The Registry of Toxic Effects of Chemical Substances

Butane, 1,1' - oxybis -

RTECS #: EK5425000

CAS #: 142-96-1

UPDATE: February 2004 MW: 130.26 MF: C8H18O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. 1 - Butoxybutane
  2. Butyl ether
  3. n - Butyl ether
  4. Dibutyl ether
  5. Di - n - butyl ether
  1. n - Dibutyl ether
  2. Dibutyl oxide
  3. Ether butylique (French)
  4. 1,1' - Oxybis (butane)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
human 		200 ppm/15 minute N/R JIHTAB 28,262,1946
skin
rabbit 		380 mg open irritation test mild UCDS** 7/8/1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 200 ppm Olfaction: Other olfaction effects

Eye: Conjunctiva irritation 		JIHTAB 28,262,1946
inhalation
human 		lowest published toxic concentration: 1,000 mg/m3/3 minute Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough 		VCVGK* -,269,1994
inhalation
mouse 		lethal concentration (50 percent kill): 169 gm/m3/15 minute Behavioral: General anesthetic ANESAV 11,455,1950
inhalation
mouse 		lowest published lethal concentration: 60,000 mg/m3/2 hour Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration 		VCVGK* -,269,1994
inhalation
mouse 		lowest published toxic concentration: 10,000 mg/m3/30 minute Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration 		VCVGK* -,269,1994
inhalation
mouse 		lowest published toxic concentration: 10,000 mg/m3/75 minute Behavioral: General anesthetic

Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration 		VCVGK* -,269,1994
inhalation
rat 		lowest published lethal concentration: 4,000 ppm/4 hour N/R AMIHBC 10,61,1954
inhalation
rat 		lowest published lethal concentration: 20,200 mg/m3/4 hour Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration 		VCVGK* -,269,1994
intravenous
mouse 		lowest published lethal dose: 258 mg/kg Behavioral: Altered sleep time (including change in righting reflex) APTOA6 37,56,1975
oral
mouse 		lethal dose (50 percent kill): 567 mg/kg Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration 		VCVGK* -,269,1994
oral
mouse 		lowest published toxic dose: 455 mg/kg Behavioral: Irritability

Liver: Fatty liver degeneration 		VCVGK* -,269,1994
oral
rat 		lethal dose (50 percent kill): 7,400 mg/kg N/R AMIHBC 10,61,1954
skin
rabbit 		lethal dose (50 percent kill): 10 mL/kg N/R VCVGK* -,269,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84736;
Number of Industries 3;
Total Number of Facilities 97;
Number of Occupations 5;
Total Number of Employees Exposed 1,004
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84736;
Number of Industries 4;
Total Number of Facilities 468;
Number of Occupations 18;
Total Number of Employees Exposed 6,292;
Total Number of Female Employees Exposed 235


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Human Data
   Primary Irritant

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