RTECS:DS4025000 The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH

The Registry of Toxic Effects of Chemical Substances

Beryllium oxide

RTECS #: DS4025000

CAS #: 1304-56-9

UPDATE: May 2005 MW: 25.01 MF: BeO

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

REPRODUCTIVE EFFECTS DATA:

TUMORIGENIC DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Beryllia

Beryllium monoxide

Thermalox

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intratracheal
rat lowest published toxic dose: 139 mg/kg (3 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities GISAAA 51(8),44,1986

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published toxic concentration: 28 mg/m³/17 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors IMSUAI 40,23,1971
inhalation
rabbit lowest published toxic concentration: 17 mg/m³/5 hour/48 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Musculoskeletal: Tumors AMPLAO 51,473,1951
implant
rabbit lowest published toxic dose: 10 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Musculoskeletal: Tumors ARPAAQ 88,89,1969
intratracheal
rat lowest published toxic dose: 75 mg/kg/15 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors FKIZA4 71,19,1980
intratracheal
rat toxic dose : 169 mg/kg/2 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects AMIHAB 19,190,1959
intratracheal
rat toxic dose : 79 mg/kg/15 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors SAIGBL 20,230,1978
intravenous
rabbit lowest published toxic dose: 500 mg/kg/6 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Musculoskeletal: Tumors FEPRA7 5,221,1946
intravenous
rabbit toxic dose : 500 mg/kg/48 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Musculoskeletal: Tumors PEXTAR 2,203,1961
intravenous
rabbit toxic dose : 625 mg/kg/25 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Musculoskeletal: Tumors AMSHAR 25,99,1977

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
human lowest published toxic concentration: 0.67 mg/m³ Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Body temperature increase VCVN1* -,95,1988
inhalation
mammal (species unspecified) lowest published toxic concentration: 0.2 mg/m³/1 hour Lung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Autoimmune (multiple organ involvement) VCVN1* -,94,1988
intratracheal
rat lowest published toxic dose: 5 mg/kg Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Bronchogenic carcinoma

Nutritional and Gross Metabolic: Weight loss or decreased weight gain VCVN1* -,94,1988
oral
mouse lethal dose (50 percent kill): 2,062 mg/kg N/R VCVN1* -,93,1988

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published toxic concentration: 2 mg/m³/110 day- intermittent Lung, Thorax, or Respiration: Fibrosis (interstitial)

Liver: Hepatitis (hepatocellular necrosis), zonal

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN1* -,95,1988

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.002 mg(Be)/m³ DTLVS* TLV/BEI,1999
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Suspected human carcinogen DTLVS* TLV/BEI,1999
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 1,17,1972
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 23,143,1980
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 58,41,1993
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 58,41,1993
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMEMDT 58,41,1993
TOXICOLOGY REVIEW
CTOXAO 6,497,1973
TOXICOLOGY REVIEW
FCTXAV 9,105,1971

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.002 mg(Be)/m³ CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.002 mg(Be)/m³ CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.002 mg(Be)/m³ CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.002 mg(Be)/m³ CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.002 mg(Be)/m³, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.002 mg(Be)/m³, Carcinogen, JAN1993
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.002 mg(Be)/m³, Carcinogen, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.001 mg(Be)/m³, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.002 mg(Be)/m³, short term exposure limit 0.006 mg(Be)/m³, Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE VME 0.002 mg(Be)/m³, continuous2 Carcinogen, JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - HUNGARY short term exposure limit 0.001 mg(Be)/m³, Carcinogen, JAN1993
Occupational Exposure Limit - INDIA time-weighted average 0.002 mg(Be)/m³, Carcinogen, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.002 mg(Be)/m³, 2A Carcinogen, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.001 mg(Be)/m³, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.002 mg(Be)/m³, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.001 mg(Be)/m³, MAC(short term exposure limit) 0.003 mg(Be)/m³, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.001 mg(Be)/m³, Carcinogen, JAN1993
Occupational Exposure Limit - SWEDEN NGV 0.002 mg(Be)/m³, Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.002 mg(Be)/m³, Carcinogen, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.002 mg(Be)/m³, short term exposure limit 0.005 mg(Be)/m³, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.002 mg(Be)/m³, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.002 mg(Be)/m³, Carcinogen, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Suspected human carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Suspected human carcinogen

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BERYLLIUM-air Carcinogen not to exceed 0.0005 mg(Be)/m³ NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3577;
Number of Industries 6;
Total Number of Facilities 66;
Number of Occupations 9;
Total Number of Employees Exposed 4,305;
Total Number of Female Employees Exposed 849

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in manufacture of ceramics, in nuclear reactors and in production of beryllium alloys
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen

REFERENCES:
CODEN
REFERENCE

AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
AMPLAO AMA Archives of Pathology. (Chicago, IL) V.50(4)-69, 1950-60. For publisher information, see APLMAS.
AMSHAR Acta Morphologica Academiae Scientiarum Hungaricae. (Budapest, Hungary) V.1-30, 1951-82.
ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50; V.70-99, 1960-75. For publisher information, see APLMAS.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
FKIZA4 Fukuoka Igaku Zasshi. (c/o Kyushu Daigaku Igakubu, Tatekasu, Fukuoka-shi, Fukuoka, Japan) V.33- 1940-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1960-
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

Used in manufacture of ceramics, in nuclear reactors and in production of beryllium alloys

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

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