The Registry of Toxic Effects of Chemical Substances

Butane, 1,4 - bis (2,3 - epoxypropoxy) -

RTECS #: EJ5100000

CAS #: 2425-79-8

UPDATE: December 1998 MW: 202.28 MF: C10H18O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Araldit DY 026
  2. 1,4 - Butane diglycidyl ether
  3. 1,4 - Bis (2,3 - epoxypropoxy) butane
  4. 1,4 - Bis (glycidyloxy) butane
  5. Butanediol diglycidyl ether
  6. Butane - 1:4 - diol diglycidyl ether
  7. CD 15006 A
  1. 1,4 - Butanediol diglycidyl ether
  2. 2,2' - (1,4 - Butanediylbis (oxymethylene) ) bisoxirane
  3. ChS - RR2
  4. 1,4 - Diglycidloxybutane
  5. Grilonit RV 1806
  6. Oxirane, 2,2' - (1,4 - butanediylbis (oxymethylene) ) bis - (9CI)
  7. TK 10352


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg moderate AMIHAB 20,390,1959
skin
rabbit 		10 mg/24 hour moderate AMIHAB 20,390,1959


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis intraperitoneal
rat 		100 mg/kg BJPCAL 6,235,1951
mutation in microorganisms Salmonella typhimurium 333 µg/plate (+enzymatic activation step) MUREAV 172,105,1986
other mutation test systems Escherichia coli 300 µmol/L MUREAV 231,205,1990
sister chromatid exchange hamster lung 6,250 nmol/L MUREAV 249,55,1991
specific locus test oral
Drosophila melanogaster 		28,400 ppm EMMUEG 23,51,1994
heritable translocation test oral
Drosophila melanogaster 		28 ppb EMMUEG 23,51,1994


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 32,960 mg/kg/2 year- intermittent Nutritional and Gross Metabolic: Dehydration

Skin and Appendages: Tumors 		NTIS** OTS0571421


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration : >250 ppm/6 hour N/R NTIS** OTS0555389
oral
hamster 		lethal dose (50 percent kill): 3,462 mg/kg Eye: Other eye effects

Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Hair 		NTIS** OTS0523586
oral
mouse 		lethal dose (50 percent kill): 1,100 µg/kg N/R NTIS** OTS0555389
oral
rat 		lethal dose (50 percent kill): 1,134 mg/kg Eye: Other eye effects

Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair 		TSCAT* OTS0206386
skin
rabbit 		lethal dose (50 percent kill): 1,130 mg/kg N/R AMIHAB 20,390,1959


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 8,470 mg/kg/11 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0555389


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2226;
Number of Industries 3;
Total Number of Facilities 43;
Number of Occupations 3;
Total Number of Employees Exposed 606;
Total Number of Female Employees Exposed 51


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8891
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

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