The Registry of Toxic Effects of Chemical Substances

Calcium fluoride

RTECS #: EW1760000

CAS #: 7789-75-5

UPDATE: May 2004 MW: 78.08 MF: CaF2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Acid - spar
  2. Calcium difluoride
  3. Irtran 3
  1. Fluorspar
  2. Liparite
  3. Met - spar


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis rat
Ascites tumor 		1 gm/kg GANNA2 54,155,1963


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 3,200 mg/kg (9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) DZZEA7 34,124,1979
intraperitoneal
mouse 		lowest published toxic dose: 67,200 mg/kg (1-21 day pregnant) Reproductive: Other developmental abnormalities DZZEA7 34,484,1979


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mammal (species unspecified) 		lethal dose : >10 gm/kg N/R MTPEEI (7),32,1994
intraperitoneal
mouse 		lethal dose (50 percent kill): 2,638 mg/kg N/R DZZEA7 34,484,1979
intraperitoneal
rat 		lethal dose (50 percent kill): >1,500 mg/kg N/R XEURAQ UR-154,1951
oral
guinea pig 		lowest published lethal dose: >5 gm/kg N/R MEIEDD 11,253,1989
oral
rat 		lethal dose (50 percent kill): 4,250 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression 		VAMNAQ (2),28,1977
oral
rat 		lethal dose (50 percent kill): 4,417 mg/kg N/R VCVN5* -,354,1993


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 44 gm/kg/31 day- intermittent Cardiac: EKG changes not diagnostic of above

Musculoskeletal: Changes in teeth and supporting structures

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		MTPEEI (7),32,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2.5 mg(F)/m3 DTLVS* TLV/BEI,1999
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as a human carcinogen DTLVS* TLV/BEI,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 2.5 mg(F)/m3 DTLVS* 3,116,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 2.5 mg(F)/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 2.5 mg(F)/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 2.5 mg(F)/m3, JAN1993
Occupational Exposure Limit - FINLAND time-weighted average 2.5 mg(F)/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 2.5 mg(F)/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 2.5 mg(F)/m3, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 1 mg(F)/m3, short term exposure limit 2 mg(F)/m3, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 0.6 mg(F)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 2.5 mg(F)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg(HF)/m3, MAC(short term exposure limit) 3 mg(HF)/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 ppm (2.5 mg/m3), JAN1993
Occupational Exposure Limit - SWEDEN NGV 2 mg(F)/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 1.8 ppm (1.5 mg(F)/m3), KZG- week 3.6 ppm (3.0 mg(F)/m3), JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 2.5 mg(F)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2.5 mg(F)/m3, SEP2000
Occupational Exposure Limit - UNITED KINGDOM LTEL 2.5 mg(F)/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as a human carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as a human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FLUORIDES, INORGANIC-air 10 hour time-weighted average 2.5 mg(F)/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0579;
Number of Industries 17;
Total Number of Facilities 840;
Number of Occupations 22;
Total Number of Employees Exposed 17,561
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0579;
Number of Industries 187;
Total Number of Facilities 25,299;
Number of Occupations 76;
Total Number of Employees Exposed 344,071;
Total Number of Female Employees Exposed 3,195


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DZZEA7 Deutsche Zahnaerztliche Zeitschrift. (Carl Hanser Verlag, Postfach 860420, D-8000 Munich 86, Fed. Rep. Ger.) V.1- 1946-
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP.
MEIEDD Merck Index. (Merck & Co., Inc., Rahway, NJ 07065) 10th ed. 1983. For publisher information, see 85KYAH.
MTPEEI Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and Ecology. (Mezhdunarodnaya Kniga, ul.B. Yakimanka, 39 117049 Moscow, Russia) No.1- 1993-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
VAMNAQ Vestnik Akademii Meditsinskikh Nauk SSSR. Journal of the Academy of Medical Sciences of the USSR. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1946-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
XEURAQ U.S. Atomic Energy Commission, University of Rochester, Research and Development Reports. (Rochester, NY)

Used for production of HYDROFLUORIC ACID and as a flux in steel manufacture

NIOSH PROFILE (ALUMINUM REDUCTION PLANTS), FIRL, 4/78

RTECS Compound Description:
   Mutagen
   Reproductive Effector

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