The Registry of Toxic Effects of Chemical Substances

1,4 - Butanediol

RTECS #: EK0525000

CAS #: 110-63-4

UPDATE: November 2004 MW: 90.14 MF: C4H10O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Agrisynth B1D
  2. Butanediol
  3. Butane - 1,4 - diol
  4. 1,4 - Butylene glycol
  5. 1,4 - Dihydroxybutane
  1. DIOL 14B
  2. Sucol B
  3. Tetramethylene 1,4 - diol
  4. 1,4 - Tetramethylene glycol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 15 gm/m3/4 hour Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		INHTE5 3,379,1991
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,650 mg/kg N/R TXAPA9 49,385,1979
intraperitoneal
mouse 		lowest published lethal dose: 500 mg/kg N/R VCVGK* -,152,1984
intraperitoneal
rat 		lethal dose (50 percent kill): 1,070 mg/kg N/R JPPMAB 26,597,1974
intraperitoneal
rat 		lowest published toxic dose: 250 mg/kg Behavioral: Ataxia VCVGK* -,152,1984
intraperitoneal
rat 		lowest published toxic dose: 178 mg/kg Behavioral: Alteration of operant conditioning EJPHAZ 484,259,2004
oral
guinea pig 		lethal dose (50 percent kill): 1,200 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Blood: Other changes 		HYSAAV 33(1-3),41,1968
oral
guinea pig 		lethal dose (50 percent kill): 1,200 mg/kg N/R VCVGK* -,152,1984
oral
man 		lowest published toxic dose: 42.8 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma 		CTOXAO 40,77,2002
oral
mouse 		lethal dose (50 percent kill): 2,062 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Blood: Other changes 		HYSAAV 33(1-3),41,1968
oral
mouse 		lethal dose (50 percent kill): 2,062 mg/kg N/R VCVGK* -,152,1984
oral
rat 		lethal dose (50 percent kill): 1,525 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Blood: Other changes 		HYSAAV 33(1-3),41,1968
oral
rat 		lethal dose (50 percent kill): 1,525 mg/kg N/R VCVGK* -,152,1984
oral
rabbit 		lethal dose (50 percent kill): 2,531 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Blood: Other changes 		HYSAAV 33(1-3),41,1968
oral
rabbit 		lethal dose (50 percent kill): 2,531 mg/kg N/R VCVGK* -,152,1984
rectal
man 		lowest published lethal dose: 429 mg/kg N/R PHARAT 3,110,1948
unreported route
woman 		lowest published lethal dose: 300 mg/kg Behavioral: Altered sleep time (including change in righting reflex) PHARAT 3,110,1948


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 1,500 mg/m3/4 hour/122 day- intermittent Lung, Thorax, or Respiration: Fibrosis (interstitial) VCVGK* -,152,1994
inhalation
rat 		lowest published toxic concentration: 5,200 mg/m3/6 hour/2 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		INHTE5 3,379,1991
intraperitoneal
rat 		lowest published toxic dose: 36,960 mg/kg/6 week- intermittent Behavioral: Tolerance

Behavioral: Alteration of operant conditioning 		EJPHAZ 483,259,2004
oral
rat 		lowest published toxic dose: 5,460 mg/kg/26 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Other carbohydrates 		GISAAA 33(1),37,1968
oral
rat 		lowest published toxic dose: 14 gm/kg/28 day- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		PJOMEY 3,421,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0752;
Number of Industries 7;
Total Number of Facilities 226;
Number of Occupations 22;
Total Number of Employees Exposed 16,785
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0752;
Number of Industries 21;
Total Number of Facilities 759;
Number of Occupations 25;
Total Number of Employees Exposed 16,811;
Total Number of Female Employees Exposed 3,870


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in production of polyurethanes, plasticizers, elastomers and surface coatings
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Toxicity studies, RPT# TOX-54, October 2000


REFERENCES:

CODEN
REFERENCE
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946-
PJOMEY Polish Journal of Occupational Medicine. (Polish Journal of Occupational Medicine, P.O. Box 199, 90-950 Lodz, Poland) V.1-3; 1988-90. Discontinued.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used in production of polyurethanes, plasticizers, elastomers and surface coatings

NIOSH PROFILE (GLYCOLS), SRI, 2/77

NIOSH PROFILE (GLYCOLS), SRC, 2/82

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

 Click Here for Additional Information about RTECS