The Registry of Toxic Effects of Chemical Substances

2,3 - Butanedione

RTECS #: EK2625000

CAS #: 431-03-8

UPDATE: November 2003 MW: 86.10 MF: C4H6O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Biacetyl
  2. 2,3 - Butadione
  3. Diacetyl
  4. 2,3 - Diketobutane
  1. Dimethyl diketone
  2. Dimethylglyoxal
  3. Glyoxal, dimethyl -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg/24 hour moderate FCTXAV 17,765,1979


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
unscheduled DNA synthesis oral
rat 		1,500 mg/kg JJCREP 76,809,1985
mutation in microorganisms Salmonella typhimurium 1 mg/plate (+enzymatic activation step) MUREAV 67,367,1979


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 400 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)

Vascular: Regional or general arteriolar or venous dilation 		FCTXAV 7,571,1969
oral
guinea pig 		lethal dose (50 percent kill): 990 mg/kg Behavioral: Ataxia

Behavioral: Coma

Lung, Thorax, or Respiration: Dyspnea 		FCTXAV 2,327,1964
oral
rat 		lethal dose (50 percent kill): 1,580 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		FCTXAV 2,327,1964
oral
rat 		lethal dose (50 percent kill): 3,000 mg/kg N/R VCVGK* -,448,1994
skin
rabbit 		lethal dose (50 percent kill): >5 gm/kg N/R FCTXAV 17,765,1979


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 48,600 mg/kg/90 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in adrenal weight

Blood: Pigmented or nucleated red blood cells 		FCTXAV 7,571,1969
oral
rat 		lowest published toxic dose: 48,600 mg/kg/90 day- intermittent Gastrointestinal: Ulceration or bleeding from stomach

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight 		VCVGK* -,448,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84595;
Number of Industries 3;
Total Number of Facilities 126;
Number of Occupations 6;
Total Number of Employees Exposed 1,503
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84595;
Number of Industries 3;
Total Number of Facilities 185;
Number of Occupations 13;
Total Number of Employees Exposed 3,438;
Total Number of Female Employees Exposed 1,628


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used to flavour foods
NTP Carcinogenesis studies; selected, October 2000


REFERENCES:

CODEN
REFERENCE
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used to flavour foods

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Primary Irritant

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