RTECS:EL5425000 The Registry of Toxic Effects of Chemical Substances

The Registry of Toxic Effects of Chemical Substances

1 - Butanol, 3 - methyl -

RTECS #: EL5425000

CAS #: 123-51-3

UPDATE: November 2004 MW: 88.17 MF: C₅H₁₂O

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

SKIN AND EYE IRRITATION DATA:

TUMORIGENIC DATA:

ACUTE TOXICITY DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

2 - Methyl - 4 - butanol

3 - Methyl butanol

3 - Methyl - 1 - butanol

3 - Methylbutan - 1 - ol

3 - Metil - butanolo (Italian)

Alcool amilico (Italian)

Alcool isoamylique (French)

Amylowy alkohol (Polish)

Fermentation amyl alcohol

Iso - amylalkohol (German)

Isoamyl alcohol

Isoamyl alcohol (ACGIH)

Isoamyl alcohol, primary (OSHA)

Isoamyl alkohol (Czech)

Isoamylol

Isobutylcarbinol

Isopentanol

Isopentyl alcohol

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
eye
human 150 ppm N/R JIHTAB 25,282,1943
eye
rabbit 20 mg/24 hour moderate 85JCAE -,196,1986
skin
rabbit 20 mg/24 hour moderate 85JCAE -,196,1986

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 27 gm/kg/75 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Leukemia ARGEAR 45,19,1975
subcutaneous
rat lowest published toxic dose: 3,800 mg/kg/85 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Leukemia ARGEAR 45,19,1975

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
human lowest published toxic concentration: 150 ppm Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes JIHTAB 25,282,1943
intraperitoneal
mouse lowest published lethal dose: 233 mg/kg N/R FCTXAV 16,785,1978
intraperitoneal
rat lowest published lethal dose: 813 mg/kg N/R AEPPAE 132,214,1928
intravenous
cat lowest published lethal dose: 210 mg/kg N/R FCTXAV 16,785,1978
intravenous
mouse lethal dose (50 percent kill): 234 mg/kg N/R AIPTAK 135,330,1962
intravenous
rabbit lowest published lethal dose: 1,570 mg/kg Behavioral: Antipsychotic FCTXAV 16,785,1978
oral
rat lethal dose (50 percent kill): 1,300 mg/kg Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes

Blood: Other changes SAMJAF 43,795,1969
oral
rat lethal dose (50 percent kill): 4,300 mg/kg N/R VCVGK* -,108,1984
oral
rabbit lethal dose (50 percent kill): 3,438 mg/kg Eye: Corneal damage

Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Dyspnea IMSUAI 41,31,1972
subcutaneous
mouse lowest published lethal dose: 7,480 mg/kg N/R FCTXAV 16,785,1978
skin
rabbit lethal dose (50 percent kill): 3,970 無/kg N/R AIHAAP 30,470,1969

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 100 ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 100 ppm;short term exposure limit 125 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 125 ppm DTLVS* TLV/BEI,2002
TOXICOLOGY REVIEW
MUREAV 539,77,2003

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (360 mg/m³) DTLVS* 3,139,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (360 mg/m³) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (360 mg/m³) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (360 mg/m³) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (360 mg/m³) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 100 ppm (360 mg/m³), short term exposure limit 125 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 100 ppm (360 mg/m³), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 100 ppm (361 mg/m³), short term exposure limit 125 ppm (452 mg/m³), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 100 ppm (360 mg/m³), JAN1999
Occupational Exposure Limit - FRANCE VME 100 ppm (360 mg/m³), JAN1999
Occupational Exposure Limit - GERMANY MAK 100 ppm (360 mg/m³), JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 100 ppm (360 mg/m³), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 360 mg/m³, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 100 ppm (360 mg/m³), JAN1993
Occupational Exposure Limit - RUSSIA time-weighted average 100 ppm, short term exposure limit 5 mg/m³, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 100 ppm (360 mg/m³), KZG- week 200 ppm (720 mg/m³), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 100 ppm (360 mg/m³), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 100 ppm (366 mg/m³), short term exposure limit 125 ppm (458 mg/m³), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 125 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 125 ppm

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ISOAMYL ALCOHOL, primary-air time-weighted average 100 ppm;
short term exposure limit 125 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 40380;
Number of Industries 16;
Total Number of Facilities 2,530;
Number of Occupations 18;
Total Number of Employees Exposed 24,606
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 40380;
Number of Industries 43;
Total Number of Facilities 3,803;
Number of Occupations 49;
Total Number of Employees Exposed 65,499;
Total Number of Female Employees Exposed 22,006

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols III, 1402

REFERENCES:
CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
SAMJAF South African Medical Journal. (Medical Assoc. of South Africa, Secy., P.O. Box 643, Cape Town, S. Africa) V.6- 1932-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

NIOSH PROFILE (ALCOHOLS), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

SYNONYMS:
2 - Methyl - 4 - butanol 3 - Methyl butanol 3 - Methyl - 1 - butanol 3 - Methylbutan - 1 - ol 3 - Metil - butanolo (Italian) Alcool amilico (Italian) Alcool isoamylique (French) Amylowy alkohol (Polish) Fermentation amyl alcohol	Iso - amylalkohol (German) Isoamyl alcohol Isoamyl alcohol (ACGIH) Isoamyl alcohol, primary (OSHA) Isoamyl alkohol (Czech) Isoamylol Isobutylcarbinol Isopentanol Isopentyl alcohol

