The Registry of Toxic Effects of Chemical Substances

2 - Biphenylol

RTECS #: DV5775000

CAS #: 90-43-7

UPDATE: May 2005 MW: 170.22 MF: C12H10O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. o - Biphenylol
  2. Invalon OP
  3. NCI - C50351
  4. Nectryl
  5. o - Phenylphenol
  6. 2 - Phenylphenol
  7. Torsite
  8. (1,1' - Biphenyl) - 2 - ol
  9. Biphenyl, 2 - hydroxy -
  10. o - Diphenylol
  11. Dowicide 1
  12. Dowicide 1 antimicrobial
  13. 2 - Fenylfenol (Czech)
  14. 2 - Hydroxybifenyl (Czech)
  1. o - Hydroxybiphenyl
  2. 2 - Hydroxybiphenyl
  3. o - Hydroxydiphenyl
  4. 2 - Hydroxydiphenyl
  5. Orthohydroxydiphenyl
  6. Orthophenylphenol
  7. Orthoxenol
  8. Phenol, o - phenyl -
  9. Preventol O Extra
  10. Remol TRF
  11. Tetrosin OE
  12. Tumescal OPE
  13. USAF EK - 2219
  14. o - Xenol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		50 µg/24 hour severe 85JCAE -,228,1986
skin
human 		0.5%/76 hour mild CRTXB2 32,551,2002
skin
rabbit 		250 mg mild MccSB# 15JUN1984
skin
rabbit 		20 mg/24 hour moderate 85JCAE -,228,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 100 mg/L MUREAV 141,95,1984
cytogenetic analysis human fibroblast 200 µg/L MUREAV 54,255,1978
DNA damage oral
mouse 		2 gm/kg MUREAV 395,189,1997
DNA repair Escherichia coli 1 mg/disc CMSHAF 10,223,1981
unscheduled DNA synthesis oral
rat 		336 gm/kg/4 week- continuous CALEDQ 48,19,1989
mutation in microorganisms mouse lymphocyte 5 mg/L (+enzymatic activation step) NTPTR* NTP-TR-301,1986
mutation in microorganisms Salmonella typhimurium 60 µg/plate (+enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
micronucleus test oral
rat 		2 pph/14 day MUTAEX 17,89,2002
mutation in mammalian somatic cells human embryo 20 mg/L MUREAV 156,123,1985
mutation in mammalian somatic cells human other cell types 15 mg/L TRENAF 35,399,1984
mutation in mammalian somatic cells mouse lymphocyte 50 mg/L NTPTR* NTP-TR-301,1986
sister chromatid exchange hamster ovary 29,900 µg/L NTPTR* NTP-TR-301,1986
sex chromosome loss and nondisjunction Aspergillus nidulans 52 µmol/L EVHPAZ 31,81,1979


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 13,050 mg/kg (7-15 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TRENAF 29,89,1978
oral
mouse 		lowest published toxic dose: 13,050 mg/kg (7-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TRENAF 29,89,1978
oral
rat 		lowest published toxic dose: 6 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		NNGADV 3,365,1978
oral
rat 		lowest published toxic dose: 52,168 mg/kg (13 week male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		TRENAF 32-2,33,1981
oral
rabbit 		lowest published toxic dose: 6,500 mg/kg (7-19 day pregnant) Reproductive: Other effects on female NTIS** OTS0544434


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 478 gm/kg/91 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		FCTOD7 22,865,1984
oral
rat 		toxic dose : 478 gm/kg/91 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		FCTOD7 22,865,1984
oral
rat 		toxic dose : 135 gm/kg/26 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		FCTOD7 25,359,1987


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >949 mg/m3/1 hour N/R CRTXB2 32,551,2002
inhalation
rat 		lethal concentration (50 percent kill): >36 mg/m3/4 hour N/R CRTXB2 32,551,2002
intraperitoneal
mouse 		lethal dose (50 percent kill): 50 mg/kg N/R NTIS** AD277-689
intraperitoneal
mouse 		lethal dose (50 percent kill): 50 mg/kg Liver: Other changes VCVGK* -,218,1994
oral
cat 		lethal dose (50 percent kill): 500 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Blood: Hemorrhage 		ANALAO 70,334,1945
oral
cat 		lethal dose (50 percent kill): 500 mg/kg N/R CRTXB2 32,551,2002
oral
dog 		lowest published toxic dose: 100 mg/kg Gastrointestinal: Nausea or vomiting CRTXB2 32,551,2002
oral
guinea pig 		lethal dose (50 percent kill): 3,500 mg/kg N/R CRTXB2 32,551,2002
oral
mouse 		lethal dose (50 percent kill): 1,050 mg/kg Behavioral: Ataxia

