The Registry of Toxic Effects of Chemical Substances
Biphenyl, mixed with biphenyl oxide (3:7) |
UPDATE: November 2004 | MW: 324.44 | MF: C12H10O𥺂12H10 |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
eye rabbit | 500 mg/24 hour | mild | 28ZPAK -,271,1972 |
skin rabbit | 500 mg/24 hour | mild | 28ZPAK -,271,1972 |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
N/R | N/R | N/R | N/R |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation human | lowest published toxic concentration: 3 ppm |
Olfaction: Other olfaction effects Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Other changes | 28ZRAQ -,204,1960 |
inhalation human | lowest published toxic concentration: 26.8 mg/m3 |
Eye: Conjunctiva irritation Behavioral: Headache Lung, Thorax, or Respiration: Cough | VCVGK* -,308,1984 |
oral guinea pig | lethal dose (50 percent kill): 3 gm/kg | N/R | 85GMAT -,61,1982 |
oral mouse | lethal dose (50 percent kill): 3,200 mg/kg | N/R | VCVGK* -,308,1984 |
oral rat | lethal dose (50 percent kill): 2,460 mg/kg | N/R | 28ZPAK -,271,1972 |
oral rabbit | lethal dose (50 percent kill): 4,200 mg/kg | N/R | VCVGK* -,308,1984 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation rat | lowest published toxic concentration: 200 痢/m3/24 hour/70 day- continuous |
Behavioral: Muscle contraction or spasticity Kidney, Ureter, and Bladder: Other changes in urine composition Biochemical: Metabolism (intermediary): Porphyrin including bile pigments | GISAAA 26(5),3,1961 |
inhalation rat | lowest published toxic concentration: 20 mg/m3/4 hour/122 day- intermittent |
Lung, Thorax, or Respiration: Emphysema Blood: Change in clotting factors Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VCVGK* -,308,1994 |
inhalation rat | lowest published toxic concentration: 10 mg/m3/70 day- continuous |
Behavioral: Muscle weakness Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Metabolism (intermediary): Porphyrin including bile pigments | VCVGK* -,308,1994 |
oral rat | lowest published toxic dose: 130 mg/kg/26 week- intermittent |
Kidney, Ureter, and Bladder: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | ATORAI -,1,1948 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
TOXICOLOGY REVIEW |
| ATORAI -,-,1948 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Mine Safety and Health Administration (MSHA) STANDARD - air | time-weighted average 1 ppm (7 mg/m3) (vapor) | DTLVS* 3,206,1971 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8 hour time-weighted average 1 ppm (7 mg/m3), vapor | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8 hour time-weighted average 1 ppm (7 mg/m3), vapor | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8 hour time-weighted average 1 ppm (7 mg/m3), vapor | CFRGBR 29,1915.1000,1993 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8 hour time-weighted average 1 ppm (7 mg/m3), vapor | CFRGBR 41,50-204.50,1994 |
Occupational Exposure Limit - GERMANY | MAK 1 ppm (7 mg/m3), JAN1993 | |
Occupational Exposure Limit - THE PHILIPPINES | time-weighted average 1 ppm (7 mg/m3), JAN1993 | |
Occupational Exposure Limit - RUSSIA | short term exposure limit 10 mg/m3, JAN1993 | |
Occupational Exposure Limit - SWITZERLAND | MAK- week 1 ppm (7 mg/m3), JAN1999 | |
Occupational Exposure Limit - THE NETHERLANDS | MAC-TGG 7 mg/m3, 2003 |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHENYL ETHER-BIPHENYL MIXTURE, vapor-air | 10 hour time-weighted average 1 ppm | NIOSH* DHHS#92-100,1992 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA TSCA Section 8(d) unpublished health/safety studies | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NIOSH Analytical Method, 1994: Phenyl ether-diphenyl mixture, 2013 |
REFERENCES: | |
CODEN |
REFERENCE |
28ZPAK | "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 |
28ZRAQ | "Toxicology and Biochemistry of Aromatic Hydrocarbons," Gerarde, H., New York, Elsevier, 1960 |
85GMAT | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 |
ATORAI | A.P.I. Toxicological Review. (American Petroleum Institute, 2101 L St., NW, Washington, DC 20037) |
CFRGBR | Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) |
DTLVS* | The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 |
GISAAA | Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- |
NIOSH* | National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. |
VCVGK* | "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. |