Total Number of Female Employees Exposed 1,982 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat | |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
Used as a latex accelerator in the rubber-processing industry | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
On EPA IRIS database | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat | NCITR* NCI-TR-172,1979 |
REFERENCES: | |
CODEN |
REFERENCE |
ANDRDQ | Andrologia. (Grosse Verlag GmbH, Kurfuerstenstr. 112-113, D-1000 Berlin 30, Fed. Rep. Ger.) V.6- 1974- |
BBACAQ | Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1947- |
CBINA8 | Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- |
CNDQA8 | Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966- |
CTOXAO | Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. |
DRFUD4 | Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- |
EMMUEG | Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- |
FATOAO | Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- |
IMEMDT | IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- |
IMSUDL | IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- |
JTEHD6 | Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- |
MUREAV | Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- |
NCITR* | National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*. |
NTIS** | National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. |
NYKZAU | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- |
PCBPBS | Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971- |
PHARAT | Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- |
PHTOEH | Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987- |
WRPCA2 | World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued. |