The Registry of Toxic Effects of Chemical Substances
Bromine RTECS #: EF9100000
CAS #: 7726-95-6
The Registry of Toxic Effects of Chemical Substances
Bromine |
| UPDATE: November 2004 | MW: 159.82 | MF: Br2 |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
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N/R
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N/R
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N/R
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N/R
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | cat
lowest published lethal concentration: 1,200 mg/m3
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N/R
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VCVN5* -,389,1989
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inhalation | cat
lowest published lethal concentration: 150 mg/m3/7 hour
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Lung, Thorax, or Respiration: Cough | Lung, Thorax, or Respiration: Dyspnea
VCVN5* -,389,1989
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inhalation | guinea pig
lowest published lethal concentration: 1,200 mg/m3
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N/R
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VCVN5* -,389,1989
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inhalation | guinea pig
lowest published lethal concentration: 150 mg/m3/7 hour
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Lung, Thorax, or Respiration: Cough | Lung, Thorax, or Respiration: Dyspnea
VCVN5* -,389,1989
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inhalation | human
lowest published lethal concentration: 1,000 ppm
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N/R
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34ZIAG -,645,1969
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inhalation | human
lowest published toxic concentration: 13 mg/m3
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Lung, Thorax, or Respiration: Cough
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VCVN5* -,390,1989
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inhalation | human
lowest published toxic concentration: 11 mg/m3
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Lung, Thorax, or Respiration: Respiratory depression
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VCVN5* -,390,1989
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inhalation | human
lowest published lethal concentration: 220 mg/m3
|
N/R
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VCVN5* -,390,1989
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inhalation | mammal (species unspecified)
lowest published toxic concentration: 50 mg/m3
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Cardiac: Other changes | Endocrine: Other changes
VCVN5* -,389,1989
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inhalation | mammal (species unspecified)
lowest published toxic concentration: 100 mg/m3
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Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
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VCVN5* -,389,1989
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inhalation | mouse
lethal concentration (50 percent kill): 750 ppm/9 minute
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N/R
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AIHAAP 39,129,1978
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inhalation | mouse
lethal concentration (50 percent kill): 2,900 mg/m3
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N/R
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VCVN5* -,389,1989
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inhalation | rat
lethal concentration (50 percent kill): 2,700 mg/m3
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Lung, Thorax, or Respiration: Other changes
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GTPZAB 20(3),36,1976
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inhalation | rat
lethal concentration (50 percent kill): 2,700 mg/m3
|
N/R
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VCVN5* -,389,1989
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inhalation | rat
lowest published toxic concentration: 10 mg/m3/4 hour
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Olfaction: Change in sensation of smell | Lung, Thorax, or Respiration: Respiratory depression
VCVN5* -,389,1989
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inhalation | rabbit
lowest published lethal concentration: 180 ppm/6.5 hour
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N/R
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HBTXAC 1,324,1955
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inhalation | rabbit
lowest published lethal concentration: 1,200 mg/m3
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N/R
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VCVN5* -,389,1989
|
inhalation | rabbit
lowest published lethal concentration: 150 mg/m3/7 hour
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Lung, Thorax, or Respiration: Cough | Lung, Thorax, or Respiration: Dyspnea
VCVN5* -,389,1989
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oral | guinea pig
lethal dose (50 percent kill): 5,500 mg/kg
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N/R
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VCVN5* -,389,1989
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oral | human
lowest published lethal dose: 14 mg/kg
|
N/R
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34ZIAG -,645,1969
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oral | mammal (species unspecified)
lethal dose (50 percent kill): 440 mg/kg
|
N/R
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GISAAA 39(4),86,1974
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oral | mouse
lethal dose (50 percent kill): 3,100 mg/kg
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N/R
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VCVN5* -,389,1989
|
oral | rat
lethal dose (50 percent kill): 1,700 mg/kg
|
N/R
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VCVN5* -,389,1989
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oral | rabbit
lethal dose (50 percent kill): 2,500 mg/kg
|
N/R
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VCVN5* -,389,1989
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
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inhalation | rat
