The Registry of Toxic Effects of Chemical Substances

Borane, trifluoro -

RTECS #: ED2275000

CAS #: 7637-07-2

UPDATE: November 2004 MW: 67.81 MF: BF3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Boron fluoride
  2. Boron trifluoride
  1. Boron trifluoride (ACGIH:OSHA)
  2. Fluorure de bore (French)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lethal concentration : >1,000 ppm/3 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Respiratory depression 		NTIS** OTS0546539
inhalation
guinea pig 		lethal concentration (50 percent kill): 109 mg/m3/4 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis

Blood: Hemorrhage 		FATOAO 35,369,1972
inhalation
guinea pig 		lowest published lethal concentration: 2,100 mg/m3/5 hour Eye: Lacrimation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea 		VCVN1* -,201,1988
inhalation
guinea pig 		lethal concentration (50 percent kill): 110 mg/m3 Eye: Lacrimation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea 		VCVN1* -,201,1988
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 8 mg/m3 Lung, Thorax, or Respiration: Cough VCVN1* -,201,1988
inhalation
mouse 		lethal concentration (50 percent kill): 3,460 mg/m3/2 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis

Blood: Hemorrhage 		FATOAO 35,369,1972
inhalation
mouse 		lowest published lethal concentration: 2,100 mg/m3/5 hour Eye: Lacrimation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea 		VCVN1* -,201,1988
inhalation
mouse 		lethal concentration (50 percent kill): 3,460 mg/m3 Eye: Lacrimation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea 		VCVN1* -,201,1988
inhalation
rat 		lethal concentration (50 percent kill): 1,180 mg/m3/4 hour N/R 85GMAT -,27,1982
inhalation
rat 		lowest published lethal concentration: 2,100 mg/m3/5 hour Eye: Lacrimation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea 		VCVN1* -,201,1988
inhalation
rat 		lethal concentration (50 percent kill): 1,180 mg/m3 Eye: Lacrimation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea 		VCVN1* -,201,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 12,800 ppb/7 hour/65 day- intermittent Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Nutritional and Gross Metabolic: Changes in: Other metals

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AIHAAP 22,263,1961
inhalation
guinea pig 		lowest published toxic concentration: 3 mg/m3/4 hour/17 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Blood: Changes in leukocyte (WBC) count 		FATOAO 35(3),369,1972
inhalation
guinea pig 		lowest published toxic concentration: 30 mg/m3/15 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVN1* -,201,1988
inhalation
guinea pig 		lowest published toxic concentration: 10 mg/m3/4 hour/16 week- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Liver function tests impaired

Blood: Changes in leukocyte (WBC) count 		VCVN1* -,202,1988
inhalation
guinea pig 		lowest published toxic concentration: 34 mg/m3/7 hour/61 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Liver function tests impaired

Blood: Changes in leukocyte (WBC) count 		VCVN1* -,202,1988
inhalation
mouse 		lowest published toxic concentration: 30 mg/m3/15 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVN1* -,201,1988
inhalation
rat 		lowest published toxic concentration: 12,800 ppb/7 hour/65 day- intermittent Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AIHAAP 22,263,1961
inhalation
rat 		lowest published toxic concentration: 10 mg/m3/4 hour/17 week- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Blood: Changes in leukocyte (WBC) count 		FATOAO 35(3),369,1972
inhalation
rat 		lowest published toxic concentration: 10 mg/m3/4 hour/16 week- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Liver function tests impaired

Blood: Changes in leukocyte (WBC) count 		VCVN1* -,202,1988
inhalation
rat 		lowest published toxic concentration: 34 mg/m3/7 hour/61 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Liver function tests impaired

Blood: Changes in leukocyte (WBC) count 		VCVN1* -,202,1988
inhalation
rabbit 		lowest published toxic concentration: 10 mg/m3/4 hour/16 week- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Liver function tests impaired

Blood: Changes in leukocyte (WBC) count 		VCVN1* -,202,1988
inhalation
rabbit 		lowest published toxic concentration: 34 mg/m3/7 hour/61 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Liver function tests impaired

Blood: Changes in leukocyte (WBC) count 		VCVN1* -,202,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value CL1 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD air-ceiling concentration 1 ppm (3 mg/m3) DTLVS* 3,26,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 1 ppm (3 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 1 ppm (3 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 1 ppm (3 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 1 ppm (3 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 1 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 1 ppm (3 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM short term exposure limit 1 ppm (2.8 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (3 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 1 ppm (3 mg/m3), short term exposure limit 3 ppm (8.3 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VLE 1 ppm (3 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 1 ppm (3 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC- continuous 3 mg/m3, 2003
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.3 ppm (0.83 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (3 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES short term exposure limit 1 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit - RUSSIA time-weighted average 0.3 ppm, short term exposure limit 1 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 1 ppm (3 mg/m3), KZG- week 2 ppm (6 mg/m3), JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 1 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 1 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 1 ppm (2.8 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

ceiling concentration1 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
ceiling concentration1 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BORON TRIFLUORIDE-air ceiling concentration 1 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 12980;
Number of Industries 10;
Total Number of Facilities 271;
Number of Occupations 13;
Total Number of Employees Exposed 4,021
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 12980;
Number of Industries 6;
Total Number of Facilities 79;
Number of Occupations 10;
Total Number of Employees Exposed 3,819;
Total Number of Female Employees Exposed 524


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

NIOSH PROFILE (BORON and ITS COMPOUNDS), SRC, 10/77

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