The Registry of Toxic Effects of Chemical Substances

Boric acid, trimethyl ester

RTECS #: ED5600000

CAS #: 121-43-7

UPDATE: November 2004 MW: 103.93 MF: C3H9BO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Borester O
  2. Methyl borate
  1. Trimethoxyborine
  2. Trimethylester kyseliny borite (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg moderate AJOPAA 29,1363,1946


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published lethal dose: 1 gm/kg N/R 14KTAK -,693,1964
intraperitoneal
rat 		lowest published lethal dose: 1,600 mg/kg N/R 14KTAK -,693,1964
intraperitoneal
rabbit 		lowest published lethal dose: 1,600 mg/kg N/R 14KTAK -,693,1964
oral
mouse 		lethal dose (50 percent kill): 1,290 mg/kg N/R 14KTAK -,693,1964
oral
rat 		lethal dose (50 percent kill): 6,140 mg/kg N/R 14KTAK -,693,1964
skin
rabbit 		lethal dose (50 percent kill): 1,980 µL/kg N/R AIHAAP 23,95,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 74430;
Number of Industries 3;
Total Number of Facilities 50;
Number of Occupations 4;
Total Number of Employees Exposed 1,090
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 74430;
Number of Industries 7;
Total Number of Facilities 192;
Number of Occupations 7;
Total Number of Employees Exposed 4,878;
Total Number of Female Employees Exposed 369


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in preparation of higher BORON esters, as a curing agent for EPOXY resins
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
14KTAK "Boron, Metallo-Boron Compounds and Boranes," Adams, R.M., ed., New York, John Wiley & Sons, Inc., 1964
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-

Used in preparation of higher BORON esters, as a curing agent for EPOXY resins

RTECS Compound Description:
   Primary Irritant

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