The Registry of Toxic Effects of Chemical Substances

2 - Butanone, peroxide

RTECS #: EL9450000

CAS #: 1338-23-4

UPDATE: November 2004 MW: 176.24 MF: C8H16O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Butanox LPT
  2. Butanox M 105
  3. Butanox M 50
  4. Chaloxyd MEKP - HA 1
  5. Chaloxyd MEKP - LA 1
  6. Esperfoam FR
  7. Ethyl methyl ketone peroxide
  8. FR 222
  9. HI - Point 180
  10. HI - Point 90
  11. HI - Point PD - 1
  12. Kayamek A
  13. Kayamek M
  14. Ketonox
  15. Lucidol DDM 9
  16. Lucidol Delta X
  17. Lupersol DDA 30
  18. Lupersol DDM
  19. Lupersol DNF
  1. Lupersol DSW
  2. Lupersol Delta X
  3. MEK peroxide
  4. MEKPO
  5. Mepox
  6. Methyl ethyl ketone hydroperoxide
  7. Methyl ethyl ketone peroxide
  8. Methyl ethyl ketone peroxide (ACGIH)
  9. Methylethylketonhydroperoxide
  10. NCI - C55447
  11. Permek G
  12. Permek N
  13. Quickset Extra
  14. Quickset super
  15. RCRA waste number U160
  16. Sprayset MEKP
  17. Superox 46 - 710
  18. Thermacure


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		3 mg N/R AIHAAP 19,205,1958
eye
rabbit 		40 % VCVGK* -,529,1994
skin
rabbit 		500 mg % AIHAAP 19,205,1958


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
unreported route
mouse 		lowest published toxic dose: 282 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Lymphoma including Hodgkin's disease 		RARSAM 3,193,1963


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 170 ppm/4 hour Lung, Thorax, or Respiration: Dyspnea AIHAAP 19,205,1958
inhalation
mouse 		lethal concentration (50 percent kill): 2,500 mg/m3/4 hour Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough 		VCVGK* -,528,1994
inhalation
rat 		lethal concentration (50 percent kill): 200 ppm/4 hour Lung, Thorax, or Respiration: Dyspnea AIHAAP 19,205,1958
inhalation
rat 		lethal concentration (50 percent kill): 3,600 mg/m3/4 hour Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough 		VCVGK* -,528,1994
intraperitoneal
mouse 		lethal dose (50 percent kill): 200 mg/kg N/R VCVGK* -,528,1994
intraperitoneal
rat 		lethal dose (50 percent kill): 65 mg/kg Behavioral: Muscle weakness

Behavioral: Ataxia 		AIHAAP 19,205,1958
intraperitoneal
rat 		lowest published toxic dose: 90 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) 		VCVGK* -,528,1994
oral
human 		lowest published toxic dose: 480 mg/kg Gastrointestinal: Changes in structure or function of esophagus

Gastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes 		NCPBBY Jan/Feb,1969
oral
mouse 		lethal dose (50 percent kill): 250 mg/kg N/R VCVGK* -,528,1994
oral
rat 		lethal dose (50 percent kill): 470 mg/kg N/R VCVGK* -,528,1994
skin
rabbit 		lowest published toxic dose: 2,000 mg/kg Skin: After topical application: Primary irritation VCVGK* -,528,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 273 mg/kg/7 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AIHAAP 19,205,1958
oral
rat 		lowest published toxic dose: 2,033 mg/kg/7 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AIHAAP 19,205,1958


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 0.2 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.2 ppm (1.5 mg/m3), JAN1993
Occupational Exposure Limit - BELGIUM short term exposure limit 0.2 ppm (1.5 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 1 mg/m3, JAN1999
Occupational Exposure Limit - FINLAND short term exposure limit 0.2 ppm (1.5 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VLE 0.2 ppm (1.5 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY Produces severe skin effects, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 1 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC- continuous 1.5 mg/m3, 2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.2 ppm (1.5 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 0.2 ppm (1.5 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

ceiling concentration 0.2 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
ceiling concentration 0.2 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL ETHYL KETONE PEROXIDE-air ceiling concentration 0.2 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80105;
Number of Industries 29;
Total Number of Facilities 2,226;
Number of Occupations 31;
Total Number of Employees Exposed 20,053
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80105;
Number of Industries 23;
Total Number of Facilities 1,879;
Number of Occupations 31;
Total Number of Employees Exposed 25,827;
Total Number of Female Employees Exposed 6,514


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as polymerization catalyst, curing agent and cross-linking agent
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Methyl ethyl ketone peroxide, 3508
NTP Toxicity studies, RPT# TOX-18, October 2000
OSHA ANALYTICAL METHOD #77


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
NCPBBY National Clearinghouse for Poison Control Centers, Bulletin. (U.S. Department of Health, Education, and Welfare, Washington, DC)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RARSAM Radiation Research, Supplement. (New York, NY) No.1-7, 1959-67. Discontinued.
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as polymerization catalyst, curing agent and cross-linking agent

NIOSH PROFILE (METHYL ETHYL KETONE PEROXIDE), SRC, 10/77

NIOSH PROFILE (PEROXIDES, ORGANIC), SRC, 12/79

RTECS Compound Description:
   Tumorigen
   Human Data
   Primary Irritant

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