The Registry of Toxic Effects of Chemical Substances

3 - Buten - 2 - one

RTECS #: EM9800000

CAS #: 78-94-4

UPDATE: May 2004 MW: 70.10 MF: C4H6O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 3 - Butene - 2 - one
  2. Acetone, methylene -
  3. Acetyl ethylene
  4. Butenone
  5. Ketone, methyl vinyl
  6. MVK
  7. Methyl vinyl ketone
  1. Methyl - vinyl - cetone (French)
  2. Methylene acetone
  3. Methylvinyl ketone
  4. Methylvinylketon (German)
  5. Vinyl methyl ketone
  6. delta (sup 3) - 2 - Butenone
  7. gamma - Oxo - alpha - butylene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		1% severe VCVGK* -,434,1994
skin
mouse 		0.1% mild VCVGK* -,434,1994
skin
rat 		1% severe VCVGK* -,434,1994
skin
rat 		0.1% mild VCVGK* -,434,1994


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Escherichia coli 125 µg/plate (+enzymatic activation step) MUREAV 412,17,1998
mutation in microorganisms Salmonella typhimurium 250 µmol/L (+enzymatic activation step) MUREAV 93,305,1982
other mutation test systems Escherichia coli 100 nmol/tube CRTOEC 4,50,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 8 mg/m3/2 hour N/R 85GMAT -,88,1982
inhalation
mouse 		lethal concentration (50 percent kill): 16 mg/m3 Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Emphysema

Liver: Other changes 		VCVGK* -,433,1994
inhalation
rat 		lethal concentration (50 percent kill): 7 mg/m3/4 hour N/R 85GMAT -,88,1982
inhalation
rat 		lethal concentration (50 percent kill): 14 mg/m3 Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Emphysema

Liver: Other changes 		VCVGK* -,433,1994
intraperitoneal
guinea pig 		lowest published lethal dose: 15 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		NTIS** OTS0555304
intraperitoneal
mouse 		lethal dose (50 percent kill): 76 mg/kg N/R ZolH## 23OCT1975
intraperitoneal
rat 		lowest published lethal dose: 15 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia 		NTIS** OTS0555304
oral
guinea pig 		lowest published lethal dose: 15 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression 		NTIS** OTS0555304
oral
mouse 		lethal dose (50 percent kill): 23,300 µg/kg N/R GISAAA 58(10),4,1993
oral
mouse 		lethal dose (50 percent kill): 33.5 mg/kg Gastrointestinal: Necrotic changes VCVGK* -,433,1994
oral
rat 		lethal dose (50 percent kill): 23,100 µg/kg N/R GISAAA 58(10),4,1993
oral
rat 		lethal dose (50 percent kill): 31 mg/kg Gastrointestinal: Necrotic changes VCVGK* -,433,1994
skin
mouse 		lowest published lethal dose: 10 pph/4 hour N/R VCVGK* -,434,1994
skin
mouse 		lowest published lethal dose: 100 pph/1 hour N/R VCVGK* -,434,1994
skin
rat 		lowest published lethal dose: 10 pph/4 hour N/R VCVGK* -,434,1994
skin
rat 		lowest published lethal dose: 100 pph/1 hour N/R VCVGK* -,434,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 7,800 ppb/6 hour/9 day- intermittent Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0555304
inhalation
mouse 		lowest published toxic concentration: 4 ppm/24 hour/ intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOSCF2 58,182,2000
inhalation
mouse 		lowest published toxic concentration: 8 ppm/72 hour/ intermittent Lung, Thorax, or Respiration: Other changes TOSCF2 58,182,2000
inhalation
mouse 		lowest published toxic concentration: 8 ppm/60 hour/ intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TOSCF2 58,182,2000
inhalation
mouse 		lowest published toxic concentration: 2 ppm/72 hour/ intermittent Olfaction: Other olfaction effects TOSCF2 58,182,2000
inhalation
rat 		lowest published toxic concentration: 3,900 ppb/6 hour/9 day- intermittent Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Acute pulmonary edema

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0555304
inhalation
rat 		lowest published toxic concentration: 2 ppm/24 hour/ intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOSCF2 58,182,2000
inhalation
rat 		lowest published toxic concentration: 2 ppm/72 hour/ intermittent Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOSCF2 58,182,2000
inhalation
rat 		lowest published toxic concentration: 2 ppm/72 hour/ intermittent Olfaction: Other olfaction effects TOSCF2 58,182,2000
inhalation
rat 		lowest published toxic concentration: 4 ppm/72 hour/ intermittent Lung, Thorax, or Respiration: Other changes TOSCF2 58,182,2000
inhalation
rat 		lowest published toxic concentration: 2 ppm/390 hour/ intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight 		TOSCF2 58,182,2000
inhalation
rat 		lowest published toxic concentration: 1.8 mg/m3/6 hour/137 day- intermittent Behavioral: Somnolence (general depressed activity)

Liver: Liver function tests impaired 		VCVGK* -,434,1994
inhalation
rat 		lowest published toxic concentration: 0.9 mg/m3/6 hour/137 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain VCVGK* -,434,1994
inhalation
rabbit 		lowest published toxic concentration: 7,800 ppb/6 hour/9 day- intermittent Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Respiratory depression 		NTIS** OTS0555304
inhalation
rabbit 		lowest published toxic concentration: 4 mg/m3/4 hour/75 day- intermittent Liver: Multiple effects

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGK* -,434,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 0.2 ppm (skin, sen) DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - GERMANY No MAK Established, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, Skin, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an alkylating agent and as an intermediate in the synthesis of steroids and vitamin A
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
CRTOEC Chemical Research in Toxicology. (American Chemical Soc., Distribution Office Dept. 223, POB 57/36, West End Station, Washington, DC 20037) V.1- 1988-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
ZolH## Personal Communication from H. Zollner, Institut fur Biochemie, Der Universitat, Gras, Oct. 23, 1975

Used as an alkylating agent and as an intermediate in the synthesis of steroids and vitamin A

RTECS Compound Description:
   Mutagen
   Primary Irritant

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