Cardiac: Other changes

Lung, Thorax, or Respiration: Respiratory depression 		NAIZAM 32,425,1981
oral
mouse 		lowest published lethal dose: 1,500 mg/kg Liver: Other changes VCVGK* -,218,1994
oral
mouse 		lethal dose (50 percent kill): 1,050 mg/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease 		CRTXB2 32,551,2002
oral
mouse 		lowest published toxic dose: 1,000 mg/kg Skin and Appendages: Other: Hair CRTXB2 32,551,2002
oral
rat 		lethal dose (50 percent kill): 2 gm/kg N/R NNGADV 3,365,1978
oral
rat 		lethal dose (50 percent kill): 2,700 mg/kg Liver: Other changes VCVGK* -,218,1994
oral
rat 		lowest published toxic dose: 2,500 mg/kg Liver: Hepatitis (hepatocellular necrosis), diffuse CRTXB2 32,551,2002
oral
rat 		lowest published toxic dose: 1,400 mg/kg Liver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		CRTXB2 32,551,2002
subcutaneous
rat 		lowest published toxic dose: 2,500 mg/kg Liver: Hepatitis (hepatocellular necrosis), diffuse CRTXB2 32,551,2002
skin
rat 		lethal dose (50 percent kill): >2,000 mg/kg N/R CRTXB2 32,551,2002
skin
rabbit 		lethal dose (50 percent kill): >5,000 mg/kg N/R CRTXB2 32,551,2002
unreported route
rat 		lethal dose (50 percent kill): 2,700 mg/kg N/R TRENAF 29,89,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 31 gm/kg/31 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JPETAB 104,202,1952
oral
mouse 		lowest published toxic dose: 61,250 µg/kg/7 week- continuous Immunological Including Allergic: Decrease in humoral immune response

Immunological Including Allergic: Decreased immune response 		DCTODJ 2,167,1979
oral
mouse 		lowest published toxic dose: 2 gm/kg/2 week- intermittent Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Blood: Changes in erythrocyte (RBC) count 		TXAPA9 58,252,1981
oral
mouse 		lowest published toxic dose: 1,752 mg/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain VCVGK* -,220,1994
oral
mouse 		lowest published toxic dose: 182.5 gm/kg/2 year- continuous Liver: Other changes

Liver: Changes in liver weight 		CRTXB2 32,551,2002
oral
mouse 		lowest published toxic dose: 365 gm/kg/2 year- continuous Liver: Tumors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		CRTXB2 32,551,2002
oral
mouse 		lowest published toxic dose: 182.5 gm/kg/2 year- continuous Liver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		CRTXB2 32,551,2002
oral
rat 		lowest published toxic dose: 876 gm/kg/2 year- continuous Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		YKYUA6 35,779,1984
oral
rat 		lowest published toxic dose: 728 gm/kg/2 year- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight 		JPETAB 104,202,1952
oral
rat 		lowest published toxic dose: 46,500 mg/kg/31 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JPETAB 104,202,1952
oral
rat 		lowest published toxic dose: 4,500 mg/kg/3 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) CRTXB2 32,551,2002
oral
rat 		lowest published toxic dose: 135 gm/kg/90 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain CRTXB2 32,551,2002
oral
rat 		lowest published toxic dose: 170.625 gm/kg/13 week- continuous Kidney, Ureter, and Bladder: Interstitial nephritis

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		CRTXB2 32,551,2002
oral
rat 		lowest published toxic dose: 110.25 gm/kg/21 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain CRTXB2 32,551,2002
oral
rat 		lowest published toxic dose: 477.75 gm/kg/91 week- continuous Kidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Bladder tumors

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		CRTXB2 32,551,2002
oral
rat 		lowest published toxic dose: 955.5 gm/kg/91 week- continuous Behavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Interstitial nephritis

Kidney, Ureter, and Bladder: Bladder tumors 		CRTXB2 32,551,2002
oral
rat 		lowest published toxic dose: 109.5 gm/kg/1 year- continuous Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		CRTXB2 32,551,2002
oral
rat 		lowest published toxic dose: 175.2 gm/kg/1 year- continuous Kidney, Ureter, and Bladder: Hematuria

Kidney, Ureter, and Bladder: Bladder tumors

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		CRTXB2 32,551,2002
oral
rat 		lowest published toxic dose: 547.5 gm/kg/2 year- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes 		CRTXB2 32,551,2002
skin
mouse 		lowest published toxic dose: 26,640 mg/kg/4 week- intermittent Skin: After systemic exposure: Dermatitis, other NTPTR* NTP-TR-301,1986
skin
rat 		lowest published toxic dose: 15 gm/kg/21 day- intermittent Skin: After topical application: Primary irritation CRTXB2 32,551,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 73,451,1999
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 30,329,1983
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 30,329,1983
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 73,451,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 73,451,1999
TOXICOLOGY REVIEW
CRTXB2 32,551,2002
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 567,347,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,200,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81040;
Number of Industries 67;
Total Number of Facilities 7,224;
Number of Occupations 58;
Total Number of Employees Exposed 221,003
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81040;
Number of Industries 135;
Total Number of Facilities 15,646;
Number of Occupations 114;
Total Number of Employees Exposed 617,394;
Total Number of Female Employees Exposed 379,044


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the manufacture of plastics, resins, rubber, as agricultural chemical, pesticide
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (derm);no evidence:rat


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ANALAO Analyst (London). (Royal Soc. of Chemistry, Distribution Centre, Blackhorse Rd., Letchworth Herts SG6 1HN, UK) V.1- 1877-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
MccSB# Personal Communication from S.B. McCollister, Dow Chemical USA, Midland, MI 48640, June 15, 1984
NAIZAM Nara Igaku Zasshi. Journal of the Nara Medical Association. (Nara Igakkai, c/o Narakenritsu Ika Daigaku, Shijo-cho, Kashihara, Nara-ken, Japan) V.1- 1950-
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1- 1949/50-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used in the manufacture of plastics, resins, rubber, as agricultural chemical, pesticide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

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