The Registry of Toxic Effects of Chemical Substances

n - Butanethiol

RTECS #: EK6300000

CAS #: 109-79-5

UPDATE: November 2004 MW: 90.20 MF: C4H10S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Butanethiol (OSHA)
  2. Butyl mercaptan
  3. Butyl mercaptan (DOT:OSHA)
  1. NCI - C60866
  2. n - Butyl mercaptan
  3. n - Butyl mercaptan (ACGIH)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		83 mg N/R AIHAAP 19,171,1958


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 68 ppm/6 hour (6-16 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		FAATDF 8,170,1987


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lethal concentration (50 percent kill): 770 ppm/30 minute N/R 85JCAE -,982,1986
inhalation
mouse 		lethal concentration (50 percent kill): 2,500 ppm/4 hour Lung, Thorax, or Respiration: Respiratory stimulation

Behavioral: Somnolence (general depressed activity)

Eye: Lacrimation 		AIHAAP 19,171,1958
inhalation
rat 		lethal concentration (50 percent kill): 4,020 ppm/4 hour Lung, Thorax, or Respiration: Respiratory stimulation

Behavioral: Somnolence (general depressed activity)

Eye: Lacrimation 		AIHAAP 19,171,1958
intraperitoneal
rat 		lethal dose (50 percent kill): 399 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression

Behavioral: Coma 		AIHAAP 19,171,1958
oral
mouse 		lethal dose (50 percent kill): 3 gm/kg N/R 85JCAE -,982,1986
oral
rat 		lethal dose (50 percent kill): 1,500 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression

Behavioral: Coma 		AIHAAP 19,171,1958


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 1,114 ppm/6 hour/2 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** OTS0555470


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Active registration RBREV* -,357,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 ppm (1.5 mg/m3) DTLWS* 3,12,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 10 ppm (35 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 ppm (1.5 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 ppm (1.5 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 10 ppm (35 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRIA MAK 0.5 ppm (1.5 mg/m3), JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 0.5 ppm (1.5 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.5 ppm (1.5 mg/m3), short term exposure limit 1.5 ppm (4.5 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 0.5 ppm (1.5 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 0.5 ppm (1.5 mg/m3), JAN1999
Occupational Exposure Limit - INDIA time-weighted average 0.5 ppm (1.5 mg/m3), JAN1993
Occupational Exposure Limit - POLAND time-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1.5 mg/m3, 2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 ppm (1.9 mg/m3), KZG- week 1 ppm (3.8 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 10 ppm (35 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.5 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.5 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1-BUTANETHIOL-air ceiling concentration 0.5 ppm/15 minute NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 13785;
Number of Industries 2;
Total Number of Facilities 71;
Number of Occupations 7;
Total Number of Employees Exposed 2,764
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 13785;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 8;
Total Number of Employees Exposed 106;
Total Number of Female Employees Exposed 3


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Mercaptans, 2542
NIOSH Analytical Method, 1996: n-Butyl mercaptan, 2525


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998

NIOSH PROFILE (MERCAPTANS), SRC, 10/77

RTECS Compound Description:
   Reproductive Effector
   Primary Irritant

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