The Registry of Toxic Effects of Chemical Substances

Bromic acid, sodium salt

RTECS #: EF8750000

CAS #: 7789-38-0

UPDATE: February 2004 MW: 150.90 MF: BrO3•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Bromate de sodium (French)
  2. Neutralizer K 126
  3. Neutralizer K 140
  1. Neutralizer K 938
  2. Sodium bromate (NaBrO3)
  3. Dyetone


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
specific locus test mouse other cell types 100 mg/L/4 hour MUREAV 537,21,2003


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 140 mg/kg N/R COREAF 257,791,1963
intravenous
rabbit 		lowest published lethal dose: 360 mg/kg Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea

Blood: Other changes 		SAPHAO 30,337,1913
oral
rabbit 		lowest published lethal dose: 250 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Blood: Other changes 		SAPHAO 30,337,1913
oral
woman 		lowest published toxic dose: 150 mg/kg Ear: Change in acuity

Behavioral: Somnolence (general depressed activity)

Kidney, Ureter, and Bladder: Urine volume decreased or anuria 		JFASEO 92(Suppl 4),S262,1993
subcutaneous
dog 		lowest published lethal dose: 120 mg/kg Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory depression

Blood: Other changes 		SAPHAO 30,337,1913
subcutaneous
guinea pig 		lowest published lethal dose: 100 mg/kg Lung, Thorax, or Respiration: Respiratory depression

Kidney, Ureter, and Bladder: Hematuria

Blood: Other changes 		SAPHAO 30,337,1913


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 4,480 mg/kg/28 day- continuous Endocrine: Changes in spleen weight

Blood: Changes in other cell count (unspecified) 		TOXID9 54,156,2000
oral
rat 		lowest published toxic dose: 896 mg/kg/35 day- continuous Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) NTIS** PB96-190640


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4132;
Number of Industries 5;
Total Number of Facilities 2,680;
Number of Occupations 9;
Total Number of Employees Exposed 27,921;
Total Number of Female Employees Exposed 18,633


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the oxidation of SULFUR and vat dyes
NTP Carcinogenesis studies; on test (prechronic studies), October 2000


REFERENCES:

CODEN
REFERENCE
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
JFASEO Journal of the Formosan Medical Association. (Excerpta Medica Asia Ltd., 3/F, 13 Duddell St. Central, Hong Kong, Hong Kong) V. 90- 1991-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SAPHAO Skandinavisches Archiv fuer Physiologie. (Stockholm, Sweden) V.1-83, 1899-1940. For publisher information, see APSCAX.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

Used in the oxidation of SULFUR and vat dyes

NIOSH PROFILE (HAIRDRESSING and BARBERS), SRC, 6/80

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

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