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
eye human	150 ppm	N/R	JIHTAB 25,282,1943
eye rabbit	20 mg/24 hour	moderate	85JCAE -,196,1986
skin rabbit	20 mg/24 hour	moderate	85JCAE -,196,1986

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral rat	lowest published toxic dose: 27 gm/kg/75 week- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Blood: Leukemia	ARGEAR 45,19,1975
subcutaneous rat	lowest published toxic dose: 3,800 mg/kg/85 week- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Blood: Leukemia	ARGEAR 45,19,1975

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation human	lowest published toxic concentration: 150 ppm	Olfaction: Other olfaction effects Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Other changes	JIHTAB 25,282,1943
intraperitoneal mouse	lowest published lethal dose: 233 mg/kg	N/R	FCTXAV 16,785,1978
intraperitoneal rat	lowest published lethal dose: 813 mg/kg	N/R	AEPPAE 132,214,1928
intravenous cat	lowest published lethal dose: 210 mg/kg	N/R	FCTXAV 16,785,1978
intravenous mouse	lethal dose (50 percent kill): 234 mg/kg	N/R	AIPTAK 135,330,1962
intravenous rabbit	lowest published lethal dose: 1,570 mg/kg	Behavioral: Antipsychotic	FCTXAV 16,785,1978
oral rat	lethal dose (50 percent kill): 1,300 mg/kg	Liver: Fatty liver degeneration Kidney, Ureter, and Bladder: Other changes Blood: Other changes	SAMJAF 43,795,1969
oral rat	lethal dose (50 percent kill): 4,300 mg/kg	N/R	VCVGK* -,108,1984
oral rabbit	lethal dose (50 percent kill): 3,438 mg/kg	Eye: Corneal damage Cardiac: Pulse rate decreased with fall in BP Lung, Thorax, or Respiration: Dyspnea	IMSUAI 41,31,1972
subcutaneous mouse	lowest published lethal dose: 7,480 mg/kg	N/R	FCTXAV 16,785,1978
skin rabbit	lethal dose (50 percent kill): 3,970 無/kg	N/R	AIHAAP 30,470,1969

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value	time-weighted average 100 ppm	DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value	time-weighted average 100 ppm;short term exposure limit 125 ppm	DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value	short term exposure limit 125 ppm	DTLVS* TLV/BEI,2002
TOXICOLOGY REVIEW		MUREAV 539,77,2003

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air	time-weighted average 100 ppm (360 mg/m³)	DTLVS* 3,139,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8 hour time-weighted average 100 ppm (360 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8 hour time-weighted average 100 ppm (360 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8 hour time-weighted average 100 ppm (360 mg/m³)	CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8 hour time-weighted average 100 ppm (360 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA	time-weighted average 100 ppm (360 mg/m³), short term exposure limit 125 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA	MAK 100 ppm (360 mg/m³), JAN1999
Occupational Exposure Limit - BELGIUM	time-weighted average 100 ppm (361 mg/m³), short term exposure limit 125 ppm (452 mg/m³), JAN1993
Occupational Exposure Limit - DENMARK	time-weighted average 100 ppm (360 mg/m³), JAN1999
Occupational Exposure Limit - FRANCE	VME 100 ppm (360 mg/m³), JAN1999
Occupational Exposure Limit - GERMANY	MAK 100 ppm (360 mg/m³), JAN1999
Occupational Exposure Limit - JAPAN	Occupational Exposure Limit 100 ppm (360 mg/m³), JAN1999
Occupational Exposure Limit - THE NETHERLANDS	MAC-TGG 360 mg/m³, 2003
Occupational Exposure Limit - THE PHILIPPINES	time-weighted average 100 ppm (360 mg/m³), JAN1993
Occupational Exposure Limit - RUSSIA	time-weighted average 100 ppm, short term exposure limit 5 mg/m³, JAN1993
Occupational Exposure Limit - SWITZERLAND	MAK- week 100 ppm (360 mg/m³), KZG- week 200 ppm (720 mg/m³), JAN1999
Occupational Exposure Limit - TURKEY	time-weighted average 100 ppm (360 mg/m³), JAN1993
Occupational Exposure Limit - UNITED KINGDOM	time-weighted average 100 ppm (366 mg/m³), short term exposure limit 125 ppm (458 mg/m³), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA	American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; short term exposure limit 125 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM	American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 125 ppm

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ISOAMYL ALCOHOL, primary-air	time-weighted average 100 ppm; short term exposure limit 125 ppm	NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 40380; Number of Industries 16; Total Number of Facilities 2,530; Number of Occupations 18; Total Number of Employees Exposed 24,606
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: 40380; Number of Industries 43; Total Number of Facilities 3,803; Number of Occupations 49; Total Number of Employees Exposed 65,499; Total Number of Female Employees Exposed 22,006

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols III, 1402

REFERENCES:
CODEN	REFERENCE
85JCAE	"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AEPPAE	Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AIHAAP	American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AIPTAK	Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
ARGEAR	Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949-
CFRGBR	Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS*	The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTXAV	Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
IMSUAI	Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
JIHTAB	Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH*	National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
SAMJAF	South African Medical Journal. (Medical Assoc. of South Africa, Secy., P.O. Box 643, Cape Town, S. Africa) V.6- 1932-
VCVGK*	"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.