lowest published toxic concentration: 1,400 µg/m3/17 week- intermittent
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Lung, Thorax, or Respiration: Respiratory depression | Endocrine: Evidence of thyroid hypofunction Endocrine: Changes in thyroid weight
GTPZAB 20(3),36,1976
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inhalation | rat
lowest published toxic concentration: 12.4 mg/m3/24 hour/17 week- continuous
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Cardiac: Other changes | Endocrine: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVN5* -,390,1989
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inhalation | rat
lowest published toxic concentration: 1.4 mg/m3/24 hour/17 week- continuous
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Olfaction: Other olfaction effects
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VCVN5* -,390,1989
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inhalation | rabbit
lowest published toxic concentration: 12.4 mg/m3/24 hour/17 week- continuous
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Lung, Thorax, or Respiration: Other changes | Liver: Other changes Kidney, Ureter, and Bladder: Other changes
VCVN5* -,390,1989
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inhalation | rabbit
lowest published toxic concentration: 1.4 mg/m3/24 hour/17 week- continuous
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Olfaction: Other olfaction effects
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VCVN5* -,390,1989
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oral | rat
lowest published toxic dose: 3,094 mg/kg/13 week- intermittent
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Endocrine: Hyperglycemia | Skin and Appendages: Other: Hair Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
VCVN5* -,390,1989
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unreported route | rat
lowest published toxic dose: 3,375 mg/kg/15 day- intermittent
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Endocrine: Estrogenic
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VCVN5* -,390,1989
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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time-weighted average 0.1 ppm
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DTLVS* TLV/BEI,2003
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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short term exposure limit 0.2 ppm
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DTLVS* TLV/BEI,2003
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TOXICOLOGY REVIEW
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KOTTAM 11,1300,1975
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TOXICOLOGY REVIEW
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FOREAE 7,313,1942
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TOXICOLOGY REVIEW
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CLCHAU 19,361,1973
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988
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PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
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FEREAC 54,7740,1989
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Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF
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PESTICIDES: RED Completed
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RBREV* -,298,1998
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Mine Safety and Health Administration (MSHA) STANDARD - air
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time-weighted average 0.1 ppm (0.7 mg/m3)
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DTLVS* 3,27,1971
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)
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8 hour time-weighted average 0.1 ppm (0.7 mg/m3)
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CFRGBR 29,1910.1000,1994
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)
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8 hour time-weighted average 0.1 ppm (0.7 mg/m3)
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CFRGBR 29,1926.55,1994
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)
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8 hour time-weighted average 0.1 ppm (0.7 mg/m3)
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CFRGBR 29,1915.1000,1993
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)
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8 hour time-weighted average 0.1 ppm (0.7 mg/m3)
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CFRGBR 41,50-204.50,1994
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Occupational Exposure Limit - ARAB Republic of Egypt
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time-weighted average 0.1 ppm (0.7 mg/m3), JAN1993
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Occupational Exposure Limit - AUSTRALIA
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time-weighted average 0.1 ppm (0.7 mg/m3), short term exposure limit 0.3 ppm (2 mg/m3), JAN1993
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Occupational Exposure Limit - AUSTRIA
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MAK 0.1 ppm (0.7 mg/m3), JAN1999
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Occupational Exposure Limit - BELGIUM
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time-weighted average 0.1 ppm (0.66 mg/m3), short term exposure limit 0.3 ppm, JAN1993
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Occupational Exposure Limit - DENMARK
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time-weighted average 0.1 ppm (0.7 mg/m3), JAN1999
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Occupational Exposure Limit - FINLAND
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short term exposure limit 0.1 ppm (0.7 mg/m3), Skin, JAN1999
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Occupational Exposure Limit - FRANCE
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VLE 0.1 ppm (0.7 mg/m3), JAN1999
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Occupational Exposure Limit - GERMANY
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MAK 0.1 ppm (0.7 mg/m3), JAN1999
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Occupational Exposure Limit - THE NETHERLANDS
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MAC-TGG 0.7 mg/m3, 2003
