RTECS:EL9100000 The Registry of Toxic Effects of Chemical Substances

The Registry of Toxic Effects of Chemical Substances

2 - Butanone, 3 - methyl -

RTECS #: EL9100000

CAS #: 563-80-4

UPDATE: November 2004 MW: 86.15 MF: C₅H₁₀O

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

SKIN AND EYE IRRITATION DATA:

MUTATION DATA:

ACUTE TOXICITY DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

2 - Acetyl propane

3 - Methyl - 2 - butanone

3 - Methylbutanone

Isopropyl methyl ketone

MIPK

Methyl isopropyl ketone

Methyl isopropyl ketone (ACGIH)

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
eye
rabbit 100 mg/24 hour mild FCTXAV 16,819,1978
eye
rabbit 500 mg/24 hour mild 85JCAE -,282,1986
skin
rabbit 500 mg/24 hour moderate FCTXAV 16,819,1978
skin
rabbit 500 mg open irritation test mild FCTXAV 16,637,1978

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
gene conversion and mitotic recombination Saccharomyes cerevisiae 12,300 ppm MUREAV 149,339,1985

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
mouse lethal concentration (50 percent kill): 30,000 mg/m³ Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes VCVGK* -,422,1994
inhalation
rat lowest published lethal concentration: 5,700 ppm/4 hour N/R TXAPA9 28,313,1974
intraperitoneal
mouse lethal dose (50 percent kill): 200 mg/kg N/R 38MKAJ 2C,4737,1982
intraperitoneal
rat lethal dose (50 percent kill): 800 mg/kg N/R 38MKAJ 2C,4737,1982
oral
mouse lethal dose (50 percent kill): 2,572 mg/kg N/R TOLED5 30,13,1986
oral
mouse lethal dose (50 percent kill): 3,000 mg/kg Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes VCVGK* -,422,1994
oral
rat lethal dose (50 percent kill): 3,078 mg/kg N/R ACMIK* 1988
oral
rat lethal dose (50 percent kill): 3,000 mg/kg Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes VCVGK* -,422,1994
skin
rabbit lethal dose (50 percent kill): 6,350 mg/kg N/R FCTXAV 16,819,1978

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 ppm DTLVS* TLV/BEI,2003

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 200 ppm (705 mg/m³), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 200 ppm (705 mg/m³), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 200 ppm (705 mg/m³), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 200 ppm (700 mg/m³), short term exposure limit 250 ppm (875 mg/m³), JAN1999
Occupational Exposure Limit - FRANCE VME 200 ppm (705 mg/m³), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 100 ppm (350 mg/m³), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 200 ppm (720 mg/m³), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 705 mg/m³, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 200 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 200 ppm

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL ISOPROPYL KETONE-air 10 hour time-weighted average 200 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83768;
Number of Industries 3;
Total Number of Facilities 68;
Number of Occupations 7;
Total Number of Employees Exposed 1,055

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a slovent for NITROCELLULOSE lacquers
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN
REFERENCE

38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ACMIK* Acute toxicity of methyl isopropyl ketone, Toxicological Sciences Laboratory, Health and Environment Laboratories, Eastman Kodak Company, Rochester, NY; HAEL No. 88-0008, May 19, 1988.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a slovent for NITROCELLULOSE lacquers

RTECS Compound Description:
Mutagen
Primary Irritant

Click Here for Additional Information about RTECS

SYNONYMS:
2 - Acetyl propane 3 - Methyl - 2 - butanone 3 - Methylbutanone Isopropyl methyl ketone	MIPK Methyl isopropyl ketone Methyl isopropyl ketone (ACGIH)

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
eye rabbit	100 mg/24 hour	mild	FCTXAV 16,819,1978
eye rabbit	500 mg/24 hour	mild	85JCAE -,282,1986
skin rabbit	500 mg/24 hour	moderate	FCTXAV 16,819,1978
skin rabbit	500 mg open irritation test	mild	FCTXAV 16,637,1978

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
gene conversion and mitotic recombination	Saccharomyes cerevisiae	12,300 ppm	MUREAV 149,339,1985

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation mouse	lethal concentration (50 percent kill): 30,000 mg/m³	Lung, Thorax, or Respiration: Other changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVGK* -,422,1994
inhalation rat	lowest published lethal concentration: 5,700 ppm/4 hour	N/R	TXAPA9 28,313,1974
intraperitoneal mouse	lethal dose (50 percent kill): 200 mg/kg	N/R	38MKAJ 2C,4737,1982
intraperitoneal rat	lethal dose (50 percent kill): 800 mg/kg	N/R	38MKAJ 2C,4737,1982
oral mouse	lethal dose (50 percent kill): 2,572 mg/kg	N/R	TOLED5 30,13,1986
oral mouse	lethal dose (50 percent kill): 3,000 mg/kg	Lung, Thorax, or Respiration: Other changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVGK* -,422,1994
oral rat	lethal dose (50 percent kill): 3,078 mg/kg	N/R	ACMIK* 1988
oral rat	lethal dose (50 percent kill): 3,000 mg/kg	Lung, Thorax, or Respiration: Other changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVGK* -,422,1994
skin rabbit	lethal dose (50 percent kill): 6,350 mg/kg	N/R	FCTXAV 16,819,1978

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value	time-weighted average 200 ppm	DTLVS* TLV/BEI,2003

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Occupational Exposure Limit - AUSTRALIA	time-weighted average 200 ppm (705 mg/m³), JAN1993
Occupational Exposure Limit - BELGIUM	time-weighted average 200 ppm (705 mg/m³), JAN1993
Occupational Exposure Limit - DENMARK	time-weighted average 200 ppm (705 mg/m³), JAN1999
Occupational Exposure Limit - FINLAND	time-weighted average 200 ppm (700 mg/m³), short term exposure limit 250 ppm (875 mg/m³), JAN1999
Occupational Exposure Limit - FRANCE	VME 200 ppm (705 mg/m³), JAN1999
Occupational Exposure Limit - NORWAY	time-weighted average 100 ppm (350 mg/m³), JAN1999
Occupational Exposure Limit - SWITZERLAND	MAK- week 200 ppm (720 mg/m³), JAN1999
Occupational Exposure Limit - THE NETHERLANDS	MAC-TGG 705 mg/m³, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA	American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; time-weighted average 200 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM	American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 ppm

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL ISOPROPYL KETONE-air	10 hour time-weighted average 200 ppm	NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 83768; Number of Industries 3; Total Number of Facilities 68; Number of Occupations 7; Total Number of Employees Exposed 1,055

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a slovent for NITROCELLULOSE lacquers
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN	REFERENCE
38MKAJ	"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
85JCAE	"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ACMIK*	Acute toxicity of methyl isopropyl ketone, Toxicological Sciences Laboratory, Health and Environment Laboratories, Eastman Kodak Company, Rochester, NY; HAEL No. 88-0008, May 19, 1988.
DTLVS*	The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTXAV	Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH*	National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TOLED5	Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9	Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK*	"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.