The Registry of Toxic Effects of Chemical Substances

Butyric acid

RTECS #: ES5425000

CAS #: 107-92-6

UPDATE: June 1998 MW: 88.12 MF: C4H8O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Butanic acid
  2. Butanoic acid
  3. Buttersaeure (German)
  4. n - Butyric acid
  1. Ethylacetic acid
  2. Kyselina maselna (Czech)
  3. 1 - Propanecarboxylic acid
  4. Propylformic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg open irritation test moderate UCDS** 4/10/1968
skin
rabbit 		20 mg/24 hour moderate 85JCAE -,306,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage chicken fibroblast 2 mmol/L CELLB5 12,855,1977
DNA damage human HeLa cell 3 mmol/L CELLB5 12,855,1977
DNA inhibition human lymphocyte 4 mmol/L HAONDL 2,381,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration : >500 mg/m3 Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi GISAAA 23(5),31,1958
inhalation
rat 		lethal concentration : >500 mg/m3 Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi TPKVAL 4,19,1962
intraperitoneal
mouse 		lethal dose (50 percent kill): 3,180 mg/kg N/R JPPMAB 21,85,1969
intravenous
mouse 		lethal dose (50 percent kill): 800 mg/kg Behavioral: Convulsions or effect on seizure threshold APTOA6 18,141,1961
oral
mouse 		lowest published lethal dose: 500 mg/kg Gastrointestinal: Necrotic changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen 		TPKVAL 4,19,1962
oral
rat 		lethal dose (50 percent kill): 2 gm/kg N/R 85GMAT -,30,1982
subcutaneous
mouse 		lethal dose (50 percent kill): 3,180 mg/kg N/R JPPMAB 21,85,1969
skin
rabbit 		lethal dose (50 percent kill): 530 µL/kg N/R UCDS** 4/10/1968


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
hamster 		lowest published toxic dose: 14 gm/kg/7 day- continuous Gastrointestinal: Other changes FCTOD7 29,367,1991
oral
mouse 		lowest published toxic dose: 33,600 mg/kg/7 day- continuous Gastrointestinal: Other changes FCTOD7 29,367,1991
oral
rat 		lowest published toxic dose: 14 gm/kg/7 day- continuous Gastrointestinal: Other changes FCTOD7 29,367,1991


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
AMIHAB 21,100,1960


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84458;
Number of Industries 6;
Total Number of Facilities 113;
Number of Occupations 12;
Total Number of Employees Exposed 1,747
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84458;
Number of Industries 7;
Total Number of Facilities 333;
Number of Occupations 27;
Total Number of Employees Exposed 11,600;
Total Number of Female Employees Exposed 3,391


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the manufacture of esters
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
CELLB5 Cell (Cambridge, Mass.). (MIT Press, 28 Carleton St., Cambridge, MA 02142) V.1- 1974-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HAONDL Hematological Oncology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W.Sussex, PO19 1UD, UK) V.1- 1983-
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used in the manufacture of esters

RTECS Compound Description:
   Mutagen
   Primary Irritant

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