The Registry of Toxic Effects of Chemical Substances

tert - Butyl peroxide

RTECS #: ER2450000

CAS #: 110-05-4

UPDATE: February 2004 MW: 146.26 MF: C8H18O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Bis (t - butyl) peroxide
  2. Bis (1,1 - dimethylethyl) peroxide
  3. Cadox TBP
  4. Interox DTB
  5. Di - tert - butylperoxid (German)
  6. Di - tert - butyl peroxide
  7. Di - tert - butyl peroxyde (Dutch)
  8. DTBP
  1. Kayabutyl D
  2. Perbutyl D
  3. Perossido di butile terziario (Italian)
  4. Peroxide, bis (1,1 - dimethylethyl)
  5. Peroxyde de butyle tertiaire (French)
  6. (Tributyl) peroxide
  7. Trigonox B


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg/24 hour mild 85JCAE -,263,1986
eye
rabbit 		200 mg/1 minute rinse mild ZAARAM 8,25,1958
skin
rabbit 		500 mg mild AIHAAP 19,205,1958


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 226 mg/m3/4 hour (1-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) GTPZAB 20(12),46,1976


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
unreported route
mouse 		lowest published toxic dose: 585 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Lymphoma including Hodgkin's disease 		RARSAM 3,193,1963


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): >4,103 ppm/4 hour Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea 		AIHAAP 19,205,1958
inhalation
rat 		lethal concentration (50 percent kill): >4,100 ppm/4 hour N/R ARCOC* JUN1982
intraperitoneal
mouse 		lethal dose (50 percent kill): 4,572 mg/kg N/R VCVGK* -,526,1994
intraperitoneal
rat 		lethal dose (50 percent kill): 3,210 mg/kg Behavioral: Muscle weakness

Behavioral: Ataxia 		AIHAAP 19,205,1958
oral
mouse 		lethal dose (50 percent kill): 216.4 mg/kg N/R VCVGK* -,526,1994
oral
rat 		lethal dose (50 percent kill): >25 gm/kg N/R ARCOC* JUN1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 105 gm/kg/7 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AIHAAP 19,205,1958


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - GERMANY Weak skin effects, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 100 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0478;
Number of Industries 3;
Total Number of Facilities 100;
Number of Occupations 5;
Total Number of Employees Exposed 872
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0478;
Number of Industries 26;
Total Number of Facilities 1,178;
Number of Occupations 30;
Total Number of Employees Exposed 20,561;
Total Number of Female Employees Exposed 6,371


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as polymerization initiator, curing agent and cross-linking agent
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ARCOC* ARCO Chemical Company Report. (3801 West Chester Pike, Newton Square, PA 19073)
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
RARSAM Radiation Research, Supplement. (New York, NY) No.1-7, 1959-67. Discontinued.
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed. Rep. Ger.) V.1-25, 1951-75.

Used as polymerization initiator, curing agent and cross-linking agent

NIOSH PROFILE (PEROXIDES, ORGANIC), SRC, 12/79

RTECS Compound Description:
   Tumorigen
   Reproductive Effector
   Primary Irritant

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