The Registry of Toxic Effects of Chemical Substances

Butyraldehyde

RTECS #: ES2275000

CAS #: 123-72-8

UPDATE: February 2003 MW: 72.12 MF: C4H8O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Aldehyde butyrique (French)
  2. Aldeide butirrica (Italian)
  3. Butal
  4. Butaldehyde
  5. Butalyde
  6. Butanal
  7. n - Butanal (Czech)
  8. Butanaldehyde
  1. Butyl aldehyde
  2. n - Butyl aldehyde
  3. Butyral
  4. Butyraldehyd (German)
  5. Butyric aldehyde
  6. n - Butyraldehyde
  7. NCI - C56291


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		20 mg/24 hour moderate 85JCAE -,270,1986
skin
rabbit 		410 mg open irritation test mild UCDS** 7/20/1965


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage mammal (species unspecified) lymphocyte 100 mmol/L MUREAV 283,131,1992
unscheduled DNA synthesis rat liver 30 mmol/L MUREAV 323,121,1994
mutation in mammalian somatic cells hamster lung 3 mmol/L MUTAEX 4,277,1989
sister chromatid exchange hamster ovary 9 mg/L EMMUEG 10(Suppl 10),1,1987
sperm morphology intraperitoneal
mouse 		30 mg/kg MUREAV 39,317,1977
sperm morphology oral
mouse 		15 gm/kg/50 day MUREAV 39,317,1977


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published toxic concentration: 5,000 mg/m3 Gastrointestinal: Changes in structure or function of salivary glands VCVGK* -,373,1984
inhalation
human 		lowest published toxic concentration: 13 mg/m3 Eye: Conjunctiva irritation VCVGK* -,373,1984
inhalation
human 		lowest published toxic concentration: 0.75 mg/m3 Brain and Coverings: Other degenerative changes VCVGK* -,373,1984
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 38 gm/m3 N/R GISAAA 51(5),61,1986
inhalation
mouse 		lethal concentration (50 percent kill): 44,610 mg/m3/2 hour N/R 85GMAT -,30,1982
inhalation
mouse 		lethal concentration (50 percent kill): 36,000 mg/m3/2 hour Eye: Conjunctiva irritation

Behavioral: Ataxia

Lung, Thorax, or Respiration: Acute pulmonary edema 		VCVGK* -,373,1984
inhalation
rat 		lowest published lethal concentration: 8,000 ppm/4 hour N/R NTIS** OTS0516688
inhalation
rat 		lethal concentration (50 percent kill): 6,400 ppm/4 hour Eye: Conjunctiva irritation

Behavioral: Ataxia

Lung, Thorax, or Respiration: Acute pulmonary edema 		VCVGK* -,373,1984
inhalation
rat 		lowest published toxic concentration: 600 ppm/10 minute Lung, Thorax, or Respiration: Respiratory depression VCVGK* -,373,1984
inhalation
rabbit 		lowest published toxic concentration: 200 mg/m3/40 minute Lung, Thorax, or Respiration: Dyspnea VCVGK* -,373,1984
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,140 mg/kg N/R FCTXAV 17,731,1979
intraperitoneal
rat 		lethal dose (50 percent kill): 800 mg/kg N/R FCTXAV 17,731,1979
oral
rat 		lethal dose (50 percent kill): 2,490 mg/kg N/R NTIS** OTS0516688
oral
rat 		lethal dose (50 percent kill): 5,890 mg/kg Eye: Conjunctiva irritation

Behavioral: Ataxia

Lung, Thorax, or Respiration: Acute pulmonary edema 		VCVGK* -,373,1984
subcutaneous
mouse 		lethal dose (50 percent kill): 2,700 mg/kg Behavioral: General anesthetic

Kidney, Ureter, and Bladder: Hematuria 		APTOA6 6,299,1950
subcutaneous
rat 		lethal dose (50 percent kill): 10 gm/kg Behavioral: General anesthetic APTOA6 6,299,1950
skin
rabbit 		lethal dose (50 percent kill): 3,560 µL/kg N/R UCDS** 7/20/1965


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 3,100 ppm/6 hour/2 week- intermittent Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands 		NTIS** OTS0570659
inhalation
dog 		lowest published toxic concentration: 2,000 ppm/6 hour/14 week- intermittent Olfaction: Other olfaction effects NTIS** OTS0538653
inhalation
guinea pig 		lowest published toxic concentration: 3,100 ppm/6 hour/2 week- intermittent Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0570659
inhalation
mouse 		lowest published toxic concentration: 6,400 ppm/6 hour/2 week- intermittent Eye: Other eye effects

Lung, Thorax, or Respiration: Dyspnea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0570659
inhalation
rat 		lowest published toxic concentration: 3,100 ppm/6 hour/2 week- intermittent Lung, Thorax, or Respiration: Dyspnea

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0570659
inhalation
rat 		lowest published toxic concentration: 125 ppm/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		NTIS** OTS0538653
inhalation
rat 		lowest published toxic concentration: 125 ppm/6 hour/13 week- intermittent Olfaction: Other olfaction effects VCVGK* -,373,1994
inhalation
rat 		lowest published toxic concentration: 50 mg/m3/110 day- intermittent Lung, Thorax, or Respiration: Emphysema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,373,1994
inhalation
rat 		lowest published toxic concentration: 0.5 mg/m3/120 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		VCVGK* -,373,1994
inhalation
rabbit 		lowest published toxic concentration: 3,100 ppm/6 hour/2 week- intermittent Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands 		NTIS** OTS0570659
inhalation
rabbit 		lowest published toxic concentration: 50 mg/m3/110 day- intermittent Lung, Thorax, or Respiration: Emphysema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,373,1994
oral
mouse 		lowest published toxic dose: 78 gm/kg/90 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0516688
oral
mouse 		lowest published toxic dose: 15,000 mg/kg/12 day- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Gastrointestinal: Ulceration or bleeding from stomach 		VCVGK* -,373,1994
oral
rat 		lowest published toxic dose: 39 gm/kg/90 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0516688
oral
rat 		lowest published toxic dose: 15,000 mg/kg/12 day- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Gastrointestinal: Ulceration or bleeding from stomach 		VCVGK* -,373,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
EVHPAZ 11,163,1975


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, Skin, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0281;
Number of Industries 3;
Total Number of Facilities 91;
Number of Occupations 9;
Total Number of Employees Exposed 1,258
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0281;
Number of Industries 2;
Total Number of Facilities 38;
Number of Occupations 6;
Total Number of Employees Exposed 5,392;
Total Number of Female Employees Exposed 950


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used to make intermediates for plasticizers, coatings, dyes and insecticides
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN #55, September 1991
NIOSH Analytical Method, 1994: Aldehydes, screening, 2539


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used to make intermediates for plasticizers, coatings, dyes and insecticides

NIOSH PROFILE (ALDEHYDES), SRC, 4/78

NIOSH PROFILE (ALDEHYDES), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Human Data
   Primary Irritant

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