The Registry of Toxic Effects of Chemical Substances

Butane, 2 - methoxy - 2 - methyl -

RTECS #: EK4421000

CAS #: 994-05-8

UPDATE: August 2004 MW: 102.20 MF: C6H14O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. tert - Amyl methyl ether
  2. 1,1 - Dimethylpropyl methyl ether
  3. Ether, methyl tert - pentyl (6CI,7CI,8CI)
  4. 2 - Methoxy - 2 - methylbutane
  5. Methyl tert - amyl ether
  1. Methyl 1,1 - dimethylpropyl ether
  2. Methyl tert - pentyl ether
  3. tert - Pentyl methyl ether
  4. TAME
  5. TAME (ether)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 µL/24 hour severe NTIS** OTS0557627
skin
rabbit 		500 µL/4 hour severe NTIS** OTS0557664


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 3,500 ppm/6 hour (6-19 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		NTIS** OTS0558880
inhalation
rat 		lowest published toxic concentration: 3,500 ppm/6 hour (6-19 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		NTIS** OTS0558879


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 27,400 mg/m3 Brain and Coverings: Increased intracranial pressure

Behavioral: General anesthetic 		VCVGK* -,269,1994
inhalation
rat 		lethal concentration (50 percent kill): >5,400 mg/m3/4 hour Lung, Thorax, or Respiration: Pulmonary emboli NTIS** OTS0557658
inhalation
rat 		lethal concentration (50 percent kill): 31,800 mg/m3 Brain and Coverings: Increased intracranial pressure

Behavioral: General anesthetic 		VCVGK* -,269,1994
oral
mouse 		lethal dose (50 percent kill): 3,333 mg/kg Brain and Coverings: Increased intracranial pressure

Behavioral: General anesthetic 		VCVGK* -,269,1994
oral
rat 		lethal dose (50 percent kill): 1,602 mg/kg Behavioral: Ataxia

Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Body temperature decrease 		NTIS** OTS0557624
oral
rat 		lethal dose (50 percent kill): 3,500 mg/kg Brain and Coverings: Increased intracranial pressure

Behavioral: General anesthetic 		VCVGK* -,269,1994
skin
rabbit 		lethal dose : >3,160 mg/kg Olfaction: Other olfaction effects

Gastrointestinal: Other changes

Musculoskeletal: Other changes 		NTIS** OTS0557626


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 2,500 ppm/6 hour/13 week- intermittent Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TOXID9 42,251,1998
inhalation
rat 		lowest published toxic concentration: 2,000 ppm/6 hour/4 week- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Coma

Liver: Liver function tests impaired 		NTIS** OTS0535711
inhalation
rat 		lowest published toxic concentration: 3,500 ppm/6 hour/13 week- intermittent Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TOXID9 42,251,1998
oral
rat 		lowest published toxic dose: 14 gm/kg/28 day- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in adrenal weight 		JJATDK 15,313,1995
oral
rat 		lowest published toxic dose: 4.2 gm/kg/2 week- continuous Reproductive: Effects on fertility: Other measures of fertility REPTED 17,273,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 20 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an oxygenate to reduce carbon monoxide emissions
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as an oxygenate to reduce carbon monoxide emissions

RTECS Compound Description:
   Reproductive Effector
   Primary Irritant

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