The Registry of Toxic Effects of Chemical Substances

Butyronitrile

RTECS #: ET8750000

CAS #: 109-74-0

UPDATE: April 2002 MW: 69.12 MF: C4H7N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Butanenitrile
  2. n - Butanenitrile
  3. Butyric acid nitrile
  4. Butyrylonitrile
  1. 1 - Cyanopropane
  2. n - Butyronitrile
  3. Propyl cyanide
  4. Propylkyanid (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg/24 hour mild 85JCAE -,900,1986
skin
rabbit 		395 mg open irritation test mild UCDS** 5/17/1960


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 200 ppm/6 hour (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FAATDF 20,365,1993
oral
rat 		lowest published toxic dose: 500 mg/kg (10 day pregnant) Reproductive: Other effects to embryo or fetus TXAPA9 163,149,2000


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 249 ppm/1 hour Liver: Other changes CTOXAO 18,991,1981
inhalation
rat 		lowest published lethal concentration: 1,000 ppm/4 hour N/R AIHAAP 23,95,1962
intraperitoneal
mouse 		lethal dose (50 percent kill): 38 mg/kg Eye: Corneal damage

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		TXAPA9 59,589,1981
intraperitoneal
rat 		lethal dose (50 percent kill): 50 mg/kg Behavioral: Convulsions or effect on seizure threshold

Vascular: Regional or general arteriolar or venous dilation

Lung, Thorax, or Respiration: Dyspnea 		38MKAJ 2C,4873,1982
intravenous
rabbit 		lowest published lethal dose: 980 mg/kg N/R COREAF 153,895,1911
oral
cat 		lowest published lethal dose: 20 mg/kg N/R ZAARAM 19,225,1969
oral
mouse 		lethal dose (50 percent kill): 27,689 µg/kg N/R NEZAAQ 39,423,1984
oral
rat 		lethal dose (50 percent kill): 50 mg/kg Behavioral: Convulsions or effect on seizure threshold

Vascular: Regional or general arteriolar or venous dilation

Lung, Thorax, or Respiration: Dyspnea 		38MKAJ 2C,4873,1982
oral
rabbit 		lowest published lethal dose: 50 mg/kg N/R ZAARAM 19,225,1969
subcutaneous
frog 		lowest published lethal dose: 3,100 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea 		AIPTAK 5,161,1899
subcutaneous
guinea pig 		lowest published lethal dose: 100 mg/kg N/R COREAF 153,895,1911
subcutaneous
rabbit 		lowest published lethal dose: 10 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Respiratory stimulation 		AIPTAK 5,161,1899
skin
guinea pig 		lowest published lethal dose: 100 mg/kg N/R KODAK* 21MAY1971
skin
rabbit 		lethal dose (50 percent kill): 500 µL/kg N/R UCDS** 5/17/1960


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO N-BUTYRONITRILE-air 10 hour time-weighted average 8 ppm NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed. Rep. Ger.) V.1-25, 1951-75.

NIOSH PROFILE (NITRILES), SRC, 10/77

RTECS Compound Description:
   Reproductive Effector
   Primary Irritant

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