The Registry of Toxic Effects of Chemical Substances

Biphenyl, mixed with biphenyl oxide (3:7)

RTECS #: DV1500000

CAS #: 8004-13-5

UPDATE: November 2004 MW: 324.44 MF: C12H10O•C12H10


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Biphenyl - diphenyl ether mixture
  2. 1,1' - Biphenyl, mixt. with 1,1' - oxybis (benzene)
  3. Dinil
  4. Dinyl
  5. Diphenyl mixed with diphenyl oxide
  1. Diphyl
  2. Dowtherm
  3. Dowtherm A
  4. Phenyl ether - biphenyl mixture (OSHA)
  5. Phenyl ether - diphenyl mixture


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg/24 hour mild 28ZPAK -,271,1972
skin
rabbit 		500 mg/24 hour mild 28ZPAK -,271,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 3 ppm Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes 		28ZRAQ -,204,1960
inhalation
human 		lowest published toxic concentration: 26.8 mg/m3 Eye: Conjunctiva irritation

Behavioral: Headache

Lung, Thorax, or Respiration: Cough 		VCVGK* -,308,1984
oral
guinea pig 		lethal dose (50 percent kill): 3 gm/kg N/R 85GMAT -,61,1982
oral
mouse 		lethal dose (50 percent kill): 3,200 mg/kg N/R VCVGK* -,308,1984
oral
rat 		lethal dose (50 percent kill): 2,460 mg/kg N/R 28ZPAK -,271,1972
oral
rabbit 		lethal dose (50 percent kill): 4,200 mg/kg N/R VCVGK* -,308,1984


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 200 µg/m3/24 hour/70 day- continuous Behavioral: Muscle contraction or spasticity

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments 		GISAAA 26(5),3,1961
inhalation
rat 		lowest published toxic concentration: 20 mg/m3/4 hour/122 day- intermittent Lung, Thorax, or Respiration: Emphysema

Blood: Change in clotting factors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGK* -,308,1994
inhalation
rat 		lowest published toxic concentration: 10 mg/m3/70 day- continuous Behavioral: Muscle weakness

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments 		VCVGK* -,308,1994
oral
rat 		lowest published toxic dose: 130 mg/kg/26 week- intermittent Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		ATORAI -,1,1948


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
ATORAI -,-,1948


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 ppm (7 mg/m3) (vapor) DTLVS* 3,206,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1 ppm (7 mg/m3), vapor CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1 ppm (7 mg/m3), vapor CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1 ppm (7 mg/m3), vapor CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1 ppm (7 mg/m3), vapor CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - GERMANY MAK 1 ppm (7 mg/m3), JAN1993
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1 ppm (7 mg/m3), JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 1 ppm (7 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 7 mg/m3, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHENYL ETHER-BIPHENYL MIXTURE, vapor-air 10 hour time-weighted average 1 ppm NIOSH* DHHS#92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Phenyl ether-diphenyl mixture, 2013


REFERENCES:

CODEN
REFERENCE
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
28ZRAQ "Toxicology and Biochemistry of Aromatic Hydrocarbons," Gerarde, H., New York, Elsevier, 1960
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
ATORAI A.P.I. Toxicological Review. (American Petroleum Institute, 2101 L St., NW, Washington, DC 20037)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Human Data
   Primary Irritant

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