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Occupational Exposure Limit - INDIA
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time-weighted average 0.1 ppm (0.7 mg/m3), short term exposure limit 0.3 ppm (2 mg/m3), JAN1993
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Occupational Exposure Limit - JAPAN
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Occupational Exposure Limit 0.1 ppm (0.65 mg/m3), JAN1999
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Occupational Exposure Limit - NORWAY
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time-weighted average 0.1 ppm (0.7 mg/m3), JAN1999
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Occupational Exposure Limit - THE PHILIPPINES
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time-weighted average 0.1 ppm (0.7 mg/m3), JAN1999
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Occupational Exposure Limit - POLAND
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MAC(time-weighted average) 0.7 mg/m3, MAC(short term exposure limit) 2 mg/m3, JAN1999
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Occupational Exposure Limit - RUSSIA
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time-weighted average 0.1 ppm, short term exposure limit 0.5 mg/m3, JAN1993
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Occupational Exposure Limit - SWEDEN
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NGV 0.1 ppm (0.7 mg/m3), KTV 0.3 ppm (2 mg/m3), JAN1999
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Occupational Exposure Limit - SWITZERLAND
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MAK- week 0.1 ppm (0.7 mg/m3), KZG- week 0.2 ppm, JAN1999
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Occupational Exposure Limit - TURKEY
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time-weighted average 0.1 ppm (0.7 mg/m3), JAN1993
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Occupational Exposure Limit - UNITED KINGDOM
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time-weighted average 0.1 ppm (0.66 mg/m3), short term exposure limit 0.3 ppm (2.0 mg/m3), SEP2000
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Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; | short term exposure limit 0.2 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value |
short term exposure limit 0.2 ppm | |||||||||||||||||||||||
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BROMINE-air
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10 hour time-weighted average 0.1 ppm; | short term exposure limit 0.3 ppm
NIOSH* DHHS #92-100,1992
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National Occupational Hazard Survey 1974
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National Occupational Hazard Survey 1974: Hazard Code: 13100; | Number of Industries 17; Total Number of Facilities 583; Number of Occupations 16; Total Number of Employees Exposed 23,977
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: 13100 |
 ;Number of Industries 40; Total Number of Facilities 1,679; Number of Occupations 55; Total Number of Employees Exposed 62,214; Total Number of Female Employees Exposed 10,780 | ||||
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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EPA TSCA Section 8(d) unpublished health/safety studies
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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NIOSH Analytical Method, 1994: Bromine and chlorine, 6011
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OSHA ANALYTICAL METHOD #ID-108
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REFERENCES:
CODEN
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REFERENCE
34ZIAG
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"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
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AIHAAP
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American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH
44311) V.19- 1958-
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CFRGBR
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Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents,
Washington, DC 20402)
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CLCHAU
|
Clinical Chemistry (Winston-Salem, NC). (American Assoc. for Clinical Chemistry, 1725 K St.,
NW, Washington, DC 20006) V.1- 1955-
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DTLVS*
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The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
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FEREAC
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Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
V.1- 1936-
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FOREAE
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Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ.
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GISAAA
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Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) V.1- 1936-
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GTPZAB
|
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see
MTPEEI
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HBTXAC
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"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
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KOTTAM
|
Kogai to Taisaku. Journal of Environmental Pollution Control. (Kogai Taisaku Gijutsu
Dokokai, Shuwa-Akasaka Bldg., 9-1-244, Akasaka, Minato-ku, Tokyo 107, Japan) V.1- 1965-
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NIOSH*
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National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and
Welfare, Reports and Memoranda.
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RBREV*
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Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report),
Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental
Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
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VCVN5*
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"Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous
substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al.,
Chimia, 1989.
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