The Registry of Toxic Effects of Chemical Substances

1,3 - Butanediol

RTECS #: EK0440000

CAS #: 107-88-0

UPDATE: August 2003 MW: 90.14 MF: C4H10O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,3 - Butandiol (German)
  2. Butane - 1,3 - diol
  3. 1,3 - Butylenglykol (German)
  4. beta - Butylene glycol
  1. 1,3 - Butylene glycol
  2. 1,3 - Dihydroxybutane
  3. Methyltrimethylene glycol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg mild AJOPAA 29,1363,1946
eye
rabbit 		500 mg/24 hour mild 85JCAE -,207,1986
skin
rabbit 		500 mg/24 hour mild 85JCAE -,207,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 42,360 mg/kg (6-15 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) JACTDZ 5(4),189,1986


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 10,276 mg/kg N/R TXAPA9 49,385,1979
intraperitoneal
rat 		lowest published toxic dose: 5,890 mg/kg Behavioral: Ataxia VCVGK* -,151,1984
oral
guinea pig 		lethal dose (50 percent kill): 11 gm/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes 		JIHTAB 23,259,1941
oral
guinea pig 		lethal dose (50 percent kill): 11,000 mg/kg N/R VCVGK* -,151,1984
oral
mouse 		lethal dose (50 percent kill): 12,980 mg/kg N/R JAPMA8 45,669,1956
oral
rat 		lethal dose (50 percent kill): 18,610 mg/kg N/R JIHTAB 23,259,1941
subcutaneous
rat 		lethal dose (50 percent kill): 20,000 mg/kg N/R VCVGK* -,151,1984
skin
rabbit 		lethal dose (50 percent kill): >20 gm/kg N/R NPIRI* 1,14,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mammal (species unspecified) 		lowest published toxic dose: 12,000 mg/kg/12 day- intermittent Behavioral: Abuse

Behavioral: Alteration of classical conditioning

Endocrine: Change in LH 		VCVGK* -,152,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
JACTDZ 4(5),223,1985


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,298,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83068;
Number of Industries 13;
Total Number of Facilities 1,532;
Number of Occupations 22;
Total Number of Employees Exposed 36,963
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83068;
Number of Industries 13;
Total Number of Facilities 1,070;
Number of Occupations 17;
Total Number of Employees Exposed 19,336;
Total Number of Female Employees Exposed 5,266


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in brake fluid, also used as stabilizer for pharmaceuticals and intermediate
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1996: Glycols, 5523


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used in brake fluid, also used as stabilizer for pharmaceuticals and intermediate

NIOSH PROFILE (GLYCOLS), SRI, 2/77

NIOSH PROFILE (GLYCOLS), SRC, 2/82

RTECS Compound Description:
   Reproductive Effector
   Primary Irritant

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