The Registry of Toxic Effects of Chemical Substances

Beryllium nitrate

RTECS #: DS3675000

CAS #: 13597-99-4

UPDATE: May 2005 MW: 133.03 MF: BeN2O6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Beryllium dinitrate
  1. Nitric acid, beryllium salt


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA repair Bacillus subtilis 750 µg/disc MUREAV 264,163,1991
sister chromatid exchange hamster lung 31 mg/L MUREAV 264,163,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intratesticular
rat 		lowest published toxic dose: 10,803 µg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		JRPFA4 7,21,1964
intravenous
rat 		lowest published toxic dose: 31 µg/kg (18 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Hepatobiliary system 		56ZJAL 3,129,1994


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rat 		lowest published toxic dose: 50 mg/kg Behavioral: Somnolence (general depressed activity) JJATDK 20,313,2000
intraperitoneal
guinea pig 		lowest published lethal dose: 100 mg/kg N/R EQSSDX 1,1,1975
intraperitoneal
mouse 		lethal dose (50 percent kill): 500 µg/kg N/R EQSSDX 1,1,1975
intravenous
mouse 		lethal dose (50 percent kill): 3,160 µg/kg N/R CUSCAM 55,899,1986
subcutaneous
frog 		lowest published lethal dose: 1,041 mg/kg N/R RDWU** -,-,1930
subcutaneous
mouse 		lowest published lethal dose: 50 mg/kg N/R RDWU** -,-,1930


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rat 		lowest published toxic dose: 1,500 mg/kg/30 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Metabolism (intermediary): Other carbohydrates 		JEBIDP 12,63,1991


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.002 mg(Be)/m3 DTLVS* TLV/BEI,1999
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Suspected human carcinogen DTLVS* TLV/BEI,1999
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 58,41,1993
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 58,41,1993
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMEMDT 58,41,1993


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.002 mg(Be)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.002 mg(Be)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.002 mg(Be)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.002 mg(Be)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.002 mg(Be)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.002 mg(Be)/m3, Carcinogen, JAN1993
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.002 mg(Be)/m3, Carcinogen, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.001 mg(Be)/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.002 mg(Be)/m3, short term exposure limit 0.006 mg(Be)/m3, Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE VME 0.002 mg(Be)/m3, continuous2 Carcinogen, JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - HUNGARY short term exposure limit 0.001 mg(Be)/m3, Carcinogen, JAN1993
Occupational Exposure Limit - INDIA time-weighted average 0.002 mg(Be)/m3, Carcinogen, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.002 mg(Be)/m3, 2A Carcinogen, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.001 mg(Be)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.002 mg(Be)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.001 mg(Be)/m3, MAC(short term exposure limit) 0.003 mg(Be)/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.001 mg(Be)/m3, Carcinogen, JAN1993
Occupational Exposure Limit - SWEDEN NGV 0.002 mg(Be)/m3, Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.002 mg(Be)/m3, Carcinogen, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 0.002 mg(Be)/m3, short term exposure limit 0.005 mg(Be)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.002 mg(Be)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.002 mg(Be)/m3, Carcinogen, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Suspected human carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Suspected human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BERYLLIUM-air Carcinogen not to exceed 0.0005 mg(Be)/m3 NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen


REFERENCES:

CODEN
REFERENCE
56ZJAL "Metal Ions in Biology and Medicine, Proceedings of the International Symposium, 1st, 1990," Collery, P., and Manfait, M., et al., eds., Paris, France, 1990.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CUSCAM Current Science. (Current Science Assoc., Sadashivanagar P.O., Bangalore 560 080, India) V.1- 1932-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JEBIDP Journal of Environmental Biology. (Academy of Environmental Biology, India, 657/5, Civil Lines (South), Muzaffarnagar, 251001, India) V.1- 1980-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RDWU** "Beitrage zur Pharmakologie des Berylliums, Dissertation," Richter, U., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1930

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

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