The Registry of Toxic Effects of Chemical Substances

Butane, 1 - chloro -

RTECS #: EJ6300000

CAS #: 109-69-3

UPDATE: November 2004 MW: 92.58 MF: C4H9Cl


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Butyl chloride
  2. n - Butyl chloride
  3. 1 - Chlorobutane
  1. Chlorure de butyle (French)
  2. NCI - C06155
  3. n - Propylcarbinyl chloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in mammalian somatic cells mouse lymphocyte 500 mg/L NTPTR* NTP-TR-312,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 13,927 mg/kg (1-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death GISAAA 44(3),11,1979


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 257,500 mg/kg/103 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		NTIS** PB86-218526/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 8,000 ppm/4 hour N/R AMIHBC 10,61,1954
oral
mouse 		lethal dose (50 percent kill): 5,600 mg/kg N/R VCVGH* -,401,1990
oral
rat 		lethal dose (50 percent kill): 2,200 mg/kg N/R VCVGH* -,401,1990
skin
rabbit 		lowest published lethal dose: 20 gm/kg N/R 34ZIAG -,745,1969
unreported route
guinea pig 		lethal dose (50 percent kill): 8 gm/kg N/R VRDEA5 (7),105,1979
unreported route
mouse 		lethal dose (50 percent kill): 5,600 mg/kg N/R GISAAA 44(3),11,1979
unreported route
rat 		lethal dose (50 percent kill): 2,200 mg/kg N/R VRDEA5 (7),105,1979


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 21 gm/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-312,1986
oral
mouse 		lowest published toxic dose: 65 gm/kg/13 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-312,1986
oral
rat 		lowest published toxic dose: 364 mg/kg/26 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		GISAAA 44(3),11,1979
oral
rat 		lowest published toxic dose: 10,500 mg/kg/14 day- intermittent Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-312,1986
oral
rat 		lowest published toxic dose: 32,500 mg/kg/13 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-312,1986


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - NORWAY time-weighted average 0.5 ppm (1.5 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, Skin, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3168;
Number of Industries 2;
Total Number of Facilities 33;
Number of Occupations 4;
Total Number of Employees Exposed 3,202;
Total Number of Female Employees Exposed 880


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a chemical intermediate, pharmaceutical and veterinary drug
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);no evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.
VRDEA5 Vrachebnoe Delo. Medical Practice. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1918-

Used as a chemical intermediate, pharmaceutical and veterinary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector

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