The Registry of Toxic Effects of Chemical Substances

sec - Butyl alcohol

RTECS #: EO1750000

CAS #: 78-92-2

UPDATE: November 2004 MW: 74.14 MF: C4H10O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. (+ - ) - 2 - Butanol
  2. 1 - Methyl propanol
  3. 1 - Methyl - 1 - propanol
  4. 1 - Methylpropyl alcohol
  5. 2 - Butanol
  6. 2 - Butyl alcohol
  7. 2 - Hydroxybutane
  8. Alcool butylique secondaire (French)
  9. Butan - 2 - ol
  10. Butanol secondaire (French)
  11. Butanol - 2
  12. Butylene hydrate
  1. CCS 301
  2. DL - Butan - 2 - ol
  3. Ethylmethyl carbinol
  4. Methylethylcarbinol
  5. Racemic - 2 - butanol
  6. S.B.A.
  7. dl - Methylethylcarbinol
  8. s - Butanol
  9. s - Butyl alcohol
  10. sec - Butanol
  11. sec - Butanol (ACGIH)
  12. sec - Butyl alcohol (OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 5,000 ppm/7 hour (1-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FAATDF 12,469,1989
inhalation
rat 		lowest published toxic concentration: 7,000 ppm/7 hour (1-19 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		FAATDF 12,469,1989


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 16,000 ppm/4 hour Olfaction: Other olfaction effects

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes 		SHELL* MSDS-5280-4
inhalation
rat 		lethal concentration (50 percent kill): 48,500 mg/m3/4 hour N/R VCVGK* -,102,1984
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 1,067 mg/kg N/R EVHPAZ 61,321,1985
intraperitoneal
hamster 		lethal dose (50 percent kill): 1,218 mg/kg N/R EVHPAZ 61,321,1985
intraperitoneal
mouse 		lethal dose (50 percent kill): 771 mg/kg N/R SCCUR* -,2,1961
intraperitoneal
rat 		lethal dose (50 percent kill): 1,193 mg/kg N/R EVHPAZ 61,321,1985
intraperitoneal
rabbit 		lethal dose (50 percent kill): 277 mg/kg N/R EVHPAZ 61,321,1985
intravenous
mouse 		lethal dose (50 percent kill): 764 mg/kg N/R AIPTAK 135,330,1962
intravenous
rat 		lethal dose (50 percent kill): 138 mg/kg N/R EVHPAZ 61,321,1985
oral
dog 		lowest published lethal dose: 2,400 mg/kg N/R NTIS** OTS0572377
oral
rat 		lethal dose (50 percent kill): 2,193 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Behavioral: Coma 		NTIS** OTS0557575
oral
rat 		lethal dose (50 percent kill): 6,200 mg/kg N/R VCVGK* -,102,1984
oral
rabbit 		lethal dose (50 percent kill): 4,893 mg/kg Eye: Corneal damage

Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Dyspnea 		IMSUAI 41,31,1972
oral
rabbit 		lethal dose (50 percent kill): 4,900 mg/kg N/R VCVGK* -,102,1984
oral
rabbit 		lowest published lethal dose: 3,000 mg/kg N/R VCVGK* -,102,1984
parenteral
frog 		lowest published lethal dose: 15 gm/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity) 		AIPTAK 50,296,1935
skin
rat 		lethal dose (50 percent kill): >2 gm/kg N/R NTIS** OTS0557575


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 500 ppm/6 hour/5 day- intermittent Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		ATSUDG 8,418,1985


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 100 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 150 ppm (450 mg/m3) DTLVS* 3,32,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 150 ppm (450 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 150 ppm (450 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 150 ppm (450 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 150 ppm (450 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 100 ppm (305 mg/m3), short term exposure limit 150 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 50 ppm (150 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 100 ppm (303 mg/m3), short term exposure limit 150 ppm (455 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (150 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 100 ppm (300 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 100 ppm (300 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 100 ppm (300 mg/m3), JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 100 ppm (300 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 450 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (75 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 150 ppm (450 mg/m3), JAN1993
Occupational Exposure Limit - POLAND time-weighted average 300 mg/m3, short term exposure limit 450 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 100 ppm, short term exposure limit 10 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 50 ppm (150 mg/m3), short term exposure limit 75 ppm (250 mg/m3), Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 100 ppm (300 mg/m3), KZG- week 200 ppm (600 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 150 ppm (450 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 100 99m (308 mg/m3), short term exposure limit 150 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 100 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 100 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO sec-BUTYL ALCOHOL-air 10 hour time-weighted average 100 ppm;
short term exposure limit 150 ppm 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 14410;
Number of Industries 59;
Total Number of Facilities 2,929;
Number of Occupations 47;
Total Number of Employees Exposed 42,853
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 14410;
Number of Industries 97;
Total Number of Facilities 5,896;
Number of Occupations 72;
Total Number of Employees Exposed 126,196;
Total Number of Female Employees Exposed 36,723


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in a variety of coating applications as an active and latent solvent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols II, 1401


REFERENCES:

CODEN
REFERENCE
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
SHELL* Shell Chemical Company. (P.O. Box 4320, Houston, TX 77210)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used in a variety of coating applications as an active and latent solvent

RTECS Compound Description:
   Reproductive Effector

ALT CAS #: 15892-23-6
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