The Registry of Toxic Effects of Chemical Substances

Butylamine

RTECS #: EO2975000

CAS #: 109-73-9

UPDATE: November 2004 MW: 73.16 MF: C4H11N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1 - Amino - butaan (Dutch)
  2. 1 - Aminobutan (German)
  3. 1 - Aminobutane
  4. 1 - Butanamine
  5. Butylamine (OSHA)
  6. Mono - n - butylamine
  7. Monobutilamina (Romanian)
  1. Monobutylamine
  2. Norvalamine
  3. n - Butilamina (Italian)
  4. n - Butylamin (German)
  5. n - Butylamine
  6. n - Butylamine (ACGIH)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		250 µg/24 hour severe 85JCAE -,431,1986
skin
rabbit 		10 mg/24 hour open irritation test severe JIHTAB 26,269,1944
skin
rabbit 		500 mg open irritation test severe UCDS** 7/19/1965


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis oral
rat 		110 mg/kg ZKKOBW 86,47,1976


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 2.4 gm/kg (1-6 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Other developmental abnormalities 		FCTOD7 40,1833,2002
oral
rat 		lowest published toxic dose: 6 gm/kg (1-6 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system 		FCTOD7 40,1833,2002


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 800 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors 		BCPCA6 2,168,1959


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 800 mg/m3/2 hour N/R 85GMAT -,28,1982
inhalation
rat 		lowest published lethal concentration: 4,000 ppm/4 hour N/R JIHTAB 31,343,1949
intraperitoneal
mouse 		lethal dose (50 percent kill): 629 mg/kg N/R JPETAB 88,82,1946
intravenous
mouse 		lethal dose (50 percent kill): 198 mg/kg N/R JPETAB 88,82,1946
oral
guinea pig 		lethal dose (50 percent kill): 430 mg/kg N/R GISAAA 40(11),21,1975
oral
mouse 		lethal dose (50 percent kill): 430 mg/kg N/R GISAAA 40(11),21,1975
oral
rat 		lethal dose (50 percent kill): 366 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression 		TXAPA9 63,150,1982
parenteral
rat 		lowest published lethal dose: 600 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Lung, Thorax, or Respiration: Dyspnea 		JPETAB 20,435,1923
skin
guinea pig 		lethal dose (50 percent kill): 500 µL/kg N/R JIHTAB 26,269,1944
skin
rabbit 		lethal dose (50 percent kill): 850 µL/kg N/R UCDS** 7/19/1965
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 590 mg/kg N/R TPKVAL 14,80,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 17 ppm/6 hour/14 day- intermittent Olfaction: Other olfaction effects FCTOD7 40,1833,2002
intramuscular
rat 		lowest published toxic dose: 6 gm/kg/6 day- intermittent Behavioral: Food intake (animal) FCTOD7 40,1833,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 5 ppm (skin) DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
CHREAY 9,389,1931


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD air-ceiling concentration 5 ppm (15 mg/m3) (skin) DTLVS* 3,32,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 5 ppm (15 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 5 ppm (15 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 5 ppm (15 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 5 ppm (15 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (15 mg/m3), Skin, JAN1999
Occupational Exposure Limit - AUSTRIA MAK 5 ppm (15 mg/m3), Skin, JAN1993
Occupational Exposure Limit - BELGIUM short term exposure limit 5 ppm (15 mg/m3), Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (15 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND short term exposure limit 5 ppm (15 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VLE 5 ppm (15 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 5 ppm (15 mg/m3), Skin, JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit( continuous) 5 ppm (15 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC- continuous 15 mg/m3, Skin, 2003
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (15 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 ppm (15 mg/m3), Skin, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 5 ppm (10 mg/m3), Skin, JAN1993
Occupational Exposure Limit - SWEDEN CEILING 5 ppm (15 mg/m3), Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (15 mg/m3), short term exposure limit 25 ppm (75 mg/m3), Skin, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 5 ppm (15 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 5 ppm (15 mg/m3), Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 5 ppm (15 mg/m3), Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

ceiling concentration 5 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
ceiling concentration 5 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BUTYLAMINE-air ceiling concentration 5 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 14440;
Number of Industries 4;
Total Number of Facilities 97;
Number of Occupations 9;
Total Number of Employees Exposed 1,168
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 14440;
Number of Industries 2;
Total Number of Facilities 20;
Number of Occupations 1;
Total Number of Employees Exposed 414;
Total Number of Female Employees Exposed 85


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: n-Butylamine, 2012


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin, Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7.

NIOSH PROFILE (AMINES, PRIMARY ALIPHATIC), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

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