The Registry of Toxic Effects of Chemical Substances

1 - Butene, 2,3,4 - trichloro -

RTECS #: EM9046000

CAS #: 2431-50-7

UPDATE: February 2004 MW: 159.44 MF: C4H5Cl3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 2,3,4 - Trichlorobutene - 1


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 2 ppm/6 hour/85 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors 		NTIS** OTS0555038


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 100 mg/m3 N/R VCVGH* -,492,1990
inhalation
rat 		lethal concentration (50 percent kill): 625 mg/m3 N/R VCVGH* -,492,1990
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 345 mg/kg N/R VCVGH* -,492,1990
oral
rat 		lethal dose (50 percent kill): 341 mg/kg N/R GISAAA 46(1),92,1981


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 2,500 ppb/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Changes in lung weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		NTIS** OTS0546198
inhalation
rat 		lowest published toxic concentration: 2,500 ppb/6 hour/13 week- intermittent Behavioral: Excitement

Liver: Liver function tests impaired

Blood: Changes in erythrocyte (RBC) count 		NTIS** OTS0546540


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

RTECS Compound Description:
   Tumorigen

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